WBC Abnormalities: Granulocytes Flashcards
(28 cards)
Autosomal Dominant ; Hyposegmentation with Peanut/Dumble/Spectre
Pelger-Huet
Pelger-Huetn Homozygous pH
Round Nucleus
Pelger-Huet Heterozygous pH
2 Lobes; common
Seen in Myeloproliferative disorders (CML)
Acquired Hyposegmentation
Pseudo-Pelger-Huet Anomaly
Neutrophils with MORE THAN 5 LOBES
Hypersegmentation
Old segmented neutrophils
Pseudohypersegmentation
Hereditary Hypersegmentation
Undritz anomaly
Acquired Hypersegmentation
Vit.B12 deficiency/Folic Acid Deficiency
CYTOPLASMIC ABNORMALITIES (4)
Alder-Reilly
Auer Rods
May-Hegglin Inclusions
Toxic Granules
purple-red particles with MUCOPOLYSACCHARIDE
Alder-Reilly
Associated with Hunter’s, Hurler and Maroteaux-lamy type
RESEMBLES TOXIC GRANULES
Alder-Reilly
ABNORMAL LYSOSOMAL DEVELOPMENT
Chediak-Higashi Syndrome
Characterized with Albinism
Gigantic Platelets
Impaired Chemotaxis and Delayed Killing of ingested bacteria
Chediak-Higashi Syndrome
Differentiate Alder-Reilly Vs Toxic Granules
Alder-Reilly are found in MONOCYTES AND LYMPHOCYTES
Toxic Granules are found in NEUTROPHIL
Pink or Red Rod Shaped; Peroxidase Positive seen in MYELOID AND MONOCYTIC SERIES
Auer Rods
Mass of AUER RODS
Faggot Cells
Seen in
- M3: APL (Acute Promyelocyte Leukemia)
- DIC
AUER RODS
Seen in patient with Infections and Burns (3)
Toxic Granules
Toxic Vacuoles
Dohle Bodies
Precipitation of MYOSIN
Giant Platelets
Resembles Dohle Bodies
May-Hegglin Inclusions
Aggregates of Rough Endoplasmic Reticulum ; Light-blue staining On Wright’s stain smear
Dohle Bodies
dark granulation, azurophilic (primary) granules
Toxic granules
Neutrophils have poor directional motility ; normal random motility
Job Syndrome
Abnormal Directional and Random Motility
Lazy Syndrome
Unable to kill catalase (+) organism
Chronic Granulomatous Disease
