Week 4: Endocrine Balance Flashcards

1
Q

Islets of Langerhans

A

where insulin is produced in the pancreas

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2
Q

blood glucose homeostasis

A

Normal Eating > secrete insulin > glucose moves from blood into cells (muscle, liver adipose)

Normal Fasting > basal insulin release AND/OR when BG low glucagon is released > liver secretes glucose

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3
Q

what is diabetes?

A

insulin excretion/use is disrupted, glucose isn’t broken down into useable states

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4
Q

types of diabetes

A

type 1
type 2
gestational
diabetes associated with conditions and syndromes

pancreas issues or corticosteroids

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5
Q

Type 1 diabetes

A

complete lack of insulin

autoimmune condition or genetics

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6
Q

S&S of Type 1 diabetes prior to diagnosis

A

Polyuria, polydipsia, polyphagia & weight loss

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7
Q

complication in type 1 diabetes

A

hyperglycemia- Diabetic keto acidosis
hypoglycemia

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8
Q

Type 2 diabetes

A

insulin resistance

risks: Metabolic Syndrome (hypertension, obesity, hyperglycemia, high LDLs and low HDLs)

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9
Q

medications for diabetes

A

type 1: insulin dependent for life
type 2: oral antihyperglycemic agents or insulin

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10
Q

symptoms of diabetes

A

Result of: hyperglycemia, glucose excreted by kidneys, fluid/protein follow by osmosis = fluid volume deficit

neuro-cognitive (dizziness, confusion), weight, polydipsia, hungry, polyuria

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11
Q

complications of diabetes

A

Atherosclerosis (glucose damages blood vessels)
Poor perfusion
Damage to many body systems (ocular, cardiac, renal, integumentary, vascular, immune)

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12
Q

ocular complications

A

damage to micro-vessels in eye = blindness, blurred vision

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13
Q

cardiac complications

A

atherosclerosis = increased risk or MI, coronary artery disease, stroke, hypertension

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14
Q

renal complications

A

Damage to nephrons =increased risk of CKD

Neuropathy in bladder
=neurogenic bladder, UTI

50% of people with kidney disorders have a diabetes diagnosis – the kidneys are exposed to increased glucose

Neurogenic bladder – the nervous system that tells you to urinate can become unresponsive

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15
Q

vascular complications

A

Peripheral Vascular Disease
Peripheral Neuropathy =poor wound healing, numbness in feet/hands, falls risk, mobility

**foot ulcers

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16
Q

immune system complication

A

Impaired perfusion limits ability for immune cells to reach sites of
infection

High blood glucose is a breeding ground for infection

Decreased neutrophil synthesis

Risk for septic shock (compensatory = normal BP, tachycardia,
tachypnea, pale skin)

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17
Q

integumentary complications

A

impaired wound healing
impaired immunity

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18
Q

HBA1C

A

Hemoglobin A1c
Amount of glucose attached to Hb (glycated hemoglobin)

Reflects the average serum glucose level over the previous 2 to 3 months

higher the HBA1C = poorer control of diabetes

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19
Q

Causes of hypoglycemia

A

Too much insulin or oral antihyperglycemic agents

Inadequate food intake

Excessive physical activity

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20
Q

Hypoglycemia

A

Development of autonomic & neuroglycopenic symptoms

Low plasma glucose (< 4.0 mmol/L)

Symptoms that respond to CHO administration

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21
Q

S&S hypoglycemia (most common)

A

Autonomic (neurogenic): Trembling
Sweating
Anxiety
Nausea

Neuroglycopenic:
Poor concentration
Confusion (ofen first sign in older adults)

22
Q

hypoglycemia - mild

A

autonomic symptoms, able to self-treat

23
Q

hypoglycemia - moderate

A

autonomic & neuroglycopenic, able to self-treat

24
Q

hypoglycemia - severe

A

autonomic & neuroglycopenic, BG under 2.8, requires support,
unconsciousness may occur

25
Q

hypoglycemia treatment - mild/moderate

A

Treat and then notify provider

Mild – Moderate:
Oral ingestion of 15 g carbohydrate
Glucose or sucrose tablets/solution (preferable) OR juice (~ 175 mL)

Retest BG in 15 minutes and monitor closely

Re-treat with another 15 g carbohydrate if the BG level remains <4.0 mmol/L, according to protocol

26
Q

hypoglycemia treatment: severe conscious

A

Severe (Conscious):

Oral ingestion of 20 g carbohydrate
Glucose or sucrose tablets/solution (preferable) OR juice (~ 250 mL)

Retest BG in 15 minutes and monitor closely

Re-treat with if the BG level remains <4.0 mmol/L, according to protocol

27
Q

hypoglycemia treatment: severe unconscious

A

Severe (Unconscious):
IV Access

IV Push 20–50 mL of D50W over 1 – 3 minutes

No IV Access
SC/IM Glugagon 1 mg

**If the patient is not permitted to eat anything – going to go the IV access route

28
Q

hypoglycemia recovery

A

BG rises above 4.0
Monitor closely (maintaining proper BG levels)

When in hypoglycemia, the body releases adrenaline, which
causes the rapid uptake of K into cells

Eat usual meal/additional snack

Find the underlying factor

29
Q

hypoglycemia electrolytes

A

Hypoglycemia has close relationship with hypokalemia: when in hypo body releases adrenaline, adrenaline causes rapid uptake of K into cells

30
Q

causes of Hyperglycemia

A

T1D - not enough insulin
T2D - lack of effective stimulation (insulin resistance)

