Volume 4, Module 1 Flashcards

(4 cards)

1
Q

how does AKA (alcoholic ketoacidosis) occur?

A

multifactorial;

  1. malnourished = low glycogen stores
  2. increased lipolysis = poor nutritional intake, low insulin levels, increased sympathetic nervous system activity from decreasing alcohol levels
  3. inhibited hepatic gluconeogenesis
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2
Q
  • metabolism of ethanol by acetaldehyde dehydrogenase (ADH) = decrease in oxidized nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide hydride (NADH)
  • increased NADH/NAD+ ratio = inhibited hepatic gluconeogenesis and production of β-hydroxybutyrate from acetoacetate
  • also lactate forms from pyruvate
A

AKA metabolism

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3
Q

constellation of features c/w propofol infusion syndrome (PRIS)

A
  • metabolic acidosis
  • hypotension
  • bradycardia
  • fever
  • AKI
  • rhabdomyolysis
  • RBBB
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4
Q

other findings that can occur w/ PRIS

A
  • acute fatty liver
  • hypertriglyceridemia
  • precordial ST segment elevations
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