Vulval Itching/Lesion Flashcards

1
Q

What is the vulva

A

area of skin that stretches from the labia majora laterally to the mons pubis anteriorly and the perineum posteriorly, overlapping with the vestibule (area between labia minora and the hymen)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the causes of vulval itching

A

Infection: candidiasis, condylomata acuminata (HSV warts), pubic lice, scabies
Derm: eczema, psoriasis, lichen simplex, lichen sclerosus, lichen planus, dermatitis
Neoplasia: carcinoma, VIN
Other: Bartholin’s cyst, vaginal cyst, vaginal adenosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the symptoms of condylomata acuminata

A

Asymptomatic
or
Painful ulcers on the external genitalia ± cervix & rectum
Dysuria
Vaginal discharge
Fever/myalgia (rare)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the management for condylomata acuminata

A

Saline baths
Analgesia, topical anaesthetics
Antiviral drugs (oral better than topical) e.g. Acyclovir, valaciclovir, famciclovir
Catheterisation for acute urinary retention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is lichen simplex

A

Chronic inflammatory skin condition
AKA chronic vulval dermatitis
Sensitive skin, dermatitis or eczema result in lichen simplex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the symptoms and signs of lichen simplex

A

Severe intractable pruritus, especially at night
- May be exacerbated by chemical or contact dermatitis
- May be linked to stress or low iron
Area (typically labia majora) is inflamed and thickened with hyper and hypopigmentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What investigations should be done for lichen simplex

A

Clinical diagnosis

If in doubt - vulval biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the management for lichen simplex

A

Aim is to break the itch-scratch cycle
Avoid irritants e.g. soap
Emollients
Steroid creams
Antihistamines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is lichen sclerosus

A

Vulval epithelium is thin with the loss of collagen
May have an autoimmune basis

(associated with vulval carcinoma - 5%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the symptoms and signs of lichen sclerosus

A

Severe pruritus, Worse at night
Trauma with bleeding and skin splitting
Discomfort, pain, dyspareunia
Pink-white papules → coalesce to form parchment-like skin with fissures
Inflammatory adhesions → labial fusion → narrows the introitus

Hx thyroid issues or vitiligo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What investigations should be done for lichen sclerosus

A

Biopsy - exclude carcinoma and confirm diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the management for lichen sclerosus

A

Ultra-potent topical steroids (e.g. clobetasol proprionate (dermovate))

Second line: tacrolimus (topical calcineurin inhibitor) + biopsy (as steroid-resistant)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is lichen planus

A

Affects mucosal surfaces and the genital region

Unknown aetiology

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the signs and symptoms of lichen planus

A

Flat, papular, purplish lesions
- Mouth and genital regions
- Erosive
- Painful (rather than itchy)
- May see fine white lines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the management for lichen planus

A

1st line: High-dose topical steroids (e.g. Clobetasol)
2nd line: topical calcineurin inhibitor (e.g. tacrolimus)

If vaginal stenosis, dilatation with manual measures should be attempted in the first instance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Define VIN

A

Vaginal intraepithelial neoplasia (VIN) = presence of atypical cells in the vulval epithelium

17
Q

What are the types of VIN

A

Usual type
- Warty, basaloid, mixed
- Common in women aged 35-55
- RF: HPV (esp. HPV-16) | cervical intraepithelial neoplasia CIN | smoking | chronic immunosuppression
- Multifocal: Appearance varies widely: red, white, pigmented, plaques, papules, patches, erosions, nodules, warty, hyperkeratosis

Differentiated type
- Associated with lichen sclerosis
- Seen in older women
- Unifocal: ulcer or plaque
- Associated with keratinising squamous cell carcinomas of the vulva
- Risk of progression to cancer is higher than usual type VIN

18
Q

What is the management for VIN

A

Local surgical excision to relieve symptoms
Supportive: emollients, mild topical steroid

19
Q

What are the most common carcinomas of the vulva and what are the risk factors

A

95% of vulval malignancies are squamous cell carcinomas, the rest are melanomas, basal cells carcinomas, adenocarcinomas, and a variety of others

RF: lichen sclerosis | immunosuppression | smoking | Paget’s disease of the vulva

20
Q

What are the signs and symptoms of vulval carcinoma

A

Presentation: pruritus, bleeding, discharge, mass found
Examination: ulcer or mass (most commonly labia majora, clitoris) | tender and/or hard inguinal lymphadenopathy

21
Q

What investigations should be done for vulval carcinoma

A
  • Biopsy of lesion
  • Fitness for surgery: CXR, ECG, FBC, U&Es, cross match
22
Q

