W14/L1 Flashcards
(9 cards)
1
Q
What proportion of our normal energy expenditure is comprised of BMR?
A
~70%
2
Q
Apart from BMR, what other two things contribute to energy expenditure?
A
Activity
Thermogenesis
3
Q
What are ob/ob mice deficient in?
A
Leptin
4
Q
What happened to the control mouse in parabiotic experiments with ob/ob mice?
A
It got fat due to decreased leptin concentration
5
Q
What are db/db mice deficient in?
A
Leptin receptor
6
Q
What’a the phenotype of ob/ob mice?
A
Obese
7
Q
What’s the phenotype of db/db mice?
A
Obese with high [leptin]
8
Q
What happened to the control mouse in parabiotic experiments with db/db mice?
A
It died due to excessive leptin signalling -> anorexia
9
Q
What effect does insulin have on body weight?
A
Decreases it
