Week 3 Exam Flashcards
What method chemically hydrolyzes cholesterol esters to make all free cholesterol then uses the LB method
Abell reference method
What method reacts cholesterol with sulfuric acid and acetic anhydride to form a colored product
Liebermann-Burchard
What is the current method for cholesterol testing?
Enzymatic endpoint method uses cholesterol esterase to break ester linkage then cholesterol oxidase to produce hydrogen peroxide which causes and absorbance change
Which lipid is measured by precipitating any apolipoprotein B containing lipids, centrifuging, and analyzing the supernatant
HDL! The only lipid without apo-b
What lipid is measured by reacting it with lipase to produce glycerol and then enzymatically reacting that glycerol to produce a colored product?
Triglycerides
Five tests that may be used to assess risk for cardiovascular disease
CRP, myeloperoxidase, oxidized LDL, homocysteine, lpPLA2
What is the time frame for the appearance, peak, and return to normal for CK
3-8h
10-36h
3-4 days
What is the time frame for the appearance, peak, and return to normal for AST
6-8h
18-24h
4-5days
What is the time frame for the appearance, peak, and return to normal for LD
8-12h
24-48h
6 days
What is the time frame for the appearance, peak, and return to normal for myoglobin
.5-2h
5-12h
18-30h
What is the time frame for the appearance, peak, and return to normal for CKMB
1-4h
4-8h
24h
What is the time frame for the appearance, peak, and return to normal for troponin
4-6h
24h
5-15days
Increase in anion gap and metabolic acidosis occurs from ingestion of what substances?
Methanol and ethylene glycol
Which apolipoprotein is the receptor protein that allows LDL to bind to hepatic or extrahepatic cells to deliver it’s cholesterol load
B100
What apolipoprotein functions to cause secretion of triglyceride from the intestine?
b48 chylomicrons!
What are some causes of respiratory acidosis
Respiratory chemoreceptor depression like trauma, narcotics or neuromuscular system disorders or pneumothorax or multiple rib fractures
COPD asthma and pneumonia emphysema pulmonary fibrosis cardiac disease RDS in infants
What are causes of respiratory alkalosis
Anxiety, nervousness, excessive crying, pregnancy, mechanical respirators, CNS lesions, alcoholism, CHF, anemia
What are causes of metabolic acidosis
Ketoacidosis, lactic acid doses, poisonings, renal failure, renal tubular acidosis, increased renal excretion of bicarb, decreased renal absorption of bicarb, excessive loss of duodenal fluid through diarrhea
Causes of metabolic alkalosis
Excessive bicarb administration, multiple blood transfusions, antacids, prolonged vomiting, nasogastric suctioning, diuretic therapy, hyperaldosteronism
Phenobarbital
Anticonvulsants
Phenytoin
Anticonvulsant
Primidone
Anticonvulsant
Carbamazepine
Anticonvulsant
Ethosuximide
Anticonvulsant
