Flashcards in week 2 Deck (13):
Depth of anesthesia depends on [ ] of anesthetic in the brain. Rate of effective [ ] depends on what 5 things?
1. [ ] of anesthetic in the inspired air
2. alveolar ventilation rate
3. pulmonary blood flow (cardiac output)
4. Blood: gas partition coefficient
5. Potency (oil: gas partition)
Reaching steady-state anesthesia required 4 phases:?
Phase I: lung factors
Phase II: uptake of GA from alveoli to the blood
Phase III: uptake form arterial blood to body tissue (esp brain)
Phase IV: tissue distribution
Products of which metabolism are often adverse rxn to volatile anesthetics?
Anesthetic is equally soluble in blood and _____ , but are more soluble in ______.
most widely used inhalation anesthetic
- more potent, less incident of hepatotoxicity
- less seizure propensity
- pungent - trigger cough
Sleep is a _____state, and the indiv. need for sleep is genetically determined
Chronic jet lag and shift work →
sleep deprivation→ _____
____Nucleus conveys circadian info recieved from retina to sleep wake switch in the hypothalamus
superior collicus nucleus
- synchronizes sleep cycle with circadian rhythm
ventrolateral preoptic area (VLPO) inhibits arousal during ____ sleep, but active in ___
REM sleep is driven by _____ and ______
pedunculo pontine )PPT)
Laterodorsal tegmental (LDT)
homeostatic system (process S) likely mediated by which NT?
Melatonin reduces ____ activity and arousal
superior colliculus nucleus