Wk 21 Flashcards
Oxidised substances=
Reduced substances=
Lose electrons/ energy
Gain electrons/ energy
Free radical=
Have an unpaired electron in outer shell which makes them very unstable and reactive and want to steal an electron from another atom (but this makes that atom a free radical)
What is ROS?
What are ROS derived from?
What does excess ROS oxidise?
Reactive oxygen species (free radicals and peroxides)
Derived from metabolism of O2
oxidizes protein/ lipids/ DNA
How is iron related to ROS?
It catalyzes the reaction that forms ROS
Antioxidants=
What are the main antioxidants from diet?
What is the main antioxidant in the body?
a substance that inhibits oxidation or reactions promoted by oxygen, peroxides or free radicals
Vitamin A, C, E
Glutathione (GSH)
How does the liver detoxify?
(What cells remove forgein material from blood?)
Where does the liver remove waste to?
Cytochrome P450 enzymes convert toxic insoluble compounds into less toxic water sol metabolites that can easily be excreted
Kupffer cells
Gall bladder and kidneys
How does the liver clean the blood?
Kuppfer cells= phagocytic macrophages digest bacteria and other foreign matter in blood
What does the liver synthesize? (6)
Acronym to help remember
What does the liver store? (4)
Acronym to remember
Synthesis= Look left, go back, point up
Lipids (cholesterol, TGs, ketone bodies) Lipoproteins (VLDL) Glucose Bile Proteins Urea
Store= Give fat men (a) try
Glycogen
Fat sol vitamins (D,E,A,K) and vit B12
Metals (iron/ copper)
Triglycerides
What is dangerous about a vit K deficiency?
How does warfarin work?
Can’t ‘K’lot (clot) without vit K so increased risk of haemorrhage
it is an anticoagulant that antagonises the activity of vit K
What are the proteins made by the liver?
5
Albumin (main liver protein) and other carrier proteins
Haemostasis proteins (clotting)
Hormones and prohormones
Apolipoproteins
Enzymes (cytochrome P450)
Bile proteins
What is the main protein in the blood plasma?
What is a marker of liver damage?
What is the most important function of this protein?
What are 6 other cool functions of this protein?
(acronym)
Albumin
Serum albumin
regulate the oncotic pressure of the blood
(To brilliant Albumin, what a duuuude) Transport Buffering Anticoagulant Wound healing/ inflammation Antioxidant Detoxification
How does the liver breakdown/ catabolize Amino Acids?
First step= removal of amine group
Carbon skeleton –> ketoacid–> metabolism
Nitrogen skeleton portion -> ammonia (ammonia converted to less toxic form, urea, in liver)
What is transamination?
What is deamination?
Transfer of amino group from an amino acid to a keto acid (generates a new non-essential AA)
The removal of the amine group as ammonia (ammonia then converted to less toxic form, urea, in liver)
What is urea?
waste product formed from protein breakdown
What is pharmacokinetics?
what the body does with a drug
ADME
(picture a tic tac going through body)
What are xenobiotics?
Examples?
Forgein substances not natural to body (drugs, food additives, processed food, cosmetic products etc)