Weed, Marijuana, Cannibis

Question 1

What is cannabis

Answer 1

A genus of flowering plants that belong to cannabaceae

Question 2

What are the related plants to cannabis

Answer 2

C. sativa, C. indica, C. ruderalis, hemp

Question 3

Where does the medicinal benefit come from

Answer 3

Unfertilized female plants creating cannabinoids

Question 4

What is strain, hybrid

Answer 4

variety of cannabis plants that have a particular characteristic that might be used to express a specific desired effect, cross between tow genetically different strains of cannabis

Question 5

Why is the sativa stimulating, while the indica strain is more relaxing (body high)

Answer 5

Higher in THC, Mix of THC/CBD (higher CBD)

Question 6

What are terpenes

Answer 6

Aromatic hydrocarbons that cause the smell and taste

Question 7

What are cannabinoids most likely to cause the effects of cannabis, how are they made

Answer 7

Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD), trichomes (tiny glands of resinous oil)

Question 8

What are the positive effects of THC

Answer 8

Analgeisa, antiemetic, appetite stimulation, muscle relaxant, sleep aid, euphoria

Question 9

What are the adverse effects of THC

Answer 9

Euproria (low doses), anxiety (too high of a dose), acute pschosis, tachycardia, cannabinoid hyperemsis syndrome

Question 10

How can someone tell if a patient has cannabinoid hyperesis syndrome

Answer 10

They feel better after a hot shower

Question 11

What are the positive effects of CBD

Answer 11

Analgesia, anticonvulsant, less anxiety, muscle relaxant, may reduce undesirable pschoactive effects of THC

Question 12

What are the adverse effects of CBD

Answer 12

Diarrhea, headache, fatigue, drowsiness, loss of appetite, possible liver injury

Question 13

What is the THC analog available in the US, what is the route, indicalation

Answer 13

Cesamet (Nabilone), oral, Chemotherapy Induced Nausea and Vomiting (CINV)

Question 14

What are the synthetic THCs approved in the US, what is the route of administration, indication

Answer 14

Marinol and Syndros (Dronabinol), Oral, CINV and anorxeia

Question 15

What is the concentrated CBD from cannibis extract available in the US

Answer 15

Epidolex (cannabidol), Lennox-Sataut syndrome and Dravet syndrome

Question 16

What is the endocannabinoid system (ECS)

Answer 16

An endogenous homeostatic system present in all vertebrates that plays an important role in the nervous system and influences multiple physiologic processes

Question 17

What are the three components of ECS

Answer 17

Receptors, endocannabinoids, regulatory enzymes

Question 18

What are the receptors of the ECS

Answer 18

Cannabinoid receptor-1 and cannabinoid receptor-2

Question 19

What are the endogenous cannabinoids

Answer 19

Anandamine/AEA and 2-AG

Question 20

What are the regulatory enzymes of the ECS

Answer 20

FAAH and MAGL

Question 21

What is the difference in Activity between CB1 receptors and CB2 receptors

Answer 21

CB1 receptors modulate the release of different neurotransmitters while CB2 generally inhibits immune cell activation and production of pro-inflammatory cytokines

Question 22

T/F: CB1 receptors are outside the CNS while CB2 receptors are inside the CNS

Answer 22

False: CB1 receptors are inside the CNS while CB2 is outside the CNS

Question 23

Why is the use of cannabis not associated with coma/respiratory depression

Answer 23

Lack of CB receptors in the brainstem

Question 24

Which receptor does THC more often bind to, CBD

Answer 24

CB1, It doesn’t bind either

Question 25

What type of signaling is done in ECS, how

Answer 25

Retrograde, POST-SYNAPTIC cells from variety of signals endocannabinoids are produced ON DEMAND where they are released by cells (NOT STORED IN VESICLES)

Question 26

T/F: Endocannabinoids made by the post-synaptic cell binds pre-synaptic G-coupled protiens resulting hyperpolarization and decrease neurotransmitter release

Answer 26

True

Question 27

Where does exogenous CBD work in the ESC, what are the consequences

Answer 27

Inhibits FAAH, More anadamide is available to act on CB receptors

Question 28

Why is cannabis with high CBD: THC ratio associated with fewer psychoacitve effects

Answer 28

CBD inhibits the degredation of endogenous cannabinoid (anadamide) and its prologened presence prevents THC from interactive with CB receptors, INHBITS FIST PASS METABOLISM of THC into 11-hydroxy-THC (stronger psychoactive properties)

Question 29

T/F: Hemp is a genetic variant of C. sativa bred to maximize fiber content and the THC concentration is less than 0.3%

Answer 29

True

Question 30

T/F: Cannabis can be recommended but no prescribed

Answer 30

True

Question 31

Why would smokable products have THCA and CBDA

Answer 31

These are needed to convert to THC and CBD when heated

Question 32

Which types of routes of cannabis are the fastest, duration

Answer 32

Smoke or vaped, 2 to 6 hours

Question 33

How long is the onset for oral routes of cannabis, peak duration, bioavailability tip, con

Answer 33

30-90 mins, 2-3 hours, 4-24 hours, 4-20% increase if eaten with fatty food/ Potent metabolite (11-hydroxy-THC)

Question 34

What cannabis use do to the heart

Answer 34

Increased cardiac workload, increase in catecholamines, and postural hypotension

Question 35

Why is oral consumption of THC more potent

Answer 35

First pass metabolism converts a significant portion of THC into 11-hydroxy THC that is not only longer lasting but also potentially more psychoactive

Question 36

Which route has a quick onset but also lasts long

Answer 36

Oro-mucosal (not good for cancer patient with no saliva)

Question 37

What enyzme does cannabis smoke induce

Answer 37

1A2

Question 38

What enzymes are substrates of THC, inhibit

Answer 38

2C19, 2C9, and 3A4/ 3A4

Question 39

What enzymes are substrates of CBD

Answer 39

2C19 and 3A4

Question 40

What enzymes are inhibited by CBD

Answer 40

2C19, 3A4, 2D6, 2C9

Question 41

What is there milited evidence for cannibis use benefits

Answer 41

Increasing appetite and decreasing weight loss associated with HIV/AIDS, improve MS spasticity, improving symptoms of terrests, improving anxiety sympomts, symptoms of PTSD

Question 42

What does cannabis not do

Answer 42

Improve dementia, improve glaucoma, depressive symptoms in chronic pain or MS