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Pharmacology Block 2 > Week 2 Drugs > Flashcards

Week 2 Drugs Flashcards

1
Q

Lysergic Acid Diethylamide

A

Serotonin Agonist
Full/partial agonist of 5-HT.2 R
LSD= hallucinogen

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2
Q

Buspirone

A

Serotonin Agonist
Partial agonist of 5-HT.1A R
(X) antianxiety

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3
Q

Sumatriptan

A 
Serotonin Agonist 
Agonist of 5HT.1D-R
-inhibit release of vasoactive peptides
-promote vasoCONSTRICTION
(X) migraine headaches
(-) nausea, vomiting, dizziness, angina, flushing 
(O) Recent MI
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4
Q

Fluoxetine

A

Indirect Serotonin Agonist
SSRI–/ reuptake of serotonin
(X) affective disorders: OCD and panic attacks
(-) sexual dysfunction, nausea

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5
Q

Phenelzine

A

MAOI—/ metab of serotonin, NE, and DA

X) depression
narcolepsy
(-) food induced hypertensive crisis (pyridines

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6
Q

Cyproheptadine

A

5HT.2-R Antagonist
(X) allergic skin reactions (pruritis, uticaria)
-Carcinoid

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7
Q

Ondansetron

A

5HT.3 R Antagonist

X) chemotherapy-induced nausea/vomit (GI and brain R

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8
Q

Alosetron

A

Selective 5HT.3 Antagonist
(X) women with diarrhea-predominant IBS
(-) severe GI side effects

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9
Q

Nitroglycerin

A

VasoDILATOR
^ cGMP>relax arterial/venous sm
(X) heart failure
(-) hypotension

venous dominant- reduced preload

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10
Q

Nitroprusside

A

VasoDILATOR
>*NO–> ^ cGMP> relax arterial/venous sm
(X) hypertensive emergency
(-) hypotension

arterial/venous; ^ SV (reduced pre and after load)

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11
Q

Hydralazine

A

VasoDILATOR_ direct (^cGMP)
(X) heart failure
(-) hypotension

arterial

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12
Q

Minoxidil

A

VasoDILATOR_direct “rogaine”(K+channel opener)
(X) Heart failure
HTN
(-) fluid retention

Arterial

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13
Q

Diazoxide

A

VasoDILATOR_ membrane channel dilator
K+ channel activator
(X) HTN emergency, hypoglycemia

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14
Q

Ca++Channel blockers

A

VasoDILATORs

  1. verapamil
  2. diltiazem
  3. nifedipine

-increase heart cntxn
- reduced sm cntxn
Arterial

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15
Q

Verapamil

A

VasoDILATOR_ Ca++ blocker

Phenylalkylamine

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16
Q

Diltiazem

A

VasoDILATOR_ Ca++ blocker

Benzothiazapine

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17
Q

Milrinone

A

VasoDILATOR_ PDE 3 inhib
^ cAMP^ heart cntxn, rlxn bv
(X) Heart failure

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18
Q

Inamrinone

A

VasoDILATOR_PDE 3 inhib
^cAMP^ heart cntxn, rlxn bv
(X) heart failure

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19
Q

Cilostazol

A

VasoDILATOR_PDE 3 inhib
^cAMP–> ^ heart cntxn, rlxn bv
(X) heart failure

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20
Q

Sildenafil

A

VasoDILATOR_ PDE 5 inhibitor
^cGMP–> rlxn bv
(X) erectile dysfunction

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21
Q

Tadalafil

A

VasoDILATOR_ PDE 5 inhibitor
^cGMP–> rlxn bv
(X) erectile dysfunction

22
Q

ACE Inhibitors

A

VasoDILATOR_ Angiotensin Converting Enzyme inhib

23
Q

Fenoldopam

A

VasoDILATOR_ D.A1 R agonist

(X) hypertensive crisis

24
Q

Prazosin

A

VasoDILATOR_ a-adrenergic blocker

(X) HTN

25
Albuterol
BronchoDILATOR_ B2 agonist
26
Pirbuterol
BronchoDILATOR_ B2 agonist
27
Terbutaline
BronchoDILATOR_ B2 agonist
28
Salmeterol
BronchoDILATOR_ B2 agonist
29
Formoterol
BronchoDILATOR_ B2 agonist
30
Ipratropium
BronchoDILATOR_ Anti-cholinergic
31
Tiotropium
BronchoDILATOR_ Anti-cholinergic
32
Theophylline
BronchoDILATOR_ methylxanthine
33
Aminophylline
BronchoDILATOR_ methylxanthine
34
Aliskiren
Renin inhibitor (blocks angiotensinogen> angiotensin I) (X) HTN (-) minimal side effects ~ placebo
35
Losartan
``` Angiotensin AT.1-R blocker (X) essential HTN Heart failure (-) dizziness, cough, angioedema (O) pregnancy ```
36
Captopril
``` ACE inhibitor (X) essential HTN Heart failure (-) rash, proteinuria, neutropenia, cough, angioedema hyperkalemia ```
37
Enalapril
``` ACE inhibitor_ prodrug (X) essential HTN Heart failure (-) rash, proteinuria, neutropenia, cough, angioedema hyperkalemia ```
38
Lisinopril
``` ACE inhibitor_ prodrug (X) essential HTN Heart failure (-) rash, proteinuria, neutropenia, cough, angioedema hyperkalemia ```
39
Spironolactone
Aldosterone inhibitor_ MC-R antagonist | (X) diuretic, HTN
40
Eplerenone
Aldosterone inhibitor_ MC-R antagonist | (X) diuretic, HTN
41
Propranolol
B- adrenergic blocker (1st gen) | ---/ renin release
42
Metoprolol
B-adrenergic blocker (1st gen) | ---/ renin release
43
Desmopressin
ANTI-diuretic intranasal (X) NEUROgenic diabetes insipidus (X) pre-op prophylactic for hemophilia (^ vonW factor and VIII)
44
Phenylalkylamines
Calcium Channel Blocker (CCB) | Verapamil
45
Benzothiazepines
Calcium Channel Blocker (CCB) | Diltiazem
46
1,4- Dihydropyridines
Calcium Channel Blocker (CCB) | Nifedipine, Amlodipine
47
Verapamil
Phenylalkylamine_ myocardial CCBs (-) heart block (O) hypotension, bradycardia, conduction defect, cardiac failure
48
Diltiazem
Benzothiazepines_myocardial CCBs (-) heart block (O) hypotension, bradycardia, conduction defects, cardiac failure
49
Nifedipine
1,4 dihydropyridine_ CCB
50
Amlodipine
1,4 dihydropyridine_ CCB

Pharmacology Block 2 (7 decks)

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