WBC Part 1

Question 1

t(14;18) is associated with what cancer and oncogene

Answer 1

follicular lymphoma

blc-2

Question 2

t(8;14) is associated with what cancer and oncogene

Answer 2

burkitt lymphoma

c-myc

Question 3

t(11;14) is associated with what cancer and oncogene

Answer 3

mantel cell lymphoma

Cyclin-D1

Question 4

t(15;17) is associated with what cancer

Answer 4

acute promyelocytic leukemia

Question 5

t(9;22) is associated with what cancer and oncogene

Answer 5

Chronic Myelogenous Leukemia (CML)

BRC-ABL (Philadelphia chromosome)

Question 6

HHV8 virus is associated with what cancer

Answer 6

Pleural Effusion Lymphoma

Kaposi sarcoma

Question 7

HTLV-1 virus is associated with what cancer

Answer 7

Adult T Cell leukemia/lymphoma

Question 8

H. Pylori is associated with what cancer

Answer 8

Marginal Zone Lymphoma (MZL) MALT lymphomas of stomach

Question 9

Hashimotos’s thyroiditis is associated with what cancer

Answer 9

Marginal Zone Lymphoma (MZL) aka MALT lymphoma of the thyroid

Question 10

lymphadenopathy (define)

Answer 10

lymph node enlargement (tender or non-tender)

Question 11

lymphadenitis (define)

Answer 11

lymph node inflammation (typically tender)

Question 12

what causes follicular hyperplasia

Answer 12

stimuli that stimulate B cells

Question 13

in follicular hyperplasia what does the mantle zone look like

Answer 13

polarized

Question 14

describe 2 main characteristics of follicular hyperplasia seen on histological slide

Answer 14

tingible body macrophages
polar mantle region around germinal center
lots of follicles

Question 15

describe bcl-2 staining in follicular hyperplasia and lymphoma

Answer 15

follicular hyperplasia- mantle stains and not germinal center (light germinal center
follicular lymphoma- follicle stains

Question 16

paracortical hyperplasia is due to what

Answer 16

stimuli that stimulate cellular immune response (T-cell expansion)

Question 17

sinus histiocytosis is what and found where

Answer 17

numerous macrophages within sinuses

prominent in nodes draining cancer

Question 18

Acute Nonspecific lymphadenitis is characterized by what?

Answer 18

enlarges, red, tender, soft nodes

follicular hyperplasia

Question 19

What is acute nonspecific lymphadenitis due to

Answer 19

drainage of infections (localized or systemic)

Question 20

acute nonspecific lymphadenitis in the cervical lymph nodes is probably due to what

Answer 20

infections of teeth or tonsils

Question 21

acute nonspecific lymphadenitis in the axillary/inguinal lymph nodes is probably due to what

Answer 21

infections in the extremities or groin

Question 22

acute nonspecific lymphadenitis in the mesenteric lymph nodes is probably due to what

Answer 22

appendicitis or yersinia

Question 23

chronic nonspecific lymphadenitis is characterized by and due to what

Answer 23

non-tender nodes

due to chronic immunologic stimulation

Question 24

WBC cancer involving mostly tissue

Answer 24

lymphoma

Question 25

WBC cancer involving mostly blood/bone marrow

Answer 25

leukemia

Question 26

lymphoma patients clinically present with what

Answer 26

2/3 present with non-tender adenopathy | 1/3 present with extra nodal tissue involvement

Question 27

leukemia patients clinically present with what

Answer 27

bone marrow failure symptoms | can involve liver or spleen

Question 28

EBV is associated with what cancers

Answer 28

Burkitt lymphoma Hodgkin lymphoma immunodeficiency associated B cell lymphomas rare NK cell lymphomas

Question 29

what things cause follicular hyperplasia

Answer 29

toxoplasmosis (infections) early HIV non-specific

Question 30

what are B-symtoms

Answer 30

fever, night sweats, and weight loss

Question 31

80-85% of lymphoproliferative processes are of what origin

Answer 31

B-cell

Question 32

what cancer is associated with downs syndrome in children under 5 years of age

Answer 32

Acute Megakaryoblastic Leukemia

Question 33

what cancer is associated with downs syndrome in children over 5 years of age

Answer 33

Acute Lymphocytic Leukemia

Question 34

the blasts of acute leukemia's have what nuclear characteristic when observed

Answer 34

punched out nucleoli