Volume 4, Module 1 Flashcards
(4 cards)
1
Q
how does AKA (alcoholic ketoacidosis) occur?
A
multifactorial;
- malnourished = low glycogen stores
- increased lipolysis = poor nutritional intake, low insulin levels, increased sympathetic nervous system activity from decreasing alcohol levels
- inhibited hepatic gluconeogenesis
2
Q
- metabolism of ethanol by acetaldehyde dehydrogenase (ADH) = decrease in oxidized nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide hydride (NADH)
- increased NADH/NAD+ ratio = inhibited hepatic gluconeogenesis and production of β-hydroxybutyrate from acetoacetate
- also lactate forms from pyruvate
A
AKA metabolism
3
Q
constellation of features c/w propofol infusion syndrome (PRIS)
A
- metabolic acidosis
- hypotension
- bradycardia
- fever
- AKI
- rhabdomyolysis
- RBBB
4
Q
other findings that can occur w/ PRIS
A
- acute fatty liver
- hypertriglyceridemia
- precordial ST segment elevations