Week 1 Flashcards
What should you know about common drugs?
MoA, indications, side effects, important pharmacokinetics/dynamics and what you would tell patient
What factors affect bioavailability of drugs?
Molecular weight/ ionisation, absorption (gastric pH/health of GI tract), first pass metabolism
What is the apparent volume of distribution?
Volume in which the amount of drug would need to be uniformly distributed to produce observed blood concentration
What is the half life of a drug?
Time required for serum plasma concentration to decrease by half, determined by clearance and volume of distribution
What are linear pharmacokinetics?
- Concentration that results from a dose is proportional to the dose (double the dose, double the concentration)
- Rate of elimination is proportional to the concentration (50% of drug will be eliminated in a given time frame)
What are non-linear pharmacokinetics?
- Concentration that results is not proportional to dose
- Rate of elimination is constant regardless of amount of drug present
- Dosage increases can saturate binding sites and result in non-proportional increase in drug levels
- Due to saturation of enzymes that metabolise drugs
Does phenytoin have linear or non-linear pharmacokinetics?
Non-linear
What are drug receptors?
Macromolecular component of a cell with which a drug interacts to produce a response (usually proteins- regulatory, enzymes, transport or structural)
What are the types of drug receptor?
1 Enzyme linked (multiple actions) 2 Ion channel linked (speedy) 3 G protein linked (amplifier) 4 Nuclear (gene) linked (long lasting)
What is affinity?
Measure of propensity of a drug to bind receptor, the attractiveness of drug and receptor
What is the efficacy of a drug?
Ability of a bound drug to change the receptor in a way that produces an effect; some drugs possess affinity but not efficacy
What is potency of a drug?
- Relative position of the dose-effect curve along the dose axis
- Low potency is a disadvantage only if the dose is so large that it is awkward to administer
How is therapeutic index calculated?
Therapeutic dose or lethal dose for 50% of population (TD50 or LD50) divided by efficacious dose for 50% of the population (ED50)
What special patient populations should be considered when prescribing drugs?
Renal disease, hepatic disease and cystic fibrosis
What drugs should be prescribed differently in renal disease?
- Antibiotics: reduce dose
- Low molecular weight heparins: reduce dose
- Metformin: avoid
- NSAIDs: avoid
- Digoxin: reduce loading dose
- Phenytoin: reduce dose
- ACE Inhibitors: caution
How does hepatic impairment affect pharmacokinetics?
- First pass metabolism
- Activation of prodrugs
- Decreased protein binding
- Decreased elimination
How does hepatic impairment affect pharmacodynamics?
Altered drug effect
What are the clinical features of ADHD?
Clinical features must be apparent before the child is age 7 years, excessive for the child’s age and dev, pervasive (evident across more than 1 environments, normally 3), symptoms may worsen in the afternoon
What % is the brain of a child with ADHD smaller than their peers?
3%
What neurological factors affect/cause ADHD?
- Smaller brain volume
- Smaller basal ganglia
- Right dorso-lateral prefrontal lobe reduced
- Smaller cerebellar vermis
- Attentional systems involve anterior fronto-striatal network
- Posterior parieto-cerebellar circuits
What co-morbidities are associated with ADHD?
- sleep disorders
- behavioural difficulties
- specific learning disabilities
- development co-ordination disorders
- social communication difficulties
- anxiety symptoms
- tic disorders e.g tourette syndrome
- mood difficulties
How is ADHD assessed?
No specific diagnostic test, instead assessment includes:
- direct observations in more than 1 setting
- psychoeducational assessment
- structured questionnaires
- identifying co-morbid (mental) health problem
- developmental history
- develop a formulation
What is important to look for in a parental report?
- current behaviours, activity levels, impulsivity, emotional reactivity
- ability to sustain interest/attention (with/without adult involvement)
- eating and sleeping habits
- responses to and interactions with others
- parental management strategies
- structures questionnaires
What other features of a history are important to look at when diagnosing ADHD?
- pregnancy/delivery
- patterns of feeding, sleeping and play
- activity levels, impulsivity, emotional reactivity
- ability to sustain interest/attention
- is the developmental stage appropriate for the chronological age
