Week 6: ADHD Flashcards

(36 cards)

1
Q

Attention in psychology

A
  • A mechanism for information selection
    • We receive too much information at the time
    • Helps us select the information we need now so that it can be further processed
    • Helps us navigate the world
  • Shapes our entire experience
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2
Q

Attention: limited resources

A
  • Our cognitive resources are limited, and we cannot process all the information at the same time
    • We need to be selective, and attention is our gatekeeper/ guides the processing of information
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3
Q

Types of attention (3)

A

Selective, sustained, divided

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4
Q

Selective attention

A

when focusing on one source of info, but ignoring/ suppressing others

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5
Q

Sustained attention

A

when focusing on the task (may not be exciting but takes a long time)

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6
Q

divided attention

A

when we try focus on 2 tasks at one time

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7
Q

General selective attention struggle

A
  • Filter the information so that an individual can focus on the task
    • … while still allowing behaviourally important stimuli to get through the filter
      Corbetta and Shulman (2002)
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8
Q

ADHD Overview

A

Persistent pattern of inattention and / or
hyperactivity-impulsivity that interferes with or
reduces the quality of functioning in daily life
Asherson et al. (2022)

		* The most diagnosed childhood psychiatric disorder
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9
Q

Heterogeneity of clinical profiles (doesn’t look the same for everyone)

A
  • Preschoolers: motor restlessness, aggressive and disruptive behaviours
    • Adolescents and adults: disorganized, impulsive and inattentive symptoms
      • Hyperactive symptoms – decrease with age
      • Inattention – remain
      • Females – mostly inattentive
        Luo et al. (2019)
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10
Q

ADHD in DSM-5 (3 types)

A

– Inattentive ADHD

	– Hyperactive-impulsive ADHD

– Combined

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11
Q

Inattention

A
  • Often fails to give close attention to details or makes careless mistakes in schoolwork, at work, or with other activities.
    • Often has trouble holding attention on tasks or play activities.
    • Often does not seem to listen when spoken to directly.
    • Often does not follow through on instructions and fails to finish schoolwork, chores, or duties in the workplace (e.g., loses focus, side-tracked).
    • Often has trouble organizing tasks and activities.
    • Often avoids, dislikes, or is reluctant to do tasks that require mental effort over a long period of time (such as schoolwork or homework).
    • Often loses things necessary for tasks and activities (e.g. school materials, pencils, books, tools, wallets, keys, paperwork, eyeglasses, mobile telephones).
    • Is often easily distracted
  • Is often forgetful in daily activities.
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12
Q

Hyperactivity and impulsivity

A
  • Often fidgets with or taps hands or feet, or squirms in seat.
    • Often leaves seat in situations when remaining seated is expected.
    • Often runs about or climbs in situations where it is not appropriate (adolescents or adults may be limited to feeling restless).
    • Often unable to play or take part in leisure activities quietly.
    • Is often “on the go” acting as if “driven by a motor”.
    • Often talks excessively.
    • Often blurts out an answer before a question has been completed.
    • Often has trouble waiting their turn.
    • Often interrupts or intrudes on others (e.g., butts into conversations or
      games)
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13
Q

DSM-5 Diagnostic Criteria: Innatentional

A

Six or more symptoms of inattention for children
up to age 16 years, or five or more for adolescents age 17
years and older and adults; symptoms of inattention have
been present for at least 6 months, and they are inappropriate
for developmental level

In addition, the following conditions must be met:
* Several inattentive or hyperactive-impulsive symptoms were present
before age 12 years.
* Several symptoms are present in two or more settings, (such as at
home, school or work; with friends or relatives; in other activities).
* There is clear evidence that the symptoms interfere with, or reduce
the quality of, social, school, or work functioning.
* The symptoms are not better explained by another mental disorder
(such as a mood disorder, anxiety disorder, dissociative disorder, or
a personality disorder). The symptoms do not happen only during
the course of schizophrenia or another psychotic disorder.

