Week 1: Fluids and Electrolytes Flashcards
(56 cards)
Drug>
Chemicals introduced into the body to cause some sort of change.
Pharmacology
the study of the biological effects of chemicals
Chemical name
molecular structure
Generic name
shortened name based on the chemical name
Trade name
name which drug is sold by individual companies
Commonwealth legislation
therapeutic goods act (89), therapeutic goods regulation (90), national health act (53), narcotic drugs act 61)
State legislation
therapeutic good act (94), drugs poisons & controlled substances act/”” regulation (81/06)
Schedule 2
pharmacy only
Schedule 3
pharmacist
Schedule 4
prescription
Schedule 8
controlled drugs
Schedule 11
drugs of dependence
Absorption
drug moves from site of admission to blood stream to get to target site
Distribution
once in the blood stream, it can be distributed to various sites
Biotransformation (metabolism)
chemical alteration of the drug to water soluble metabolite
Factors affecting drug metabolism >
> genetic, environment, disease status, ageing process
Hepatic first pass
go through portal system and liver before entering systemic circulation
Plasma half life
time taken for the plasma concentration of a drug to fall by 50%
Factors contributing to ADR’s
Age, gender, dose, polypharmacy, history, genetics
Factors that influence medication across the lifespan
pregnancy, lactation, paedicatric, geriatric
Fluid body compartments
intracellular (2/3 TBW), Extracellular (1/3TBW) [interstitial, intravascular]
Crystalliods
body fluid composition & moves quickly between compartments
Colloids
contain undissolved solutes which are too large to pass through capillary wall, stays longer intravascular & draws fluid from interstitial ^ BP longer
Isotonic IV fluids
0.9% NaCl normal saline; fluid. Hartmanns solution; electrolytes. 5% dextrose in water; fluid and energy