W03_05_immunodeficiency II

Question 1

what’s the most important and common complement deficiency state?

Answer 1

late component complement deficiency (LCCD)

Question 2

note: LCCD increases the risk of meningococcal infection but decreases mortality

Answer 2

serogropus causing meningococcal disease in patients with LCCD are uncommon

Question 3

what are the most common and important complications from neutrophil deficiency/dysfunctionality?

Answer 3

staphylococci, gram-negative bactera, fungi

Question 4

what is neutropenia complicated by? Neutrophil dysfunction?

Answer 4

sepsis; localized infection

Question 5

what is the increased risk of prolonged FNP?

Answer 5

invasive pulmonary aspergillosis

Question 6

what are two major immune reconstitution syndromes, post FNP?

Answer 6

asymptomatic pulmonary infiltrates;
hepatosplenic candidiasis