week 11 pharmacology 1

Question 1

what is an agonist

Answer 1

molecules/compounds that bind to receptor

Question 2

what are the things that effect how the agonist works

Answer 2

shape and physio chemical properties

Question 3

what is antagonist

Answer 3

they do not activate the receptor

• prevents the agonist from binding (eg antihistamine)
• called competitive antagonist

Question 4

what are the the 4 families of receptors and speed of response

Answer 4

1. ligand-gated ion channels (quickest)
2. g-protein-coupled receptors (seconds)
3. kinase-linked receptors
4. nuclear receptors

Question 5

what is the process of nuclear receptors

Answer 5

1. the steroid hormone passes through the plasma membrane
2. binds to a receptor protein in the cytoplasm activating it
3. the hormone receptor protein complex enters the nucleus and binds to the specfic gene
4. the bound protein stimulates the transcription of mRNA
   5 mRNA is translated into a specific protein

Question 6

what is the agonist-receptor dependent on

Answer 6

concentration dependent

Question 7

what does Kd stand for and what does it mean

Answer 7

is the value that can be viewed as the concentration at which 50% of receptors are bound based on affinity and charge

Question 8

what happens if a Kd value is small

Answer 8

the greater the affinity the drug has for the receptor cite
meaning that the drug has a higher power in that tissue then other drugs meaning you only need a little amount to reach the 50% bound of receptors