W06_01 Virology II

Question 1

what are 4 outcomes of a virus-host cell interaction?

Answer 1

cell death;
cell malignancy;
latent infection;
cell fusion;

Question 2

what are the 3 categories of persistent viral infections? (chronicity)

Answer 2

persistent;
latent;
slow-progressing (e.g. measles)

Question 3

what are the two best disinfectants when it comes to viruses?

Answer 3

hypochlorite (bleach) and gluteraldehyde

Question 4

resp and GI viruses incubate for how long?

Answer 4

0-2 days

Question 5

MMR, VZV, HSV, enteroviruses, etc have incubation times of how long?

Answer 5

1-3 weeks

Question 6

hepatitis, HIV, EBV, rabies have incubation times of how long?

Answer 6

weeks to months

Question 7

note:igm, igg, iga are mediators for humoral immunity against viruses too.

Answer 7

okay

Question 8

which cells are involved with cell-mediated viral immunity?

Answer 8

Th, Tsuppressor, CTL, Tdelayed (hypersensitivity), NK

Question 9

which cytokines play a big role in virus mediation?

Answer 9

IFN1, 2

Question 10

how to store viral samples?

Answer 10

4C if <24 hours;

• 70 if weeks-months;
• 20 is the worst

Question 11

note: always use viral transport medium to keep viral swabs

Answer 11

these have ways to preserve viruses and prevent bacterial growth

Question 12

methods for virus detection in the lab?

Answer 12

light microscopy of viral inclusions;
EM;
immunologic detection;
PCR;
serology for antibodies