Vocab for drugs Flashcards Preview

Neuro IV pharm > Vocab for drugs > Flashcards

Flashcards in Vocab for drugs Deck (13)
Loading flashcards...
1

Metabolic Tolerance

More drug needed to get same level in plasma.

Mechanism: Metabolism

2

Dependence

A state of neuroadaptation produced by repeated drug administration that necessitates continued drug administration to prevent the withdrawal syndrome from occurring.

3

Tolerance

A reduced effect of the drug generated by repeated administration of the drug in a particular environment.

4

Withdrawal

The exaggerated expression of drug effects experienced immediately after cessation of treatment.

5

Cross dependence

The ability of one drug to suppress the manifestations of another drug’s actions.

6

Pharmacodynamic Tolerance

Lessened response at target to same drug concentration (adaptive changes)

7

Learned tolerance

reduction in the effects of a drug cut to learned compensatory mechanism

behavioral tolerance
conditioned tolerance (environmental cues)

8

Reverse tolerance

Sensitization to drug following repeated doses

in nucleus accumbens may lead to cravings

9

Cross Tolerance

tolerance to one drug leads to tolerance to another drug of the same class or that acts through a similar mechanism.

10

Physical dependence

repeated use of drug that changes physiological state so need repeated administration to avoid withdrawal.

resetting homeostatic mechanism

11

Cross dependence

the ability of a drug to suppress the withdrawal associated with physical dependence on another drug.

related to pharmacological effects not chemical similarity

Ex: BDZs often used to suppress alcohol withdrawal

12

Psychological dependence

hard wire changes that lead to cravings.

13

Addiction

Extreme example of compulsive drug use. Individual becomes overwhelmingly concerned with the use of a drug and getting more. Tendency to relapse after withdrawal