W3: Depressive & Bipolar Disorders Flashcards

1
Q

What are the mood disorders in the DSM

A

Unipolar depressive disorders and bipolar disorders

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2
Q

What are the depressive disorders in the DSM

A

Major depressive disorder

Persistent depressive disorder (dysthymia)

Disruptive mood dysregulation disorder

Premenstrual dysphoric disorder

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3
Q

What is major depressive disorder (MDD)? 

A

Clinically significant sadness with associated cognitive and somatic changes

It’s an episodic disorder with periods of normal mood in between periods of the depressed mood

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4
Q

What is the DSM criteria for major depressive disorder

A

Need to have five or more of the following within the same two week period

Depressed mood most of the day, nearly every day
Markedly diminished interest or pleasure in all or almost all activities most of the day, nearly every day (anhedonia)
Significant weight loss or gain or increase/decrease in appetite
insomnia or hypersomnia nearly every day
Psycho motor agitation or retardation nearly every day
Fatigue or loss of energy nearly every day
Feelings of worthlessness or excessive or inappropriate guilt nearly every day
Diminished ability to think, concentrate, or indecisiveness nearly every day
Recurrent thoughts of death, suicidal ideation, suicide attempt or plan

Causes clinically significant distress, not attributable to substances or other medical conditions or mental disorder

There has never been a manic or hypomanic episode!!!!!!


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5
Q

What is the prevalence of MDD

A

14.4%

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6
Q

What is the mean onset of MDD

A

The main age of onset is 30.5 but this age seems to be decreasing this could be because people are becoming more aware and are willing to seek help earlier

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7
Q

Are there any gender differences in MDD

A

There are higher rights in women but is this a genuine reflection of prevalence or are women socialised to get help

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8
Q

Explain relapse in MDD

A

The risk of relapse is high but it is lowered went successfully completing CBT compared with medication

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9
Q

What is suicide ideation

A

Thoughts about ending your life this is common in depression

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10
Q

What is suicide attempt

A

An attempt was made to end your life but it is not completed

Women attempt suicide more than men

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11
Q

What is suicide

A

Successful death from a suicide attempt

Completed suicides are more likely in men

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12
Q

What is nonsuicidal self injury

A

The aim is to cause harm for not to die there may be a range of reasons for this but the main one seen is a release of pain

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13
Q

Differential diagnosis between bipolar and major depressive disorder

A

When you have someone with a major depressive episode it is important to always assess for a history of mania and or hypo mania - if the patient has had a manic or hypomanic episode it will exclude them from a diagnosis of MDD

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14
Q

What does the DSM say about persistent depressive disorder (dysthymia)?

A

Depressed mood for most of the day, for more days the not, as indicated by subjective account or observation by others, for at least two years

Two or more of the following: 
Poor appetite or over eating
Insomnia or hypersomnia
Low energy or fatigue
Low self-esteem
Poor concentration or difficulty making decisions
Feelings of hopelessness

During the two year period the individual has not been without symptoms for more than two months at a time

There has never been a manic or hypomanic episode

The disturbance is not better explained by schizoaffective disorder, schizophrenia, delusional disorder, other psychotic disorder

Not due to substances or medical conditions and cause clinically significant distress or impairment

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15
Q

What is Persistent depressive disorder (dysthymia)?

A

A mild but long-term form of depression.
Dysthymia is defined as a low mood occurring for at least two years, along with at least two other symptoms of depression.

