w23 cell signalling

Question 1

LO

Answer 1

• Understand the basic principles of signal transduction mechanisms,
  in particular the concepts of response specificity, signal amplitude and
  duration, signal integration and intracellular location
• Give examples of different types of extracellular signals and
  receptors, and explain their functional significance
• Describe the mechanisms by which different receptors may be
  activated by their respective ligands
• Describe and give examples of the structure and properties of the
  major components of signal transduction pathways.

Question 2

define signal signal transcduction

Answer 2

conversion of an extracellular signal into
an intracellular signal

Question 3

what order is the path stimuli to response (can name and just order them)

Answer 3

stimuli
sensor
signal transduction
response

Question 4

define cell signalling

Answer 4

ST in cell

Question 5

define signal transduction path or signalling

Answer 5

set of molec events that convert1 specific signal into one spec. cell response

Question 6

define effector

Answer 6

component of SPath that is activated following engagement of receptor

Question 7

how does a molecule coming from a distance become a ligand

Answer 7

by binding a recptor

Question 8

the primary messenger is the ___

Answer 8

ligand

Question 9

ligand binding receptor leads to prod. of more molecules in recieving cell called ?

Answer 9

2nd messengrs

Question 10

prod. of 2nd messengers by Ligand binding receptor affects the expression of specific ____ genes

Answer 10

target

Question 11

define signal transduction in relation to receptor-ligand interaction

Answer 11

ability of cell to translate receptor-ligand interaction to chnge in target gene expression

Question 12

what are the general components in signalling pathways

Answer 12

lgands
receptors
transducers

Question 13

yeast cell mating is regulated by what process

Answer 13

ST

Question 14

what are the 3 stages in yeast cell mating (ST regulated)

Answer 14

xchng of mating factors
mating
new alpha cell

Question 15

can cells communicate indirectly or directly or both

Answer 15

both

Question 16

what type of signals do cells sense and respond in their envt

Answer 16

chem

Question 17

types of cell signalling

Answer 17

endocrine - far away
autocrine - within
paracrine - across
direct contact - next to

Question 18

examples of growth factors and cytokines

Answer 18

Peptides/small proteins secreted from cells,
involved in paracrine and autocrine signalling. e.g. Epidermal Growth Factor (EGF)

Question 19

name 2 type of plasma membrane receptors

Answer 19

Peptides/small proteins secreted from cells,
involved in paracrine and autocrine signalling. e.g. Epidermal Growth Factor (EGF)