Vocab for drugs Flashcards Preview

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Flashcards in Vocab for drugs Deck (13)
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1
Q

Metabolic Tolerance

A

More drug needed to get same level in plasma.

Mechanism: Metabolism

2
Q

Dependence

A

A state of neuroadaptation produced by repeated drug administration that necessitates continued drug administration to prevent the withdrawal syndrome from occurring.

3
Q

Tolerance

A

A reduced effect of the drug generated by repeated administration of the drug in a particular environment.

4
Q

Withdrawal

A

The exaggerated expression of drug effects experienced immediately after cessation of treatment.

5
Q

Cross dependence

A

The ability of one drug to suppress the manifestations of another drug’s actions.

6
Q

Pharmacodynamic Tolerance

A

Lessened response at target to same drug concentration (adaptive changes)

7
Q

Learned tolerance

A

reduction in the effects of a drug cut to learned compensatory mechanism

behavioral tolerance 
conditioned tolerance (environmental cues)
8
Q

Reverse tolerance

A

Sensitization to drug following repeated doses

in nucleus accumbens may lead to cravings

9
Q

Cross Tolerance

A

tolerance to one drug leads to tolerance to another drug of the same class or that acts through a similar mechanism.

10
Q

Physical dependence

A

repeated use of drug that changes physiological state so need repeated administration to avoid withdrawal.

resetting homeostatic mechanism

11
Q

Cross dependence

A

the ability of a drug to suppress the withdrawal associated with physical dependence on another drug.

related to pharmacological effects not chemical similarity

Ex: BDZs often used to suppress alcohol withdrawal

12
Q

Psychological dependence

A

hard wire changes that lead to cravings.

13
Q

Addiction

A

Extreme example of compulsive drug use. Individual becomes overwhelmingly concerned with the use of a drug and getting more. Tendency to relapse after withdrawal