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16
Q

Individuals with MDD and PDD often experience comorbidity disorders such as

A

Anxiety disorders
Substance use disorders
Personality disorders (borderline & dependent)

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17
Q

Explain the specifier of MDD and PDD of anxious distress

A

2 of the following;
Feeling keyed up or tense
Feeling unusually restless
Difficulty concentrating because of worry
Fear that something awful might happen
Feeling that the individual might lose control of himself or herself

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18
Q

Explain the specifier of MDD and PDD of mixed features

A

3 manic/hypomanic symptoms:
Elevated, expansive mood
Inflated self-esteem or grandiosity
More talkative than usual or pressure to keep talking
Flight of ideas or subjective experience that thoughts are racing
Increase in energy or goal directed energy
Increased or excessive involvement in activities that have a high potential for painful consequences
Decreased need for sleep 

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19
Q

Explain the specifier of MDD and PDD of melancholic features

A

1 of the following when episode is most severe

  • loss of pleasure in all, or almost all, activities
  • loss of reactivity to usually pleasurable stimuli

3+:
– Depressed mood characterised by profound despondency, despair, and or empty mood
– Depression that is regularly worse in the morning
– Early-morning awakening
– Marked psychomotor agitation or retardation
- Significant anorexia or weight gain
– Excessive or inappropriate guilt

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20
Q

Explain the specifier of MDD and PDD of atypical features

A

Mood reactivity (mood brightens in response to actual or potential positive events)

2 or more:
Significant weight gain or increasing appetite
Hypersomnia
Leaden paralysis (heavy feelings in arms and legs)
A long-standing pattern of interpersonal rejection sensitivity that results in significant social occupational impairment

Criteria is not met with melancholic features or with catatonia

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21
Q

Explain the specifier of MDD and PDD of psychotic features

A

Delusions and hallucinations are present

With mood congruent psychotic features, content is consistent with depressive themes

  • inadequacy
  • guilt
  • disease
  • death
  • deserved punishment

With mood incongruent psychotic features, content is not consistent with depressive themes

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22
Q

Explain the specifier of MDD (only) of Catalonia?

A

Catatonic features
dominated by 3 or more:
- stupor (no psychomotor activity, not actively relating to the environment)
- catalepsy (passive induction of a posture held against gravity)
- waxy flexibility (slight, even resistance to positioning by the examiner)
- mutism (no, or little verbal message)
- negativism (opposition or no response to instructions or external stimuli)
- posturing (spontaneous and active maintenance of a posture against gravity)
- mannerism (odd, circumstantial caricature of normal actions)
- stereotypy (repetitive, abnormally frequent, non-goal directed movements)
- agitation (not influenced by external stimuli)
- grimacing (pulling unusual faces)
- echolalia (mimicking others speech)
- echopraxia (mimicking others movement)

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23
Q

Explain the specifier of MDD and PDD of peripartum onset

A

Onset of symptoms occurs during pregnancy or in the 4 weeks following delivery

24
Q

Explain the specifier of MDD (only) of seasonal pattern

A

There has been a regular temporal relationship between the onset of major depressive episodes and a particular time of the year
- usually autumn and winter 
See full remission occur at characteristic times of the year usually spring and summer

This pattern needs to be seen for at least two years and seasonal episodes need to outnumber non-seasonal episodes

25
Q

Are there any criticisms to these PDD and MDD specifiers

A

Not well validated

  • seasonal pattern is probably the most well researched and validated
26
Q

What is the paediatric diagnosis of depression

A

Disruptive mood dysregulation disorder – diagnosed in children from 6 to 18 years

27
Q

What is disruptive mood dysregulation disorder

A

Characterised by persistent irritability and frequent episodes of extreme out of control behaviour – included to address concerns about over diagnosis of bipolar disorder in kids

28
Q

What does the DSM say about disruptive mood dysregulation disorder

A

Severe recurrent temper outburst manifested verbally and or behaviourally but are grossly out of proportion in intensity or duration to the situation or provocation

The temple outbursts are inconsistent with their developmental level (out this characteristic of a three-year-old would be concerning seen in a 17-year-old)

The temper outbursts occur on average three or more times per week

 The mood between temper outbursts is persistently irritable or angry most of the day, nearly every day, and is observable by others

Present for more than 12 months and throughout this time the individual has not had a period lasting three or more months without symptoms

Severe outbursts and irritable or angry mood in between are present in at least two settings for example at home and at school and are severe in at least one of these

