Vulval Itching/Lesion Flashcards
What is the vulva
area of skin that stretches from the labia majora laterally to the mons pubis anteriorly and the perineum posteriorly, overlapping with the vestibule (area between labia minora and the hymen)
What are the causes of vulval itching
Infection: candidiasis, condylomata acuminata (HSV warts), pubic lice, scabies
Derm: eczema, psoriasis, lichen simplex, lichen sclerosus, lichen planus, dermatitis
Neoplasia: carcinoma, VIN
Other: Bartholin’s cyst, vaginal cyst, vaginal adenosis
What are the symptoms of condylomata acuminata
Asymptomatic
or
Painful ulcers on the external genitalia ± cervix & rectum
Dysuria
Vaginal discharge
Fever/myalgia (rare)
What is the management for condylomata acuminata
Saline baths
Analgesia, topical anaesthetics
Antiviral drugs (oral better than topical) e.g. Acyclovir, valaciclovir, famciclovir
Catheterisation for acute urinary retention
What is lichen simplex
Chronic inflammatory skin condition
AKA chronic vulval dermatitis
Sensitive skin, dermatitis or eczema result in lichen simplex
What are the symptoms and signs of lichen simplex
Severe intractable pruritus, especially at night
- May be exacerbated by chemical or contact dermatitis
- May be linked to stress or low iron
Area (typically labia majora) is inflamed and thickened with hyper and hypopigmentation
What investigations should be done for lichen simplex
Clinical diagnosis
If in doubt - vulval biopsy
What is the management for lichen simplex
Aim is to break the itch-scratch cycle
Avoid irritants e.g. soap
Emollients
Steroid creams
Antihistamines
What is lichen sclerosus
Vulval epithelium is thin with the loss of collagen
May have an autoimmune basis
(associated with vulval carcinoma - 5%)
What are the symptoms and signs of lichen sclerosus
Severe pruritus, Worse at night
Trauma with bleeding and skin splitting
Discomfort, pain, dyspareunia
Pink-white papules → coalesce to form parchment-like skin with fissures
Inflammatory adhesions → labial fusion → narrows the introitus
Hx thyroid issues or vitiligo
What investigations should be done for lichen sclerosus
Biopsy - exclude carcinoma and confirm diagnosis
What is the management for lichen sclerosus
Ultra-potent topical steroids (e.g. clobetasol proprionate (dermovate))
Second line: tacrolimus (topical calcineurin inhibitor) + biopsy (as steroid-resistant)
What is lichen planus
Affects mucosal surfaces and the genital region
Unknown aetiology
What are the signs and symptoms of lichen planus
Flat, papular, purplish lesions
- Mouth and genital regions
- Erosive
- Painful (rather than itchy)
- May see fine white lines
What is the management for lichen planus
1st line: High-dose topical steroids (e.g. Clobetasol)
2nd line: topical calcineurin inhibitor (e.g. tacrolimus)
If vaginal stenosis, dilatation with manual measures should be attempted in the first instance
Define VIN
Vaginal intraepithelial neoplasia (VIN) = presence of atypical cells in the vulval epithelium
What are the types of VIN
Usual type
- Warty, basaloid, mixed
- Common in women aged 35-55
- RF: HPV (esp. HPV-16) | cervical intraepithelial neoplasia CIN | smoking | chronic immunosuppression
- Multifocal: Appearance varies widely: red, white, pigmented, plaques, papules, patches, erosions, nodules, warty, hyperkeratosis
Differentiated type
- Associated with lichen sclerosis
- Seen in older women
- Unifocal: ulcer or plaque
- Associated with keratinising squamous cell carcinomas of the vulva
- Risk of progression to cancer is higher than usual type VIN
What is the management for VIN
Local surgical excision to relieve symptoms
Supportive: emollients, mild topical steroid
What are the most common carcinomas of the vulva and what are the risk factors
95% of vulval malignancies are squamous cell carcinomas, the rest are melanomas, basal cells carcinomas, adenocarcinomas, and a variety of others
RF: lichen sclerosis | immunosuppression | smoking | Paget’s disease of the vulva
What are the signs and symptoms of vulval carcinoma
Presentation: pruritus, bleeding, discharge, mass found
Examination: ulcer or mass (most commonly labia majora, clitoris) | tender and/or hard inguinal lymphadenopathy
What investigations should be done for vulval carcinoma
- Biopsy of lesion
- Fitness for surgery: CXR, ECG, FBC, U&Es, cross match
What is the staging for vulval carcinoma
1a: confined to vulva/perineum <2cm, stromal invasion <1mm
1b: confined to vulva/perineum >2cm, stromal invasion >1mm
2: adjacent spread (urethra, vagina, anus)
3. Positive inguinofemoral nodes
4: invades upper urethra/vagina, rectum, mets
What is the management for vulval carcinoma
1a: local excision ± plastic surgeon
1b/2/3/4:
- sentinel lymph node biopsy
- Wide local excision and groin lymphadenectomy (triple incision radical vulvectomy)
± Plastic surgeon input
Describe vaginal malignancies
Primary
- Older women
- Squamous origin
- Presentation: bleeding or discharge and a mass or ulcer evident
- Management: intravaginal radiotherapy, radical surgery
- 5-year survival 50%
- Vaginal adenosis (in-utero DES exposure) → clear cell adenocarcinoma
Secondary: from cervix, endometrium, vulva etc.