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WBC 1 Flashcards

1
Q

Severe chronic congenital neutropenia is also known as

A

Kostmann Syndrome

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2
Q

Deficiency of this vitamin can cause ineffective granulopoesis

A

B12 (cobalamin)

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3
Q

Lack of response to an infection due to an overwhelming infection (consumption of WBC)

A

In a state of anergy WBCs are consumed in the peripheral blood to the point they are decreased.

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4
Q

Toxic granules seen in neutrophils as seen during a shift in bone marrow activity

A

Dohle bodies are formed by the activation of enzymes in the ER

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5
Q

Dohle bodies are usually seen in:

A

severe infections (sepsis), or severe inflammatory reactions (Kawasaki’s)

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6
Q

Agranular, enlarged lymphocytes as a result of antigen stimulation (normal N/C ratio)

A

Reactive lymphocytes

Or Atypical lymphocytes

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7
Q

The presence of what cells may indicate neoplastic proliferation?

A

blasts

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8
Q

Defined by the presence of large oblong germinal centers surrounded by a collar of small resting naive B cells

A

Follicular hyperplasia

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9
Q

Hyperplasia of cells lining the lymphatic sinusoids where HISTIOCYTE (tissue macrophage) number is greatly increased

A

Sinus histiocytosis.

(Active B cells in center
Inactive B cells in periphery)

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10
Q

Pattern of chronic lymphadenitis usually caused by drugs, IM, vaccines

A

Parafollicular hyperplasia

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11
Q

Follicular hyperplasia is the stimulation of which compartment?

A

B-cell (compartment of lymph nodes)

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12
Q

Dark zone of germinal region contain these proliferating B cells

A

Centroblasts

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13
Q

Abnormal expansion of the interfollicular zones but is confined within the lymph node capsule

A

Parafollicular hyperplasia

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14
Q

Marginal layer gets thinner; germinal center gets larger.

A

Follicular hyperplasia

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15
Q

Lymph node hyperplasia prominent in breast carcinoma

A

Sinus hyperplasia

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16
Q

Foreign bodies are attacked by killer T cells here

A

parafollicular

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17
Q

Folluclar hyperplasia is a chronic reaction that can be seen in these infections: (examples)

A

HIV, toxoplasmosis

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18
Q

Light zone of germinal centers contain these B cells with irregular or cleaved nuclear contours

A

Centrocytes

Some will be come memory cells

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19
Q

Macrophages that eat up failed B cells that have undergone apoptosis are called:

A

tingible bodies

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20
Q

Lymphoid neoplastic proliferation arising as discrete tissue masses in LYMPH NODES

A

lymphoma

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21
Q

Type of myeloid neoplasm: immature progenitor cells accumulate in the BM

A

Acute myeloid leukemia

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22
Q

Increased WBC count with left shift (80% bands)

increased leukocyte alkaline phosphatase

A

Leukemoid reaction

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23
Q

Reed-Sternberg cells (RS cells) are required for diagnosis of:

A

Hodgkin’s lymphoma

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24
Q

Neoplasms that present with widespread involvement of the bone marrow and peripheral blood; arise in BONE MARROW