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14
Q

DSM-5 Diagnostic Criteria: Hyperactivity and Impulsivity

A

Six or more symptoms of
hyperactivity-impulsivity for children up to age 16 years, or
five or more for adolescents age 17 years and older and
adults; symptoms of hyperactivity-impulsivity have been
present for at least 6 months to an extent that is disruptive
and inappropriate for the person’s developmental level

In addition, the following conditions must be met:
* Several inattentive or hyperactive-impulsive symptoms were present
before age 12 years.
* Several symptoms are present in two or more settings, (such as at
home, school or work; with friends or relatives; in other activities).
* There is clear evidence that the symptoms interfere with, or reduce
the quality of, social, school, or work functioning.
* The symptoms are not better explained by another mental disorder
(such as a mood disorder, anxiety disorder, dissociative disorder, or
a personality disorder). The symptoms do not happen only during
the course of schizophrenia or another psychotic disorder.

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15
Q

three kinds (presentations) of ADHD can occur according DSM-5

A
  • Combined Presentation: if enough symptoms of both criteria
    inattention and hyperactivity-impulsivity were present for the past 6
    months
    • Predominantly Inattentive Presentation: if enough symptoms of
      inattention, but not hyperactivity-impulsivity, were present for the
      past six months
    • Predominantly Hyperactive-Impulsive Presentation: if enough
      symptoms of hyperactivity-impulsivity, but not inattention, were
      present for the past six months.
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16
Q

COMORBIDITIES

A
  • Initial interest in “isolated deficits” so comorbidities were seen “problematic”
    • Different estimates across studies
    • Depending on diagnostic criteria
    • Higher rates in referred samples than in population studies– Clinician’s illusion
      – Multiple deficits increase the chance of referral
      Van Bergen et al. (2023)
17
Q

Van Bergen et al. 2023 findings on comorbidity

A

About 1 in 4 children with diagnosed with one of these conditions may have more than one.

Children with dyslexia = 3x more likely to have dyscalculia (compared to those without)

Children with ADHD = 2x more likely to have dyscalculia

  • likely caused by shared genetic risk factors (rather than causal mechanism) = conditions should be tackled separately and genetic origins doesn’t meant interventions will not work.

(Over 77% of children with a disorder only have 1)

18
Q

Other Comorbidities, Drechsler et al. (2020)

A
  • Autism spectrum disorder 70-85%
    • Developmental coordination disorder 30-50%
  • Depression and anxiety disorders: 0-45%
19
Q

RISK FACTORS: Heritability

A

Heritability 0.7-0.8
– Higher than for personality, temperament, depression
– Similar to: schizophrenia, bipolar disorder, autism spectrum disorder
– Several gene candidates identified

20
Q

Risk factors: Environmental

A

– Prenatal maternal distress
– Pre-term birth / low birth weight (lecture 2)
– Social disadvantage and adversity
– Lead exposure
Nigg et al. (2020)

21
Q

Prevalence estimates

A
  • 8-12% children worldwide (Luo et al., 2019)
    • 5-7% children worldwide (Asherson et al., 2022)
    • 3-4% children worldwide (Nigg et al., 2020)
    • 5% children and 2.5% adults worldwide (Pievsky & McGrath, 2018)
22
Q

ADHD - dimensional

A
  • Should be seen as a continuum
    • Core symptoms and comorbid features are dimensionally distributed in the population
    • Clinically referred children with subthreshold ADHD symptoms – similar amount of functional deficits and
      comorbid symptoms but tend to: (a) come from higher social class families, (b) experience fewer family conflicts, (c) experienced fewer perinatal complications, (d) are older, (e) are more often female
      Drechsler et al. (2020)
23
Q

Gender differences

A
  • Boys / men more likely to be diagnosed than girls/ women
    • Females more likely to be diagnosed with predominantly inattentive form
      Luo et al. (2019)
    • Representative survey from Denmark (1995-2010) shows:
      – Decrease in the gender ratio from 7.5:1 to 3:1 at early school and from 8.1:1 to 1.6:1 in adolescentsDrechsler et al. (2020) - getting more equal in increasing age
24
Q

What happens to children with ADHD diagnosis when they grow up?

