W13/L1: Inflammasome Flashcards
(8 cards)
1
Q
Familial cold urticaria involved a mutation in which protein?
A
NRL-P3 aka cryopyrin
2
Q
What does ICE stand for? What’s another name for it?
A
Interleukin-1 converting enzyme
Caspase1
3
Q
What does activated caspase 1 do?
A
Converts pro-IL-1beta and pro-IL-18 to active forms.
4
Q
What is an inflammasome?
A
An aggregate of caspase 1 in association with NLRs
5
Q
What role to TLRs have in the formation of IL1?
A
They induce expression of pro-IL1, and signal for inflammasome activation
6
Q
What does gout have to do with the inflammasome complex?
A
Crystals (eg MSU) are portent activators of inflammasomes
7
Q
What’s the MoA of anakinra?
A
It’s an IL-1 receptor antagonist
8
Q
In what group is anakinra therapy contraindicated?
A
Those with neutropenia
