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Pathology > WBC:RBC > Flashcards

WBC:RBC Flashcards

(61 cards)

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1
Q

Cells counted in a CBC

A

Leukocytes, Erythrocyctes, Thrombocytes

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2
Q

Hemoglobin

A

Total hemoglobin concentration in a given unit of blood

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3
Q

Hematocrit

A

% of columne of whole blood comprosed of RBCs

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4
Q

Mean corpuscular volume

A

Average volumn of RBCs, correlating with aerage RBC size.

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5
Q

Mean corpuscular hemoglobin

A

Weight of hemoglobin in the average RBC

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6
Q

Mean corpuscular cellular hemoglobin (MCHC)

A

concentration of hemoglobin in the average RBC

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7
Q

Red Blood Cell Distribution Width (RDW)

A

Variation in size of RBC

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8
Q

Mean-platelet volumne (MPV)

A

measurent of variation in size of platelets (age of platelets)

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9
Q

Leukocyte differential

A

Counts the different WBCs

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10
Q

Differential cell counts

A

relative numbers

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11
Q

Absolute cell counts

A

Multiply % on manual differential by total WBC count

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12
Q

Leukocytosis

A

Increased WBC

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13
Q

Neutrophilia

A

Increased neutrophils

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14
Q

Eosinophilia

A

Increased eosinophils

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15
Q

Basophilia

A

Increased basophils

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16
Q

Monocytosis

A

Increased monocytes

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17
Q

Thrombocytosis

A

Increased platelets

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18
Q

Polycythemia

A

Increased RBC

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19
Q

Neutropenia

A

Decreased neutrophils

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20
Q

Leukocytopenia

A

Decreased WBC

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21
Q

Lyphocytopenia

A

Decreased lymphocytes

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22
Q

Monocytopenia

A

Decreased monocytes

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23
Q

Thrombocytopenia

A

Decreased platelets

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24
Q

Anemia

A

Decreased RBCs

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25
Microcytosis
Smaller than normal RBCs
26
Macrocytosis
Larger than normal RBCs
27
Anisocytosis
Variation in size of RBC
28
Poikilocytosis
Variation in shape of RBC
29
Anisopoikilocytosis
Variation in shape and size of RBCs
30
Normocytic
Normal amount of hemoglobin, with normal staining on peripheral blood smear
31
Hypochromic
Decreased hemoglobin, with pale staining RBCs
32
Polychromasia
Increased immature RBC. Blue-gray cytoplasm due to residual RNA. Normal amount of hemoglobin
33
Microcytic Hypochromic RBCs
Small and pale cells. Iron deficiency, anemia of chronic disease, sideroblastic anemia, lead/heavy metal poisoning, thalassemia
34
Macrocytic RBC
Larger than normal. Well hemoglobinized. Young cells.abnormal maturaion states
35
Spherocytes
Smaller in diameter than normal, more spherical, less loss of central pallor. Lose membrance during passage thru spleen. Destroyed prematurely in spleen.
36
Elliptocytosis/Ovalocytosis
Oval/elliptical cells.
37
Hereditary causes of Elliptocytosis
Cytoskeleton abnormalities due to defectins in proteins
38
Acquired causes of Elliptocytosis
Iron deficiency, Thalassemias, Megaloblastic anemia, Myelofibrosis, Myelodysplastic syndromes
39
Target cells
Large, floppy cells with redundant cytoplasmic membrane. Bell-shaped in bloodstream.
40
Macrocytic Target cell causes
Liver disease, megaloblastic anemia
41
Microcytic Target cell causes
Thalassemia, iron deficiency
42
Normocytic Target cell causes
Sickling disorders, Hgb E
43
Acanthocytes shape
Amoeboid cells with unevenly** distributed spicules over the RBC surface
44
Inherited acanthocyte cause
Abetalipoproteinemia
45
Acquired cause of acanthocyte
Liver disease, mylodysplastic syndromes, malnutrition
46
Echinocytes shape
Cells with even distributed spicules over the entire RBC surface (short and blunt)
47
Causes of echinocytes
Storage artifact, liver disease, renal failure, enzyme deficiencies
48
Stromatocytes shape
"Mouth cells". Central zone of pallor is narrow and linear (-_-)
49
Cause of stromatocytes
Occasionally seen in healthy pts. Seens in EtOH excess/liver disease. Hydroxyurea therapy, myelodysplastic syndroms, inherited disorders
50
Schistocytes
RBC fragment. Result of mechanical disruption of RBC in fibrin strands (DIC), platelet strands (TTP/HUS), toxins, burns, vasculitis, mechanical heart valves
51
Hemoglobin C disease cause
Homozygosity for hemoglobin C varient of beta chain of hemoglobin.
52
Morphology of hemoglobin C disease
Irregularly contracted cells, target cells, hemoglobin C crystals, spherocytes
53
Bite Cell shape
aka Degmacyte. Appear to have a bite out of them. Seen on peripheral blood smears
54
Formation of bite cells
After Heinz bodies are plucked out if the RBCs by reticuloendothelial cells of spleen
55
Where are Heinz bodies seen?
Only on supravital stains. Not on Wright-stained peripheral blood smears
56
What happens to pts with G6PD deficiency?
Nothings unless the pt is exposed to antioxidant stress
57
What gene is G6PD on?
X chromosome
58
Howell-Jolly bodies
RBC inclusion. Small nuclear remnants. Typically single.
59
Pappenheimer granules
Iron-containing mitochondrial remnants. Occur in small clusters near periphery of cell
60
Basophilic stippling
Composed of RNA. Aggregates of ribosomes
61
Cabot ring
Nuclear remnant vs. microtubules

Pathology (4 decks)

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