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Flashcards in Wound Healing Deck (48)
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1

What are the 3 phases of Healing?

1. Inflammatory Stage (0-2 wks)
2. Proliferation/Repair (days to 6 weeks)
3. Maturation/Remodeling (6 weeks to 2 years)

2

Five things we must know about Inflammatory Phase:

1. understand pathogenic mechanisms
2. amplification of initial response is key
3. inflammation persists until stimulus is removed
4. inflammation is potentially dangerous
5. therapeutic strategies target critical control points in cycle

3

What is the key to responding to inflammation?

amplification

4

What are the cardinal signs? (5)

-redness
-edema
-head
-pain
-loss of function

5

what type of inflammation contains plasma cells, lymphocytes, and macrophages?

Chronic inflammation

6

what are three outcomes of acute inflammation? (healing factors)

-resolution
-abscess
-scar

7

the hydrostatic pressure of blood is normally nearly balanced by oncotic pressure of plasma proteins

Starling's Law

8

What are the three phases of inflammation?

Initiation
Amplification
Termination

9

What phase of inflammation consists of changes in microvasculature, structural changes leading to extravasation and emigration of WBCs to site?

Initiation Phase

10

Describe amplification? Phase 2 of inflammation

when both soluble mediators and cellular inflammatory systems are activated and amplified

11

what phase is accomplished by specific inhibition or dissipation of mediators

Termination phase of inflammation

12

What are some primary effects of inflammation?

vasodialation/vasoconstriction
activation of inflammatory cells
chemotaxis
cytotoxicityy (kills cells)
tissue degradation
pain
fever

13

What are the sources of inflammatory mediators?

cell derived ( proteins, phospholipids, mast cells, platelets)
inactive precursors in plasma

14

What are:
-Vasoactive amines
-Plasma Proteins
- Kinin System ( powerful vasodialators)
-Coagulation pathway
- Fibrinolytic pathway (dissolves clots)
- Arachidonic acid metabolites
-Platelet activating factor
- Cytokines
- nitric oxide (peroxide)

Chemical mediators of inflammation

15

what is a vasoactive amine that is abundant in mast cells that increases permeability around blood vessels?

Histamine

16

what is a vasoactive amine that is similiar to histamine, and released after platet aggreation

Serotonin

17

What is the most important product of the kinin system in inflammation? what does it do?

Bradykinin and vascular dilation and pain

18

What is the vascular Reaction in inflammation

-immediate vasoconstriction
-clotting
-margination and diapedesis
-neutrophils and Macrophages
- vasodilation

19

What stage of inflammation is when PMNs and macrophages are recruited to the site of injury by blood?

Apmlification

20

how long is recruitement of macrophages in inflammation?

6- 48 hours

21

what is the process of directed cell migration which is a dynamic and energy dependent?

chemotaxis

22

what is a pivotal cell that secretes many diff molecules under various influences

macrophage

23

what activates macrophages?

platelets
cytokines
fibronectin

24

What can damage the host?

extracellular release of enzymes and activated oxygen species

25

What is present in chronic inflammation?

mononuclear cells (macrophages, lymphocytes and plasma cells)
ongoing inflammation causes tissue destruction

26

What is not present in chronic inflammation?

neutrophils only macrophages and monocytes

27

What is the clinical hallmark of inflammtion?

fever

28

most common gram negative septicemia (bacteria in blood)

shock

29

Types of drainage:

-Serous
-Serosanguineous
-Purulent
-Dessication (scab)
-Slough
-Eschar
-Maceration

30

clear/clear yellow

serous