Weken ontwikkeling Flashcards
1
Q
Week 4
A
- Urogenital ridge, gonads from mesonephros
- SRY & SOX9 expression in XY gonads in pre-Setoli cells switch on testicular development
2
Q
Week 5
A
Primordial germ cells migrate to urogenital ridge: gonocytes
3
Q
Week 6
A
Gonads lose bipotential
4
Q
Week 7
A
Foetal Leydig cells secrete testosterone, Sertoli cells secrete AMH
5
Q
Week 8-12
A
DHT in androgen-sensitive tissues act on the AR for masculanisation of external genitalia
6
Q
Week > 12
A
Foetal Leydig cells secrete INSL3, initiating testicular descent