What is the staging for vulval carcinoma

A

1a: confined to vulva/perineum <2cm, stromal invasion <1mm
1b: confined to vulva/perineum >2cm, stromal invasion >1mm
2: adjacent spread (urethra, vagina, anus)
3. Positive inguinofemoral nodes
4: invades upper urethra/vagina, rectum, mets

23
Q

What is the management for vulval carcinoma

A

1a: local excision ± plastic surgeon
1b/2/3/4:
- sentinel lymph node biopsy
- Wide local excision and groin lymphadenectomy (triple incision radical vulvectomy)
± Plastic surgeon input

24
Q

Describe vaginal malignancies

A

Primary
- Older women
- Squamous origin
- Presentation: bleeding or discharge and a mass or ulcer evident
- Management: intravaginal radiotherapy, radical surgery
- 5-year survival 50%
- Vaginal adenosis (in-utero DES exposure) → clear cell adenocarcinoma
Secondary: from cervix, endometrium, vulva etc.

25
Describe Vulvar dysaesthesia (vulvodynia) (S&S, RF)
Vulval pain syndrome Diagnosis of exclusion Provoked or Spontaneous Local (vestibular) or generalised - Generalised: burning pain, older patients - Localised: superficial dyspareunia or pain on tampons, younger patients RF: Hx genital tract infections, former oral contraceptive use, psychosexual disorders
26
What is the management for vulvar dysaesthesia
amitriptyline OR gabapentin
27
Define female genital mutilation
all procedures that involve partial or total removal of the external female genitalia, or injury to the female genital organs for non medical reasons. It is a violation of the rights of the child and woman. It is child abuse and illegal in the UK
28
What are the types of FGM
Type 1: Clitoridectomy: partial/total removal of the clitoris and sometimes the prepuce (clitoral hood) Type 2: Partial/total removal of the clitoral glans and the labia minora, with or without removal of the labia majora Type 3: . Pharaonic: the labia majora are removed and the skin is stitched together (vaginal opening no longer exposed) Type 4: All other harmful procedures to the female genitalia for non-medical purposes e.g. pricking, piercing, incising, cauterizing, nicking
29
What is the epidemiology of FGM
200 million girls and women worldwide living with the consequences of FGM, 5% global female population. Occurs mainly in North/central-Africa (Somalia, Egypt, Sudan, Ethiopia), Malaysia, Indonesia, India, Yemen, Syria but occurs globally, practiced in over 28 African countries Age of FGM varies from a few days old to adulthood depending on the geographical area and community, but usually averages 5-14 years old. 18% of all FGM is performed by healthcare providers.
30
What are the procedural options for FGM
Deinfibulation The opening procedure for women with type 3 FGM. It can help alleviate some physical symptoms but cannot replace the tissue that has been removed. It can be done under local, spinal or general anaesthetic The incision should be made along the vulval incision scar and the urethra identified before surgery commences to reduce damage Screen for UTI and consider Abx prophylaxis Offered to those unable to have sex comfortably, pass urine, or pregnant women at risk during delivery Clitoral/labial reconstruction Not currently available in the UK.
31
What is Reinfubulation
Re-closure of a woman with Type 3 FGM, usually after childbirth. It is illegal in the UK. This can happen multiple times with the birth of each child.
32
What are the short term complications of FGM
Haemorrhage Severe pain and shock Urine retention Injury to adjacent tissue Tetanus, HIV, hep B/C Fracture or dislocation of limbs as a result of being restrained Death through severe bleeding → haemorrhagic shock, neurogenic shock, infection, septicaemia
33
What are the long term complications of FGM
Dysuria/recurrent UTIs Renal failure Recurrent candida infections Abscesses due to infected cysts/horns Dysmenorrhoea Dyspareunia Sexual dysfunction and lack of sexual pleasure Infertility Acute/chronic pelvic infections Clitoral neuroma
34
What obstetric issues may arise with FGM
May not be identified antenatally Difficulty with Vaginal examinations Scarring and stricture of the vaginal canal Possible obstructed labour Psychological trauma Flashbacks Increased risk of caesarean sections, PPH< foetal asphyxia/anoxia Perineal trauma/tears -> scar tissue, fistulae
35
What is the management for FGM
1. Safeguarding and reporting 2. Document FGM in notes (name, DoB, address, type, in red book if young) 2. Women should be identified and referred to specialist gynaecology/ FGM clinic 3. Counsel on FGM and its risks 4. Offer and recommend deinfibulation 5. Mental health support
36
What are the reporting guidelines for FGM
<18: report to the police (serious crimes 2015) via 101 non-emergency within 1 month + inform the FGM specialist midwife or the safeguarding team + social care referral >18: safeguarding and assess risk to female children or younger siblings, reporting not required, must document in notes If a mother discloses that her daughters or siblings have had FGM, the MR duty does NOT apply - but you must do a normal safeguarding referral to children's social care.