Week 3- HT/Pit/End Organ Axes Flashcards
(17 cards)
Hypokalemia, hypercalcemia and lithium are associated with…
nephrogenic DI
Is galactorrhea associated with low testosterone?
No- must also have high prolactin or estrogen
What is the most useful screen for hemachromatosis?
transferrin saturation
What is the heterozygote prevalence for HFE? What are the most common joints affected by hemachromatosis?
1/10
2nd and 3rd MCPs
What is the most common cause of isolated pituitary-gonadal axis failure in young men?
hemochromatosis
What is the most important test for suspected growth acceleration or deficiency due to GH
IGF-1 levels
Is BMD correlated to testosterone levels
yes, but through its conversion to estradiol
Does decreased testosterone lead to increased or decreased abdominal adiposity?
increased
What is the expected serum osmolality in DI?
high because you are unable to reabsorb water so you’re essentially concentrating your serum
What does FSH and LH do in men
LH: make TT in Leydig cells
FSH: sperm maturation
What is the usual initial presentation of hypogonadism?
low energy and low libido, progressing to loss of sexual hari, muscle mass, BMD,
What things negatively feedback in the pituitary-gonadal axis
estradiol inhibits just FSH
inhibin is from sertoli cells and blocks FSH secretion at the HT and the ant. pit.
Is primary or secondary hypogonadism more likely to have gynecomastia?
primary. primary is in the testes.
What hormones suppress gonadotropin release
- prolactin
- cortisol
- androgens, estrogens, progestins
What is the result of a triple bolus test?
give: insulin, TRH, GnRH
Insulin induces hypoglycemia (GH increase, Cortisol increase)
TRH induces TSH and prolactin
GnRH induces FSH and LH
What is the axis for growth hormone?
What are the stim/suppression tests