29
Q

What are the bipolar disorders in the DSM

A

Bipolar I
Bipolar II
Cyclothymic disorder 

30
Q

What are bipolar disorders

A

The bipolar disorders are characterised by the presence of a manic or hypomanic episode

31
Q

What are manic or hypomanic episodes

A

There are periods of intense elation and/or irritation

32
Q

What is the difference between bipolar I and bipolar II

A

The main difference between bipolar 1 and bipolar 2 disorders lies in the severity of the manic episodes caused by each type. A person with bipolar 1 will experience a full manic episode, while a person with bipolar 2 will experience only a hypomanic episode (a period that’s less severe than a full manic episode).

33
Q

What is the DSM criteria for manic episode

A

Period of abnormal and persistent elevated, expansive, irritable mood and increase goal directed activities or energy, lasting at least one week (or any duration of hospitalisation is required)

3+ of following noticeable change from usuals behaviour:
-Inflated self-esteem or grandiosity
– Decreased need for sleep
– More talkative than usual or pressure to keep talking
– Flight of ideas or subjective experience that thoughts are racing usually evident in speech
-Distractibility
– An increase in goal directed behaviour or psychomotor agitation
-Excessive involvement in activities that have a high potential for painful consequences

Severe enough to cause marked impairment in functioning or to necessitate hospitalisation to prevent harm to self or others – symptoms not due to substance or other medical condition


34
Q

What is the DSM criteria for bipolar II

A

This is a more mild version of bipolar I

The DSM criteria states that criteria have been met for at least one hypomanic episode and at least one major depressive episode
There has never been a manic episode

35
Q

What does the DSM say for a hypomanic episode

A

abnormally and persistently elevated, expansive or irritable mood and increased goal directed activity or energy lasting at least four consecutive days

three of the following are present to a significant degree
-Inflated self-esteem or grandiosity
-Decreased need for sleep
– More talkative than usual or pressure to keep talking
– Flight of ideas or subjective experience that thoughts are racing
-Distractibility
-Increased in goal directed behaviour or psychomotor agitation
-Excessive involvement in activities that have a high potential for painful consequences

equitable change in functioning that is uncharacteristic of the individual were not symptomatic

The disturbance in mood and the change in functioning is observable to others

The episode is NOT severe enough to cause marked impairment in social or occupational functioning or two necessitate hospitalisation
Not attributable to the Physiological effects of a drug

36
Q

What does the DSM say about cyclothymic disorder

A

Akin to persistent depressive disorder in the depressive disorders is a chronic disorder

For at least two years or one year in children or adolescence, there has been numerous periods with hypomanic symptoms that do not meet criteria for a hypomanic episode in numerous periods with depressive symptoms that do not meet criteria for major depressive episode

During this time the hypomanic or depressive episodes have been present for at least half the time and the individual has not been without symptoms for more than two months at a time

37
Q

When is the typical onset of bipolar spectrum disorders

A

Most people develop symptoms before the age of 25

38
Q

why are suicide rates so high in the bipolar spectrum disorders

A

They may do things in manic episodes that are then reflected on episodes of depression

39
Q

Why are individuals with bipolar spectrum disorders often reluctant to take medication

A

They may receive a sense of achievement due to the mania productivity and feel this is a loss if they take medication but they are happy that depressive symptoms ease

40
Q

Explain the specifier rapid cycling

A

Can be applied to bipolar I or II
Presence of at least 4 mood episodes in the previous 12 months that meet criteria for manic, hypomanic or major depressive episode – basically faster turnaround between the episodes

41
Q

Are there any genetic links in depression

A

Twin studies demonstrate that about 30 to 40% of the variance in depression is accounted for by genetics

42
Q

Is bipolar heritable

A

Twin studies demonstrate that bipolar is highly heritable up to 90%

43
Q

Explain the role of dopamine in depressive disorders

A

Dopamine is involved in the reward system of the brain this is involved in pleasure, motivation and energy there is evidence that people with depression have reduced dopamine

