Week 5- overview of Epilepsy Flashcards
what is epilepsy?
-is a neurological condition affecting the brain.
what is the definition of epilepsy from ILAE?
as a disease of the brain
• At least 2 unprovoked (or reflex) seizures occurring more than 24hours apart
• One unprovoked (or reflex) seizure and a probability of further seizures
similar to the general recurrence risk after 2 unprovoked seizures (at least
60%) over the next 10years; or
• Diagnosis of epilepsy syndrome”(1)
what is a seizure?
the transient occurrence of signs or
symptoms due to abnormal excessive or synchronous neuronal
activity in the brain
what is the incidences and prevalence for epilepsy?
- affects over 70 million people worldwide.
- Close to 80% of those with epilepsy live in low- to middle income countries(3,4)
what percentage of people with epilepsy aren’t receiving the right treatment~?
75%
who can epilepsy affect?
can affect people of all ages, race, and gender
• Highest in infants and people over 50
-People who have learning difficulties also have higher rates of epilepsy in
comparison to the general population
what is the mortality for people with epilepsy? what causes deaths??
• There is an increased risk of premature death in patients with epilepsy
-caused by conditon itself=injury, during seisure, The antiepileptic treatment, status epilepticus, co-morbities
- SUDEP – sudden unexpected death in
epilepsy
what how does SUDEP occur?
- can occur just after a seizure not all the time
- can be related to charges in heart rhythm
- can occur in their sleep or at night so can go unseen
- risk factors of SUDEP= no treatment, night seizures
what is the aetiology of epilespsy?
-not always known
-2/3 of people hae epilespy that has an unknown cause
• Structural= stroke, trauma
• Genetic= mutation
• Infectious= known infection
• Metabolic= metabolic disorder
• Immune= inflammation
what are some risk factors of epilepsy?
- Premature birth
- Complicated febrile seizures (seizures brought on by a high temperature)
- Brain development malformation
- A family history of epilepsy or neurological disease
- Head trauma
- Infections (e.g. meningitis and encephalitis)
- Tumours
- Cerebrovascular disease/stroke
- Dementia and neurodegenerative disorders (Alzheimer’s disease)
- Drugs and alcohol withdrawal
how is epilepsy diagnosed?
• Referral to a specialist in epilepsy (3)
• Detailed history from the patient and eyewitness of the attack
-investigations
• EEG
• Blood tests
• Neuroimagine (MRI/CT)
• ECG
• U&Es
• Neuropsychological assessment= to help with learn difficulties identification
what are the different factors that are used to classify epilepsy’s?
- Seizure type
- Epilepsy type
- Epileptic syndrome
what are the main 3 groups seizures that can be classified?
- Focal seizures
- Generalised seizures
- Unknown
what are focal seizures?
• Increased neuronal activity originating and remaining in one
hemisphere of the brain.
-they are subdivide into:
• Simple focal seizures (no loss of consiousness)
• Complex or focal dyscognitive seizures (impaired awareness)
-motor symptoms or not
what affects the signs and symptoms of a seizure?
the specific area of
the brain involved
what are focal to bilateral clonic seizures?
they dont stay in one place in the brain branch off
what are generalised seizures?
• Increased neuronal activity that is widespread across both
hemispheres of the brain. These are subdivided into:
• Motor symptoms
• Non-motor symptoms
- NOTE – level of awareness is not looked at as much with this type of
seizure because the majority (not all) of these seizures the patient has
impaired awareness
when talking about motor symptoms what does tonic mean?
Sustained increased muscle contraction (tense and rigid muscles)
when talking about motor symptoms what does myclonus mean?
Muscle twitching (can involve single or multiple muscle groups)
when talking about motor symptoms what does atonic mean?
Muscles becoming limp (opposite to tonic)
when talking about motor symptoms what does clonic mean?
Jerking rhythmic twitching movements
when talking about motor symptoms what does tonic-clonic mean?
Where the seizure starts off in tonic phase (muscle rigidity, loss of consciousness,
respiration stops, involuntary crying) into clonic phase where you have muscle
twitching – relaxing and contracting, with loss of control of bladder and/or
bowels). After the seizure, some people get a post-ictal phase where they have
trouble remembering what has happened, feel tired, and confused.
when talking about non motor symptoms what does absence mean?
Vacant staring, movement stops
how is the epilepsy type similar to the seizure type?
it mirrors the type of seizure