White Muscle Disease (WMD) Case Study Flashcards
what is the cause of WMD
dietary deficiency of vit E or selenium
what kind of myopathy is white muscle disease
nutritional myopathy
what is the effects of WMD
oxidant damage to cell membranes/proteins–>loss of cellular integrity–>muscle degeneration
what kind of muscle does WMD affect
cardiac and skeletal
what age of animal is WMD most common in
young and growing
what are the sources of WMD
vit E/ selenium deficiency in soil and poor quality hay, straw, root crops (not preserved in storage of forage)
do dams consume enough vit E/ selenium during gestation
yes
what regions of US is WMD most common in
Northeastern and Northwest
What are the clinical signs of WMD
muscle weakness/stiffness, difficulty rising, firms muscles on palpation, dysphagia, respiratory distress, cardia arrythmias, death
how quickly will death occur
<24 hrs despite therapy
how do you diagnose WMD
bloodwork, necropsy, histology
is the clinical course short or fast
short
what do you look for in bloodwork for WMD
increased creatinine kinase (CK), increased aspartate aminotransferase (AST), increased enzyme lactate dehydrogenase (LDH), low whole blood selenium or liver content, low vit E in plasma
what is the definitive thing in blood work for WMD
low whole blood selenium or liver content
what can be found in histology of muscle fibers
hypercontracted/fragmented, mineralized, macrophage infiltration
