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WBC Flashcards

(43 cards)

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1
Q

leukocyte morphologic abnormality

  • hyposegmented + hyperclumped
  • “pince-nez” morphology
  • mimics leukemoid reaction (shift to left)
A

Pelger-Huet Anomaly

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2
Q

leukocyte morphologic abnormality

  • granulocytes have dark staining granules
  • due to incomplete degradation of mucopolysaccharides
  • associated with Hurler, Hunter, and Sanfilippo syndrome
A

Alder-Reilly Anomaly

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3
Q

leukocyte morphologic abnormality

  • red needles in cytoplasm
  • observed in blast cells in AML, especially APL
  • faggot cells
A

Auer Rods

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4
Q

leukocyte morphologic abnormality

disorder in the production of myosin heavy chain type IIa

A

May-Hegglin Anomaly

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5
Q

leukocyte morphologic abnormality

Triad of May-Hegglin Anomaly

A
  1. Dohle-like Bodies
  2. Thrombocytopenia
  3. Giant Platelets
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6
Q

leukocyte morphologic abnormality

  • light blue patches in cytoplasm of neutrophils
  • RNA remnants
A

Dohle bodies

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7
Q

leukocyte morphologic abnormality

immature granulocytes in peripheral blood

A

shift to the left

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8
Q

lymphocyte morphologic abnormality

lymphocytes that exhibit reactive morphology

A

downey/turk cell

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9
Q

lymphocyte morphologic abnormality

  • caused by pressure in smear prep.
  • indicates nuclear fragility
  • ⬆️ in CLL
A

basket/smudge cell

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10
Q

lymphocyte morphologic abnormality

  • plasma cell with irregular cytoplasmic projections
  • contain more immunoglobulins than normal plasma cells
  • associated with multiple myeloma
  • bright purple-red in Wright’s stain
A

Flame cell

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11
Q

lymphocyte morphologic abnormality

plasma cell with round globules
(also associated with multiple myeloma)

A

Grape/mott/rusell bodies

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12
Q

lymphocyte morphologic abnormality

lymphocyte with convoluted, cerebriform nucleus (assoc with sezary syndrome and mycoses fungoides)

A

sezary cell

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13
Q

most common type of leukemia in adults

A

acute myeloid leukemia

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14
Q

surface markers in AML

A

CD13, CD33, CD117

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15
Q

other name for FAB M4

A

Naegelli leukemia

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16
Q

other name for FAB M5

A

Schilling’s leukemia

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17
Q

other name for FAB M6

A

Di Guglielmo Syndrome

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18
Q

25-75% of childhood leukemia

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A

Acute lymphoblastic leukemia

19
Q

location of genetic abnormality in ALL

20
Q

cytochem stain for phospholipids and lipids

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A

Sudan Black B

21
Q

oncogene formed from chronic myelogenous leukemia

22
Q

chromosome associated from chronic myelogenous leukemia

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A

Philadelphia chromosome [t(9;22)]

23
Q

diff. of CML and leukemoid reactions

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A

CML has low NAP/LAP score

24
Q

dye used in neutrophil alkaline phosphatase

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A

diazo (alkaline pH)

25
poikilocyte present in myelofibrosis
dacryocytes
26
most aggressive form of myeloproliferative neoplasm (MPN)
myelofibrosis
27
- MPN with malignant hyperplasia - high RBC but low EPO - hyperviscosity
polycythemia vera
28
- clonal MPN with increased megakaryopoiesis and thrombocytosis - giant bizarre platelets
essential thrombocythemia
29
group of acquired clonal hematologic disorder with **progressive cytopenia** + dyserythropoiesis, dysmyelopoiesis, dysmegakaryopoiesis
myelodysplastic syndrome
30
positive in PAS
ALL and M6
31
2 lymphocyte morphologic abnormality
1. flame cell 2. grape/mott/russel bodies
32
classification of acute leukemia in >30% BM blasts
FAB
33
classification of acute leukemia in >20% BM blasts
WHO
34
oncogene found in polycythemia vera and essential thrombocytopenia
JAK2 (Janus Kinase 2)
35
35
2 mature T cell lymphoma
1. Mycosis fungoides 2. Sezary syndrome
36
most common type of cutaneous lymphoma
mycosis fungoides
37
aggressive lymphoma with leukemic presentation and peripheral blood involvement
Sezary syndrome
38
excess immunoglobulins found in multiple myeloma
IgG and IgA
39
excess immunoglobulin found in Waldenstrom's Macroglobulinemia
IgM
40
Surface markers found in plasma cells in cases of multiple myeloma
CD 38 and CD138
41
lymph node-based disease that have the presence of **reed-sternberg cells**
Hodgkin's lymphoma
42
surface markers in B-cells in cases of Hodgkin's lymphoma
CD15 and CD30

Hematology (9 decks)

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