WBC Part 8

Question 1

splenomegaly presents with what

Answer 1

left upper quadrant dragging sensation

discomfort after eating

Question 2

nonspecific acute splenitis can occur in what and is characterized by what

Answer 2

any blood borne infections

enlarged spleen with softness and congestion of red pulp

Question 3

congestive splenomegaly has what kind of etiology

Answer 3

intrahepatic etiology and extra hepatic etiology

Question 4

Intrahepatic congestive splenomegaly is due to what

Answer 4

right heart failure
hepatic cirrhosis (alcoholic and chronic hepatitis)

Question 5

extrahepatic congestive splenomegaly is due to what

Answer 5

spontaneous portal vein thrombosis

splenic vein thrombosis

Question 6

what happens to degree of firmness in splenomegaly

Answer 6

increases over time due to less efficient passage of the blood
means more time for the macrophages to destroy cells

Question 7

increased pressure in splenomegaly results in what

Answer 7

intraparenchymal hemorrhage

Gandy-Gamma bodies

Question 8

Gandy-gamma bodies are what and seen in what

Answer 8

deposition of pigment and cellular waste such as iron and calcium
seen in splenomegaly

Question 9

splenic infarcts are due to what

Answer 9

sterile or infectious emboli

Question 10

what do splenic infarcts look like

Answer 10

pale, wedge shaped and subcapsular in location

Question 11

splenic infarcts are common in what

Answer 11

enlarged spleens

Question 12

what neoplasms are associated with the spleen

Answer 12

hairy cell leukemia
non hodgkin lymphomas
hodgkin lymphoma

Question 13

splenic rupture is usually due to what

Answer 13

usually precipitated by trauma
infectious mononucleosis
lymphoid neoplasm
massive, rapid, intraperitoneal hemorrhage

Question 14

what developmental disorder of the thymus exist

Answer 14

hypoplasia (DiGeorge Syndrome)

Cysts (Benign but can be associated with neoplasms)

Question 15

thymic hyperplasia refers to what

Answer 15

appearance of secondary follicles (Bcells)

Question 16

thymic hyperplasia is associated with what conditions

Answer 16

Myasthenia gravis
Graves disease
SLE
RA
other autoimmune disorders

Question 17

Thymoma (definition)

Answer 17

tumors of thymic epithelial cells with a background of immature t cells

Question 18

thymomas have what pathology

Answer 18

anterior superior mediastinum of adults
firm gray-white mass up to 20cm in size
areas of cystic necrosis and calcification
mixture of epithelial cells and non-neoplastic lymphocytes

Question 19

what are the categories of thymomas

Answer 19

benign encapsulated

malignant- cytologically benign (but invasive) or cytologically malignant (squamous cell carcinoma)

Question 20

what clinical features are seen in thymomas

Answer 20

impingement on mediastinal structures

association with myasthenia gravis

Question 21

Histiocytosis (define)

Answer 21

umbrella term for reactive process composed of macrophages and/or dendritic cells

Question 22

pulmonary langerhans histiocytosis is seen in what patients

Answer 22

smokers

spontaneous regression with cessation

Question 23

Birbeck granules are what and seen in what

Answer 23

tennis rackets seen on EM

langerhans cell histiocytosis tumor cells

Question 24

Langerhans cell histiocytosis tumor cells express what

Answer 24

S-100 and CD1a

Question 25

MM-LCH (multifocal, multisystem langerhans cell histiocytosis) is seen in what age patients

Answer 25

children under 2

Question 26

Letterer-Siwe disease is associated with what

Answer 26

MM-LCH (multifocal, multisystem langerhans cell histiocytosis)

Question 27

MM-LCH (multifocal, multisystem langerhans cell histiocytosis) presents with what

Answer 27

cutaneous lesions which look like seborrheic eruptions (trunk and scalp) concurrent hepatospleomegaly, lymphadenopathy, pulmonary, lesions, and destructive bony tissues

Question 28

U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes) are

Answer 28

expanding erosive accumulation of neoplastic cells with medullary cavity of the bones (calvarium, ribs, femur most common)

Question 29

Eosinophilic granuloma is a term given to what

Answer 29

lesions of U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes)

Question 30

unifocal and multifocal U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes) occur at what ages

Answer 30

unifocal- children and adults | multifocal- young kids

Question 31

Hand-Schuller-Christian triad is associated with what

Answer 31

multifocal U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes)

Question 32

what is the Hand-Schuller-Christian triad

Answer 32

calvarial bone defect diabetes insipidus exophthalmos