VTE Flashcards

(50 cards)

1
Q

What happens in the body in VTE (DVT & PE)

A

DVT - a blood clot forms in the deep veins

PE - ^ that blood clot breaks off and travels to the right side of the heart and the right ventricles pumps it into the pulmonary artery

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2
Q

Risk factors

A

Long haul flights
Cancer
Hormone treatment
60+
hx of DVT
Varicose veins
Smoking
Obesity
HF

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3
Q

DVT features

A

Throbbing in 1 leg - thigh or claf

Red, warm skin

Swelling

Pitting odema

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4
Q

PE features

A

Pluretic chest pain

Cynosis

Difficulty breathing

Tachycardia

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5
Q

VTE provoking factors

(Not all VTEs are provoked only 50%)

A

Pregnancy
HRT/pill
Immobility
Surgery/trauma

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6
Q

What wells score indicates DVT

A

2 and over

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7
Q

What test do you do if DVT is likely

A

Offer leg ultrasound within 4 hours

If not possible then do a d dimer test and anticoagulate & arrange a scan within 24 hours

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8
Q

What we’ll score indicates that DVT is not likely

And what’s test would you do

A

Do d dimer test
• positive then arrange ultrasound
• negative- do not anticoagulate

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9
Q

What we’ll score indicates that PE is likely

A

Over 4

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10
Q

What test to offer is PE is likely

A

CT pulmonary angiography - CTPA

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11
Q

What we’ll score indicates that PE is not likely?

A

4 and under

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12
Q

What test do you do if PE is not likely

A

Do a d dimer test
• positive then arrange a CTPA

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13
Q

How long should anticoagulation be given for?

A

3 months

3-6 months in cancer

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14
Q

Management for those with no renal impairment, cancer or antiphospholipid syndrome

A

1st - Apixaban or Rivaroxaban

If Ci

LMWH (enoxaparin) for 5 days, the edoxaban or dabigatran

Or

LMWH + warfarin for 5 days (or INR is 2.0 on two different occasions

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15
Q

Management for those with renal impairment of 15-50

A

Apixaban Or Rivaroxaban

Or

LMWH for 5 days, the edoxaban or dabigatran (if crcl 30+)

Or

LMWH or UFH + warfarin for 5 days, then continue warfarin

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16
Q

Management for those with renal impairment of under 15

A

• UFH
or
• LMWH
Or
• LMWH or UFH + warfarin for 5 days, then continue warfarin

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17
Q

Management for those with renal impairment of those with active cancer

A

If DOACs not suitable then:

• LMWH
• LMWH + warfarin for 5 days then continue warfarin alone

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18
Q

Management for those with antiphospholipid syndrome

A

LMWH + warfarin for 5 days then continue warfarin alone

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19
Q

In surgical patients how long is pharmacological prophylaxis sufficient

A

7 days or until mobilized

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20
Q

Pharmacological prophylaxis for those undergoing elective HIP treatment

(Post)

A

LMWH for 10 days, then low dose aspirin for 28 days

OR

LMWH for 28 days + anti embolism stocking or riveroxaban

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21
Q

Pharmacological prophylaxis for those undergoing elective KNEE treatment

(Post)

A

Low dose Aspirin for 14 days

OR

LMWH for 14 days + anti-embolism stocking or Rivaroxaban

22
Q

Which drug is used for pharmacological prophylaxis for pregnant women are at risk of VTE and are not in active labour, or wbu have given birth, had a misscarge termination with the past 6 weeks

23
Q

When should LMWH be started for those women

A

4-8 hours after the event

24
Q

How long should the LMWH be continued for after initiation

25
1st line mechanical prophylaxis for pregnant women who are likely to be imobalised during their hospital stay
Intermittent pneumatic compression
26
Is Intermittent pneumatic compression is not suitable what is the alternative
Anti embolism stockings
27
When may mechanical prophylaxis NOT be suitable
Stroke PAD Odema Dermatitis
28
Stoping anticoagulation before 3 months increases risk of VTE True or false
True
29
Why are heparins used in pregnancy
They do not pass placenta They are also cleared rapidly
30
What is the non pharmacological way of treating VTE
Elasticated graduated compression stockings
31
What test can be used to suggest wether long term anticoagulation is appropriate
HAS-BLED Assess risk of bleeding
32
How often should patients on long term anticoagulation for VTE be reviewed
Annually
33
If LMWH is CI for the pregnant lady what can be given
IV heparin (unfractionated)
34
If a henoarrage occurs whilst on any heparin what should you do
STOP treatment Is rapid reversal is required - protamine sulfate (antidote)
35
Which DOACs are direct inhibitors of activated factor X (factor xa)
Apixaban Rivaroxaban Edoxaban
36
Which DOAC is a direct inhibitors of thrombin (factor IIA)
Dabigatran
37
Which DOAC should be taken with food
Rivaroxaban
38
Common ADRs of DOACs
Bleeding, anemia and skin reactions Additional for Rivaroxaban • constpation, GI discomfort
39
Can DOACs be crushed up
Yes NOT dabigatran
40
If patients are due to have surgery when should DOACs be stopped
24-72 hours
41
DOAC interactions
NSAIDs, Heparin, CYP inhibitors or inducers
42
Signs of anemia
Weak Tired Breathlessness
43
Examples of LMWH
Enoxaparin sodium Dalteparin
44
MOA
Binds to antithrombin (ATII) specifically to factor Xa then IIA
45
ADRs
Haemorrhage Skin reaction Hyperkalemia (it blocks Aldesteron)
46
If skin reaction occurs what to do?
STOP the anticoagulant
47
Drug interactions
Aspirin Warfarin DOACs NSAIDs ^drugs which increase bleeding risk Drugs which cause hyperkalemia
48
Which heparin is preferred in renal impairment
Unfractionated heparin
49
What is the timing for first dose of prophylaxis - within how many hours should it be provided
14
50
And a minim of how long should it be continued for (no surgeries like hip replacement ect)
7 days or when discharged