31
Q

diabetic hyperglycemia emergency

A

type 1 - BG greater (>) than 13.9 mmol/ L = diabetic keto acidosis

type 2 - BG greater (>) than 33 mmol/L = hyperglycemis hyperosmolar syndrome

32
Q

S&S Hyperglycemia

A

Early Signs: tiredness, polurea, dehydration, polydipsia

33
Q

health teachings for diabetes

A
  • T1D – insulin administration
  • T2D – diet

Diabetic diet
Avoid low simple sugar (pop, juice, candy, white bread, white rice, pasta, French fries)

Include healthy fats (peanut butter, whole milk), high fiber CHOs (beans, brown bread, whole grains), eat a bedtime snack

  • Medication regimen
  • BG monitoring
  • Adjusting regimen
  • Sick day management
34
Q

pharmacological treatments

A
  • insulin, insulin subcut, insulin pump, oral meds
  • rapid (aspart, lispro, humalog), short acting (toronto, novolin), intermediate, long acting, imsulin pump, oral meds

Type 2 starts with oral medications – if doesn’t work then they will supplement with insulin

Type 2 diabetics cells are resistant to insulin – so their doses will be far different because they need more insulin to try and get a response

35
Q

Insulin basics: administration

A

Check BG prior to administration
BG < 4.0 then give CHO

Administer based on Sliding Scale

Food should be given during the peak of the insulin

Do not mix long acting and other types of insulin

Draw up Regular insulin (clear) first and then NPH insulin (cloudy)

S/C Injections

36
Q

Rapid (Aspart, Lispro, Humalog)

A

Onset: 15 minutes, peak = 30-90 minutes

Duration: 3-4 hours

Indication: rapid BG decrease (postprandial, hyperglycemia)

37
Q

Short acting (Regular) (Toronto, Novolin R)

A

only insulin that can be given through IV*

Onset: 2-3 hours

Duration: 4-6 hours

Indication: 20-30 minutes before meal

38
Q

Intermediate (NPH, Humulin N, Novolin N)

A

Peak: 4-12 hours

Duration: 16-20 hours

Indication: post meal

39
Q

Long acting (Detemir, Glargine (Lantis)

A

Peak: NO PEAK

Duration: Over 24 hours

Indication: basal dose (do not mix)

40
Q

Insulin Pump

A

Insulin is delivered continuously and in customized doses of rapid-acting insulin 24 hours a day

41
Q

Oral medications (antihyperglycemics)

A

ONLY for T2D

Try diet and exercise first

AVOID: Iron, Ca and things that contain Ca, like antacids and dietary sources high in Ca.  impaired absorption

42
Q

Metformin

A

Pharmacologic class: Biquanides

Action: treat hyperglycemia, lower BG

Side effects: stomach pain, GI upset, gas, bloating, NVD, constipation
(may subside within a few weeks)

Nursing considerations:
Monitor BG (risk of hypoglycemia)
Potentially hepatotoxic

Do not give in eGFR under 30 (poor kidney function, cleared by
the kidneys)

Hold before contrast dye

43
Q

Glyburide

A

Action: treat hyperglycemia, lower BG

Side effects: GI upset, skin reactions (use sunscreen), weight gain

Cautions: for heart failure/MI history

Nursing considerations:
Monitor BG (hypoglycemia)
Avoid alcohol (increases risk of hypoglycemia)

44
Q

Rosiglitazone (Avandia), Pioglitazone

A

Action: treat hyperglycemia, lower BG

Side effects: weight gain, edema, macular edema, heart failure

Caution: for heart failure/MI history

Nursing considerations:
Monitor BG (HIGH risk of hypoglycemia)
Hepatotoxic (monitor ALT and AST)

Associated with increased risk of bladder cancer of genetic origin

45
Q

Acarbose

A

Action: treat hyperglycemia, lower BG

Side effects: gas, diarrhea, bloating, stomach pain, GI upset, NV

Caution: for heart failure/MI history

Nursing considerations:
Monitor BG (risk of hypoglycemia)
Avoid in clients with GI issues (ie. IBS, Chrohn’s)

46
Q

Sliding Scale

A

Combine insulins of different durations e.g. short + long acting

Goal: mimic the normal insulin secretion pattern
i.e. increases with food

Sliding Scales:
- Approximate dailyinsulinrequirements

  • Progressive increase in AC meal or HSinsulindose
  • Based on predefined blood glucose ranges
  • Client administered dose based on

BG level
RISK = HYPOglycemia

47
Q

Key points for Subcutaneous Insulin Administration

A

Check BG prior to administration
Under 4.0 = give CHO

Administer based on sliding scale

Food should be given during the
peak of insulin

Do not mix long acting and other types of insulin (do not have a peak)

Draw up regular insulin (clear) first, and then NPH insulin (cloudy)

48
Q

Hypothyroidism

A

too little hormone
LOW & SLOW

o Cold intolerance
o Decreased sweating
o Weight gain
o Constipation
o Depression and irritability o Irregular and heavy periods o Slow heart rate
o Brittle nail
o Muscle/jointpain
o Puffyface

49
Q

Hyperthyroidism

A

too much hormone

HIGH & HOT

o Weight loss or gain
o Short and light periods
o Increased sweating
o Nail thickening and flaking o Puffy/bulging eyes
o Heatintolerance
o Nervousness and anxiety o Racing heart
o Muscle weakness
o Diarrhea

50
Q

Levothyroxine (Synthroid)

A

Hypothyroidism medication

Side effects: fever/hot flashes, sweating, nervousness, irritability, NVD, headache,
insomnia

o Nursing considerations:
 Monitor toxicity
 Risk of hyperthyroidism
 Tachycardia, chest pain, palpations
 Take in morning without food
 Avoid calcium and iron – impacts absorption
 Avoid fluctuations in thyroid levels

51
Q

Iodine

A

Hyperthyroidism medication

acts to destroy thyroid hormone in the body

52
Q
A