WBC Markers

Question 1

Acute Myelogenous Leukemia

Answer 1

Auer Rods; CD13, CD33, CD11b

Question 2

Acute Promyelogenous Leukemia

Answer 2

t(15;17); DIC, Gout, DVT.

Question 3

Myelodysplastic Syndrome

Answer 3

Erythroblasts, Myeloblasts, Megakaryocytes

Question 4

Acute Lymphocytic Leukemia

Answer 4

Intracellular TdT & CD22

Question 5

Hairy Cell Leukemia

Answer 5

Dry Tap; BRAF mutation; TRAP, CD19, CD20. Usually seen in older males, presents with pancytopenia

Question 6

Hodgkin’s Lymphoma

Answer 6

Reed-Sternberg Cells; CD15, CD30

Question 7

Ann-Arbor Staging: Class I

Answer 7

Involvement of single lymph node region or single extralymphatic site/organ

Question 8

Ann-Arbor Staging: Class II

Answer 8

Involvement of 2 or more lymph node regions on the same side of diaphragm

Question 9

Ann-Arbor Staging: Class III

Answer 9

Involvement of lymph node regions on both sides of the diaphragm with or without local invasion of extralymphatic sites

Question 10

Ann-Arbor Staging: Class IV

Answer 10

Diffuse involvement of one or more extralymphatic organs with or without lymph node involvements

Question 11

MALToma

Answer 11

CD19, CD20; Marginal Zone –> Memory B-Cell

Question 12

Follicular Lymphoma

Answer 12

t(14;18), Bcl-2 mutation; centrocytes and centroblasts

Question 13

Chronic Lymphocytic Leukemia

Answer 13

Smudge cells; CD19, CD20, CD23, CD5; spherocytes due to autoimmune hemolytic anemia, hepatosplenomegaly

Question 14

Warm Agglutinins

Answer 14

SLE, CLL

Question 15

Cold Agglutinins

Answer 15

TB, Mycoplasma, Mono

Question 16

Burkitt’s Lymphoma

Answer 16

t(8;14); due to EBV; starry sky, macrophages, with Ki67. Develop Anemia of Chronic Disease

Question 17

Multiple Myeloma

Answer 17

Punched-out lytic lesions, Russel Bodies (intracellular cytoplasmic Mott cells), kappa-light chain, IgG, Rouleaux formation, “M-spike”; CRAB

Question 18

Waldenstorm’s

Answer 18

Macroglobinemia (IgM); associated with DVT and blindness

Question 19

Adult T-Cell Leukemia

Answer 19

HTLV-1; problem with TAX gene which inhibits p53; flower cells.

Question 20

Mycoides Fungiodes

Answer 20

Sezary cells with cerebriform nuclei; CD3, CD4; SKIN INVOLVEMENT

Question 21

Leukemoid Rxn

Answer 21

WBC count greater than 50,000; LAP (+)

Question 22

Secondary Polycythemia

Answer 22

Increased EPO, Increased Hct due to high altitude and RCC

Question 23

Essential Thrombocytopenia

Answer 23

Bone marrow contains increased platelets and megakaryocytes

Question 24

Myelofibrosis

Answer 24

JAK 2 mutation; teardrop cells and marrow fibrosis. Leukoerythroblastic reaction, increased AML risk

Question 25

Dysplastic Erythropoeisis

Answer 25

Ringed Sideroblast (not diagnostic)

Question 26

Psuedo-Pelger-Heut

Answer 26

Can transform to AML; neutrophils, not band form (pushed to one side of nucleus)

Question 27

Langerhan's Histiocytosis

Answer 27

Macrophages in tissue and liver; Bierbeck granules

Question 28

Bernard-Soulier

Answer 28

Gp1 on platelet; qualitative, not correctable

Question 29

Risoceitin

Answer 29

Amplified adheshion of vWF; BT, and PTT due to Factor VIII

Question 30

Hemophilia

Answer 30

Hemarthrosis; affected mother with normal father has 50% chance of passing onto all children (25% chance of passing onto son)

Question 31

Chronic ITP vs Acute ITP

Answer 31

IgG for chronic, mother passes along; IgM for acute

Question 32

Uremic Platelet Destruction

Answer 32

Increased BT, BUN. NORMAL PLATELETS