A

Lymphocytic leukemia

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25
Type of myeloid neoplasm: associated with ineffective hematopoiesis and resultant peripheral blood cytopenias
Myelodysplastic syndrome
26
WHO class of lymphoma which includes: adult T cell lymphoma (ATL) Anaplastic large cell lymphoma (ALCL) Sezary's and Mycosis fungoides
Peripheral T cell lymphoma (MATURE T cell)
27
Clover leaf or flower cells in PBS
Adult T-cell lymphoma
28
Type of myeloid neoplasm: increased production of one or more terminally differentiated myeloid elements which usually leads to elevated peripheral blood counts
Chronic myeloproliferative disorder
29
Distinct tumor giant cell. Binucleate, mirror imaged. Owl eyes.
Reed-Sternberg cells induce the accumulation of other inflammatory cells
30
WHO class of lymphoma which includes B lymphoblastic leukemia (ALL) / lymphoma
Precursor B cell (Neoplasm of IMMATURE B cell)
31
Sezary's and Mycosis fungoides manifest what lesions?
Skin lesions (T cells tend to go to skin)
32
WHO class of lymphoma which includes hairy cell leukemia, Burkitt's and Follicular Lymphoma.
Peripheral B cell CLL, SLL (Neoplasm of MATURE B cell)
33
Leukocyte common antigen
CD45
34
T cell antigen
CD5 CD4 / CD8 CD3
35
B cell antigen
CD10 CD19 CD20 (pre B, mature B) IgM
36
Monocyte antigen
CD14 | CD64
37
Stem cell antigen
CD34
38
Hodgkin antigen
CD15, CD30
39
Peripheral T cell antigen
CD3
40
Pan-B marker
CD19
41
Ratio of kappa light chain B cells to lambda light chain B cells (benign)
2:1 2/3 are kappa 1/3 are lambda (When one light chain is significantly more common than the other, it suggests derivation from a monoclonal population indicating MALIGNANCY)
42
Small, painful, solitary lymphatic enlargements indicate:
Benign | lymphoma presents as multiple and painless
43
A nodular white lymph node specimen when cut probably indicates:
lymphoma
44
Bcl-6 (30%) | t(14:18) (10%)
DLBCL also bcl-2
45
Starry-sky appearance on PBS
Burkitt's lymphoma
46
Neoplasm that presents in children <15 years
Acute Lymphoblastic Lymphoma/Leukemia
47
Caused by HTLV-1
Adult T cell lymphoma
48
Marker of pre-T and pre-B cells
TdT+ Terminal Dioxynucleotidil Transferase
49
(+) TdT, (+) CD5
T-ALL | pre-T cell lymphoma
50
Peaks at 4 years old
pre-B ALL At 4 years old B cells are maximal in bone marrow
51
(+) CD15 could indicate
Hodgkin's lymphoma
52
(+) CD5, (+) CD23 vs (+) CD5, (-) CD23
SLL vs Mantle cell lymphoma
53
Pre-T ALL usually has this clinical manifestation
mediastinal mass Rapidly fatal if left untreated. Good remission with treatment.
54
Follicular lymphoma progression to DLBCL because of this gene rearrangement or mutation
c-MYC
55
c-myc activation
Burkitt's
56
(+) TdT, (+) CD19
Pre-B cell lymphoma
57
Jaw lesion of Burkitt's lymphoma is:
endemic form
58
bcl-2 expression seen in which lymphoma?
Follicular lymphoma | can be seen in DLBCL
59
Difference between SLL and CLL
CLL has increased peripheral blood WBC CLL is a stage of SLL
60
t(11;14)
Translocation of 11 and 14 cyclin D1 upregulation --> promotion of G1 to S Mantle Cell Lymphoma
61
t(8;14)
translocation | c-myc activation (inactivates p53)
62
Affects male:female::2:1, >60 y/o, and often asymptomatic.
SLL/CLL
63
Cyclin D-IgH function? | Associated with what type of lymphoma?
Promotes G1 to S Mantle Cell Lymphoma
64
ALK positivity is typical but not required in
Anaplastic large cell lymphoma
65
EBV
Burkitt's Lymphoma EBV stimulatesNF-kappa B
66
t(9;22)
Translocation of 9 and 22 | CML (Philadelphia chromosome)
67
In the indolent course, this lymphoma is incurable
Follicular lymphoma
68
NHL with BIPHASIC prevalence: elderly and pediatric
DLBCL
69
Sporadic form of this neoplasm affects the pelvis or abdomen
Burkitt's lymphoma
70
t(14;18)
``` Translocation Follicular Lymphoma (bcl-2 activation inhibits apoptosis) ```
71
Progression (complication) where lymphoma transforms into DLBCL
Richter Syndrome | from HCL, CLL/SLL
72
Trisomy 12
CLL/SLL
73
Clinical manifestation of Extranodal NK/T cell Lymphoma
nasal: nasopharanx, oropharynx, nose, oral cavity Cutaneous like Sezary and Mycosis fungoides
74
Lymphoma associated with warm IHA/AIHA
CLL/SLL
75
This has 3 Clinical stages: inflammatory, plaque, tumor
Mycosis fungoides
76
Skin lesions + hypercalcemia
Adult T-cell lymphoma
77
CNS + testicular involvement is a manifestation of:
ALL
78
Hallmark cell is horseshoe-shaped nuclei
Anaplastic large cell lymphoma
79
Smudge cells in PBS
CLL/SLL
80
WHO class of lymphoma which includes T lymphoblastic Leukemia/Lymphoma
Precursor T cell (neoplasm of IMMATURE T cell)
81
Clinical feature of this HL: mediastinal or cervical mass
Nodular sclerosis HL
82
Non-classical Hodgkin's Lymphoma subtype
Lymphocyte predominant HL has (-) CD15 and (-) CD30
83
Hodgkin lymphoma subtype with presence of frequent mononuclear variants and RS cells with CLASSICAL IMMUNOPHENOTYPIC profile
Lymphocyte rich HL in Lymphocyte predominant HL, classical RS cells are difficult to find
84
Hodgkin's lymphoma associated with HIV+
Lymphocyte depletion HL
85
Most common HL
Nodular sclerosing HL
86
Histological feature of this HL: Frequent RS cells surrounded by reactive cells (eosinophils, lymphocytes, histiocytes)
Mixed-cellularity HL
87
Histology of this HL reveals collagen banding and lacunar cells
Nodular sclerosing HL
88
Popcorn cell =
Lymphocyte predominant HL | multilobed nucleus
89
These two subtypes of Hodgkin's lymphoma are usually not associated with EBV
Nodular sclerosing and Lymphocyte predominant
90
Classic HL that is commonly (-) for EBV
Nodular sclerosing HL
91
HL with poorest prognosis
Lymphocyte depletion HL

3 Patho (8 decks)

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