Vocab for drugs Flashcards
Metabolic Tolerance
More drug needed to get same level in plasma.
Mechanism: Metabolism
Dependence
A state of neuroadaptation produced by repeated drug administration that necessitates continued drug administration to prevent the withdrawal syndrome from occurring.
Tolerance
A reduced effect of the drug generated by repeated administration of the drug in a particular environment.
Withdrawal
The exaggerated expression of drug effects experienced immediately after cessation of treatment.
Cross dependence
The ability of one drug to suppress the manifestations of another drug’s actions.
Pharmacodynamic Tolerance
Lessened response at target to same drug concentration (adaptive changes)
Learned tolerance
reduction in the effects of a drug cut to learned compensatory mechanism
behavioral tolerance conditioned tolerance (environmental cues)
Reverse tolerance
Sensitization to drug following repeated doses
in nucleus accumbens may lead to cravings
Cross Tolerance
tolerance to one drug leads to tolerance to another drug of the same class or that acts through a similar mechanism.
Physical dependence
repeated use of drug that changes physiological state so need repeated administration to avoid withdrawal.
resetting homeostatic mechanism
Cross dependence
the ability of a drug to suppress the withdrawal associated with physical dependence on another drug.
related to pharmacological effects not chemical similarity
Ex: BDZs often used to suppress alcohol withdrawal
Psychological dependence
hard wire changes that lead to cravings.
Addiction
Extreme example of compulsive drug use. Individual becomes overwhelmingly concerned with the use of a drug and getting more. Tendency to relapse after withdrawal
