Womens Health Flashcards Preview

M2 Endo Pharm > Womens Health > Flashcards

Flashcards in Womens Health Deck (18)
Loading flashcards...
1

OC
-whats inside
-adverse effects (5)
---moderate ones (3)
-------serious (5)
-contraindications (7)
-metabolism

Ethynyl E2 and possibly some P4 variant\

HA, N, mastalgia, edema
-breakthrough bleeding, withdrawl bleeding failing to

weight gain+acne+hirustisim (P4 like prgestins), urethral dilations->bacteruria, ammonoreha for several months after stopping

low incidence-Venous thrombomolic disease, MI, Cerebrovascular disease, Gi d/o, depression

CV, Cerebrovascular, thromboembolic hx
Migrane with aura, liver/gallbaldder disease, htn

cyp3a4

2

OC benefits unrealted to contraception (3 main) and 4ish others

reduce risk of-ovarian cysts, endometrial and breast cancer

lower incidence of ectopic preg

prementstual sdx, dysmenorrhea, and endometriosis may be ameliorated

acne and hirsutism may be ameliorated

3

Ortho Evra
-what is it
-mech
-usage

Transdermal patch

Synthetic ethynyl estradio l adn P4 at high leve (but goes through slowly)

3 wks with pathc, 1 week off

4

Nuvaring
-what is it
-usage

Flexible ring with ehtinyl E2 and P4

insert ring for 3 weeks and 4th week is ring free

5

Implanon
-aka
-what is it
-usage

Nexplanon-subdermal implant

contains ONLY progestin

peka serum concetration in first few weeks-3 year ovulation supression

6

Depo Provera
-what is it (and what in it)
-usage
-adv
-disadv

Injectable

progestin only

Im admin 1x/3mo

long duratio nof action and decreased menses

decreased bone density, weight gain, menstural irreg, depression, doctor admin

7

Levonorgestrel

Morning after pill (can be e2, p4, or both)

LEvo is just P4

99% effective

8

Mifepristone

P4 receptor antagonist=luteolytic effect->effective postcoital contraceptive

9

Clomiphene
-what is it
-mech
-uses
-dose
-side fx

SERM-selective E2 receptor modulator

increase in secretion of gonadotropins and E2 by inhibiting E2 negative feedback effect

stim ovulation in oligomenorhrhea/amenorrhea and ovulatory dysfxn

-single course=somnge ovulation-do repeatedly until preg

hotflashes, NV, dperession, heavy meses, weight gainm multiple preg

10

Leuprolide
-what is it
-use

GnRH agaonist

for anovulatory women who fail to respond to other less complicated forms of trx
- MC use is controled ovarian hyperstim for IVF

11

Ceftrixaone

3rd gen cephalosprin
-inhibit biosyn of bacerial cell wall (cidal)

PID-gonorrhea

12

Azyhthomycin and Doxy
-use
-mech
-metabolism
-cidal vs static

PID-CLAP

Azithromycin-macrolide-protein synthesis inhibitor 50s ribosomal subinit

Doxycycline-target 30S ribosomal subunit

both are long acting and orally bioavilie

bacteriostatic

13

STDs that cause vaginal discharge and trx

CLAP and gonorrhea

Trichomonas vaginitis
-flagellated protozoan
-malodorous discharge
-metronidazone

Herpes vaginitis-acyclovir, valacyclovir, famiciclovir

14

Metronidazole
-mech
-useage
-dosage
-side fx
-rare side fx
-contradincation

- pyruvate ferredoxin oxidorreductase (PFOR) is required-found isn susceptible microbes
- activation using ferredoxin as electron donor results in toxic radical
-chews up DNA

trx Trich

single dose

GI irritation (kills enteric microflora)-lessened with food, HA

neutropenia, pancreatitis, CNS tox

(12 hour window)Nursing, Preg, CNS disease

15

herpes Vaginitis trx
-microbe
-mech
-difference between 3 types
-doses
-3 effects
-side fx
-special side fx

get it from HSV2

acyclovir, valacyclovir, famcicvlor
- competitiive inhibition of DNA polyermase of virus
-needs viral kinase to work
-chain termination after incorporation

Van and fam-are prodrugs of acyclovir

acyclovir 3x daily, fam 3x, vala 1x daily (best)

shorter duration, reduced ulcer heal time, decrease transmission

N, V, D, HA (eat before)

high dose valacyclovir-confusion ,hallucinations, seizures

16

tamoxifen use

E2 + breast cancer

but agonist in endometrium

17

Fenesteride mech and use

5alpha reductase inhibitor
- no DHT production

trx BPH

takes months to work

18

anastrazole

CYP19 inhibitor