44
Q

Explain the role of serotonin in depressive disorders

A

Serotonin is involved in the regulation of emotional reactions it is hypothesised that people with a vulnerability to depression have serotonin receptors that are less sensitive than others without such a vulnerability

45
Q

Explain dopamine in bipolar

A

Increasing dopamine levels leads to manic symptoms

It is hypothesised that in bipolar disorder dopamine receptors are too sensitive and you can be genetically predisposed to this as well which may point more towards the genetic link of bipolar 

46
Q

Explain brain functioning in depressive disorders

A

Brain imaging studies show that people with depressive symptoms demonstrate changes in brain functioning

Such as elevated amygdala which is for emotional responses as well as elevated anterior cingulate 

May also see diminished hippocampus activity for memory and dorsolateral pre-frontal cortex activity for higher order thinking such as decision-making planning and motivation

47
Q

Explain brain functioning in bipolar

A

Similar to depression but in mania the striatum aka basal ganglia is also implicated

48
Q

Explain endocrine models for depressive disorders

A

The amygdala regulates the HPA axis and the HPA axis triggers cortisol - there is a link between depression and high levels of cortisol

49
Q

What is the triple vulnerability theory of bipolar and depressive disorders

A

Biological vulnerability such as genes, psychological vulnerability such as coping skills, and stressful life events such as trauma all combine and lead to ….

physiological effects such as the release of stress hormones, cognitive effects such as depression negative thoughts hopelessness etc and mania such as inflated self belief and impulsivity

and social effects such as increased difficulty in relationships and reduce support

all of these lead to bipolar or depressive disorder

50
Q

What medications are there for depressive disorders

A

SSRIs - is the most common and stop serotonin from being reabsorbed so that it can be used for longer

However it does take 4 to 6 weeks to work and symptoms can return when medication is withdrawn

51
Q

What are the medical treatments for depression

A

ECT or electroconvulsive therapy
It involves inducing a mild seizure by sending an electric current through the brain.
The aim is to disrupt the circuitry of the brain and is only used in extreme cases for medication resistant depression
– Often short-term confusion and memory loss associated

TMS
Involves a magnet over the brain that provides a pulse to the dorsolateral pre-frontal cortex it is less invasive than ECT and has emerging evidence in the treatment of depression

52
Q

What medication is there for bipolar disorders

A

Medication is the first line of treatment for bipolar
Mood stabilisers are the most common
E.g. Lithium
toxic and requires ongoing monitoring of blood levels - not an easy medication to take and may be problems with compliance

There will also still be residual symptoms that often persist despite the adequate use of medication

53
Q

What is the cognitive model of depression

A

Maintained by distorted thinking - automatic thoughts, assumptions and core beliefs

This model states if you change distorted thinking you improve mood and reduce depressive behaviours

Core beliefs, assumptions and automatic thoughts lead to a reaction whether emotional behavioural and physiological

54
Q

Give an example of the cognitive model of depression

A

The situation is a friend doesn’t return your call

Your core belief is that you’re worthless
Your assumption is that if you are not popular then you’re nothing
And your automatic thought to your friend not returning your call is that she hates you

Your reaction to this may be:
Emotional-anxious and sad
Behavioural – delete friend off of Facebook
Physiological – tense

55
Q

So what is cognitive behavioural treatment for depression

A

Getting the client to look at evidence for and against the belief - aim is to develop a more adaptive way of thinking (not positive thinking, rational thinking)

Behavioural activation is the main behavioural treatment for depression this involves getting the client to gradually engage in more and more activities over time



56
Q

What is CBT for bipolar disorders

A

Treatment interventions differ according to the current mood state

  • depressed: CBT treatment for depression with behavioural activation and thought challenging
  • manic: usually hospitalisation is required

Psychologist = enhance compliance with medications by psycho education and helping them to understand benefits

They also may be able to help prevent relapse through circadian rhythm management, sleep, exercise, diet, stress management