A
  • 15% of individuals diagnosed with ADHD as
    children continue to meet full criteria at age 25,
    though 65% are in partial remission (Pievsky &
    McGrath, 2018)
    • Other studies suggest persistence rates of 50-80% (Asherson et al., 2022)
25
Negative outcomes in adulthood
* 50-300% increased risk for serious secondary mental health problems: – Substance use disorders – Depression – Psychosis – Anxiety disorders * Increased chance of disastrous life outcomes: – School and occupational failure / underachievement – Poor health – Homelessness – Unemployment – Injuries / accidents – Suicide – Substance abuse – Crime * Among the most substantial direct and indirect drivers of premature death worldwide Asherson et al. (2022), Nigg et al. (2020) (notably these are relative risks - most poeple with adhd live happy lives - Nigg 2020
26
Side note on relative risks
* All this sounds scary, but it refers to relative risk * In our case, it means an increase of risk compared to a person without ADHD * Does a 50% increase in relative risk of going to prison mean that a person with ADHD will necessarily end up in prison? * What is the actual risk? – In the UK the average lifetime risk of imprisonment is about 7.3% (i.e., 1 in 14 people). – This means a 1.5x increase in baseline risk, not a 50 percentage point increase – We take the baseline risk (7.3%) and we multiply it by increase in relative risk (i.e., 1.5), and we see that the risk for a person with ADHD is 10.95% – This means that 89 out of 100 individuals with ADHD will not end up in prison * While this increased risk is important for policy-making and prevention, it is crucial to recognize that the majority of individuals with ADHD will not be imprisoned. * Same holds true for other relative risk statistics
27
ADHD in higher education
* May be related to negative educational outcomes * Often treated similarly to specific learning difficulties, so extra support can be provided * UK: Specific Learning Difficulties Assessment Standard Committee (SASC) recommend enabling provisional (‘nonmedical’) diagnosis of ADHD by trained psychologists / teachers to allow the students access the support in a timely fashion – Help with structure and planning – Training in robust coping skills Asherson et al. (2022)
28
COGNITIVE MECHANISMS: Barkley (1997) model
* Main problem in ADHD is response inhibition (also called behavioural inhibition) – The ability to inhibit an automatic response, or a response likely to result in immediate reinforcement (a “pre-potent response”) – Ability to delay a response or pause a response that has already been initiated – Ability to remain focused on the response in question and not be distracted by competing stimuli (”interference control”) * Impairment in response inhibition disrupts four executive processes: – Working memory – Self-regulation (ability to control one’s emotions, motivation, arousal to achieve goals) – Internalization of speech (one’s internal monologue which allows complex reasoning and reflection) * These lead to problems executing complex actions and goal-directed behaviours, specifically: motor control, fluency and syntax
29
Cognitive mechanisms – Default mode network theory
* Default mode network is a system in the brain, which activates when we “do nothing” * When we need to do a cognitive task, this network needs to be suppressed, and the circuits responsible for active cognitive processing kick-in * In this theory ADHD is caused by a difficulty in switching between the two (Songua-Barke & Castellanos, 2007) – This may explain larger RT variability among ADHD individuals
30
Reaction Time variability in individuals with ADHD
* One of the strongest cognitive correlates of ADHD * Larger variability occurs across different cognitive tasks * Related to some very long reaction times – Attributed to lapses in attention – These lapses might not be large enough to lead to error /missing to respond Tamm et al. (2012)
31
Cognitive correlates and what this suggests (Pievsky & McGrath 2018)
- Differences in cognitive mechanisms are usually a bit smaller than differences in the actual observable beh in real life This means cognitive mechanisms are not enough to explain ADHD as there's not as big as differences in day to day behaviour
32
Response inhibition – Stop-signal task
* Training in a simple binary classification * When hearing beep (or other visual signal) – refrain from responding
33
Treatment
* Most efficient: Medication + Psychoeducation * Psychological treatments – mostly tackling comorbid conditions * Cognitive Behaviour Therapy (CBT): enhancing positive behaviours and creating situations, in which such behaviours may occur * CBT + medication more efficient than medication alone * Cognitive trainings alone have limited impact Asherson et al. (2022), Drechsler et al. (2020)
34
Medications
* Should be initiated by health care professional * Important to adjust dosing to specific patient circumstances * Popular medications: – Methylphenidate – most common – Lisdexamfetamine – most common – Atomoxetine – Guanfacine Drechsler et al. (2020)
35
Psychoeducation Drechsler et al. (2020)
* Very important * Should include not only the patient but also their caregivers and school * Coping strategies: self-management, social skills, dealing with stigma * Planning should include the patient and their caregivers / closest family
36
Environmental interventions
* Conditions in the classroom to minimize distraction * Instruction of the teacher so that they use more appropriate teaching methods or promoting peer tutoring Drechsler et al. (2020)