Hypothalamic and Pituitary Flashcards Preview

M2 Endo Pharm > Hypothalamic and Pituitary > Flashcards

Flashcards in Hypothalamic and Pituitary Deck (12)
Loading flashcards...
1

Somatropin
+1
What is it?
Admin/times per week
uses
tox (peds vs adults)

Somatotropin

Recombinant GH

Subcut administration 6-7x/wk

GH def, Prader willi, turner, idiopathic short stature (GH def has much more robust effect)

Peds-Rare-pseudotumor cerebri (increase ICP), progression of scoliosis, hyperglycemia (induction of peripheral insulin resistance)
- GH def pts should check other anterior hormones that need trx

Adullts-more likely-peripheral edema, myalgias, arthalgias, carpel tunnel

2

Mecasermin
-use
-side fx
-special

recombinant IGF1

for growth failure children not responsive to exogenous GH

hypoglycemia (drug activates inuslin receptor)

require carbs 20 mins before or after admin

3

Octreotide
-class
-+1
-use
-side fx
-method

GH Antagnoists (long acting somatostatin analogs)

Lanreotide

usually GH secreting pituitary adenoma->acromegaly

oct-subcut injections, NV, gallstones, bradycardia, CONDUCTION PROBLEMS

4

Pegvisomant
-class
-use
-method

GH receptor antagnoist (oct/lanreo do not work)

acromegaly

subcut daily

5

Urofollitropin
-class
-+2
-use

Purified FSh

Follitropin alpha and beta->shorter t1/2 and much more expensive

making infertile women fertile with FH def

6

Lutropin
-class
-use

Recombinant LH

Used in comination with follitropin alpha for stimualtion of cfollicular development in infertile women with profound LH def

7

Choriogonadotropin alpha
-use (2)
-tox (2)

Recombinant hCG

Controlloed ovarian hyperstimulation->IVF
Trx infertility-stimualte spermatogenesis in men or ovulatio in women (if refractory)

Ovarian hyperstimulation syndrome->ovarian enlargemnt, ascites, hypovolemia->schock
Multiuple pregnancies

8

Leuprolide
+4 (but 1 common name)
-mech
-uses 4 and which are indicated
-side fx (men vs women)

-relins

Nonpulsatile GnRH agonists that inhibit pituitary release of FSH and LH

endometriosis
Uterine Leiomyoma (fibroids)
Prostate cancer
Central preciocious puberty


Women-menopause sx (hot flashes, sweats, diminished libido, vaginal dryness, depressioN), ovarian cysts, reduced bone density and osteoporosis

Men-hot flashes, gynecomastia, decreased libido, reduced bone density

9

Ganirelix
+2
2 uses
side fx

-Relix drugs

-inhibit secretion of FSH and LH in more complete manner than do GnRH agonists

Ganirelix and cetrorelix-ovarian hyperstim with low risk of OHSS

Degarelix-advance porasate cancer

Degarleix->andorgen deprivation (hot flashes and edema)

10

Bromocriptine
-mech
-+1
-use
-side effect men vs women
-difference between the two
-side FX

dopamine agonists

cabergoline

prolactin-secreting adenoma causing no ovulation

amenorrhea and galactorhhea in women
Libido loss and infertility in men

Cabergoline has higher affinity for D2 receptors than bromociptine and has less N but has cardiac valvulopathy.

N,HA, Light headedness, orthohypothension, fatigue->patient's discontinue

11

Oxytocin
-3 uses
-tox (2)
-contraindications

small doses-increases freq and force of uterine contractions

synthetic-induce labor for conditions requiring early vaginal delivery-uncontrolled mom DM, worsenig preeclampsia, intrauterine infection

Control uternie hemorrhage in immediate postpartum period

usually rare-excessive stimulation of uterine contractions (fetal distres, placental abruption or uterine rupture) or inadvertent activation of ADH (excessive fluid retention)

fetal distress, abnL fetal presentation, small pelvis, predispotion for uterine rupture

12

TH Drugs
-when to use each
-mech
-side effects (3)

Methemazole and PTU
- use Meth unless pregnant
-both work same way (MPO inhibitors), but PTU also inhibits peripheral conversion of T4 to T3

Rash, hepatitis (PTU), agranulocytosis