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Flashcards in week 2 Deck (13):
1

Depth of anesthesia depends on [ ] of anesthetic in the brain. Rate of effective [ ] depends on what 5 things?

1. [ ] of anesthetic in the inspired air
2. alveolar ventilation rate
3. pulmonary blood flow (cardiac output)
4. Blood: gas partition coefficient
5. Potency (oil: gas partition)

2

Reaching steady-state anesthesia required 4 phases:?

Phase I: lung factors
Phase II: uptake of GA from alveoli to the blood
Phase III: uptake form arterial blood to body tissue (esp brain)
Phase IV: tissue distribution

3

Products of which metabolism are often adverse rxn to volatile anesthetics?

Hepatic

4

Anesthetic is equally soluble in blood and _____ , but are more soluble in ______.

lean tissue
fatty tissue

5

most widely used inhalation anesthetic

isofluorane
- more potent, less incident of hepatotoxicity
- less seizure propensity
- pungent - trigger cough

6

Sleep is a _____state, and the indiv. need for sleep is genetically determined

behavioral

7

Chronic jet lag and shift work →
sleep deprivation→ _____

hippocampal atrophy

8

____Nucleus conveys circadian info recieved from retina to sleep wake switch in the hypothalamus

superior collicus nucleus
- synchronizes sleep cycle with circadian rhythm

9

ventrolateral preoptic area (VLPO) inhibits arousal during ____ sleep, but active in ___

NREM
REM

10

REM sleep is driven by _____ and ______

pedunculo pontine )PPT)

Laterodorsal tegmental (LDT)

11

homeostatic system (process S) likely mediated by which NT?

Adenosine

12

Melatonin reduces ____ activity and arousal

superior colliculus nucleus

13

evolution of insomnia " 3 P's"

predisposed
precipitant
perpetuating factors

insomnia increase accident risk, wt, depression, HTN