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Gastrointestinal > Whitt: Gi viruses > Flashcards

Whitt: Gi viruses Flashcards

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1
Q

“most important agent of severe Diarrheal illness in infants and young children worldwide”

A

Rotovirus-(reoviridae)

followed by ETEC, UNKNOWN, Adenovirus

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2
Q

reoviridae stands for

A

respiratory
enteric
orphan

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3
Q

NON-ENVELOPED particles

2-3 concentric icosahedral capsids

A

rotavirus

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4
Q

rotavirus characters

A

non enveloped

2-3 concentric icosahedral capsids

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5
Q

rotavirus G

A

VP7-neutralization antigen

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6
Q

rotavirus P

A

VP4-neutralization antigen

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7
Q

rotavirus: only 4 G-P combos cause 90% of the Dz

* basis of the success of the vaccine

A

G1-P8
G2-P4
G3-P8
G4-P8

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8
Q

replication cycle of rotorviruses

A
  1. taken up by endocytosis (capsid prots are processed either in the gut or in the lysosome)-forms infectious subviral particle
  2. core enzymes-begin synthesizing mRNAs-asymettric only 10-12 +strands
  3. capped + strands to “assortment complexes
  4. negative strands made
  5. dsRNA genome complete
  6. lysis and release
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9
Q

asembly of rotoviruses occurs entirely within the

A

cytoplasm in cytoplasmic viroplasms (viral factory)

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10
Q

calciviridae

A

noroviruses

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11
Q

foodborne epidemic acute gastroenteritis in older children and adults

A

noroviruses (calciviridae)

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12
Q

non-enveloped, non-segmented

+ strand RNA virus

A

Norovirus

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13
Q

“hospitalized with D in first 2 years of life”

A

rotovirus

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14
Q

community based outbreaks in older school aged children and adults-non bacterial D

A

norovirus

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15
Q

winter vomiting disease

A

norovirus

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16
Q

transmission of roto-noro viruses

A

fecal oral mainly

*extremely stable in the environment

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17
Q

this bug outbreaks are located to a single source
1. contaminated food
(icing, oysters, salads)
2. cruise ships and nursing homes

A

norovirus

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18
Q

this virus can be airborne

A

norovirus

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19
Q

clinical course for noro and rotoviruses

A

N/V/D/F

leading to dehydration

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20
Q

noro and rotoviruses initiallty infect +_+__

A

tips of villi in the small bowel

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21
Q

NORO and ROTO role in Diarrheal disease

Study These Flashcards
A

do not activate cAMP-unlike cholera toxin

  • they do cause loss of villious cells-> FUNCTIONAL ALTERATIONS IN SMALL/LARGE intestines
  • >
22
Q

most important factor for protection agfaisnt rreinfection by both rota and noroviruses is….

Study These Flashcards
A

local (intestinal) immunity

23
Q

antibodies to rotaviruses

Study These Flashcards
A

obtained early in life

24
Q

ab’s to noroviruses

Study These Flashcards
A

acquired gradually in childhood and icnrease steadily over life time

25
two vaccines for rotoviruses
rotateq | rotarix
26
rotateq
- Approved for sale in U.S. by FDA in February, 2006 - Pentavalent bovine-human reassortant viruses (serotypes G1-G4 and P8) -Live, attenuated vaccine given orally at 2, 4, and 6 months
27
rotarix
- Human-derived monovalent (G1, P8), live, attenuated vaccine - Administered orally in two doses starting at 6-weeks of age
28
norovirus vaccines
none
29
non-enveloped, icosahedra;, single stranded, +sense RNA | STAR LIKE APPEANCE
Astroviruses
30
after reoviruses-second most common cause of childhood D in children <1 year old
Astroviruses
31
whatr % of 5-10 year olds have Ab's to astroviriuses
80%
32
spread by astroviruses
oral-fecal route
33
peak incidence of astrovrisues
winter-self limiting
34
vaccine for astroviruses
not available
35
picoviridae
enteroviruses
36
small icosahedral nonenveloped + sense RNA viruses
enteroviruses
37
pico=
small-RNA virus
38
name the enteroviruses | picornoviridae
polio enterovirus cocksackie A and B echoviruses
39
causes flaccid paralysis
polioviruses
40
ECHO virus stands for
enteric, cytotoxic, human orphan
41
also an enterovirus-like virus
hepatitis A
42
what differentiates enteroviruses from rhinoviruses
a. acid stability b. replicaiton at 37 degrees * enteroviruses can do both of these thangs
43
spread of enteroviruses
fecal-oral route | humans only reservoir
44
initially replicate in the lymph tissue of URT and Gut
enteroviruses
45
enteroviruses can be cultured from
throat swabs
46
viremia with enteroviruses causes
Spinal cord and brain infectin myocardium skin meninges
47
how quick is enteroviruses in stool and throat
10 days in stool and throat blood in 9 csf in 14
48
vaccines for enteroviruses
polio only
49
adenoviridae
adenovirus
50
large, non enveloped, linear dsDNA
adenovirus
51
two ADENO stereotypes associated with gastroenteritis
40 and 41

Gastrointestinal (9 decks)

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