Woundcare 2b/c Flashcards
(79 cards)
Critical colonization
Point at which the host immune response is no longer able to control microorganisms in wound bed
Bacteria not yet invaded soft tissue
Arrested wound healing and unhealthy appearance of granulation tissue
Topical treatments
Cadexomer iodine
Silver
Xeroform
Hypchlorous acid soak
Infection
Invasion and multiplication of microorganisms in body tissue
Results in local cellular injury
Host defenses are overwhelmed
Infection equation
(# organisms x virulence)/host resistance
Host resistance
Immune repsonse
Blood supply
General health status
Local factors
S/s of infection local
Erythema Edema Warmth Increase pain Purulent Induration
S/s infection systemic
Fever
Elevated WBC
Red streaks from wound
Confusion or agitation
S/s infection chronic
New/increased slough Friable granulation tissue Foul odor Increased wound breakdown Sudden high glucose in diabetics Increase/changes in exudate
Clinical diagnosis of infection
Bacterial load 10^5-10^6 (will not heal)
NERD and STONEES
Sibbalds cute for superficial and deep compartment infection/inflammation
Symptoms and theranostic test
NERDS
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STONEES
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Gold standard for indicated dx
Tissue biopsy
Not w/in PT scope
Tx infection
Cleansing/ irrigation Debridement Topical anti microbial Topical antiseptics Abx
Topical antiseptics
Acetic acid Alcohol Chlorhexidine gluconate Dakins solution Gentian violet Hydrogen peroxide Povidone iodine **Hypochlorite acid - safe
Microorganism defenses
Toxins
Anderence of organism
Biofilms
Invasive factors (protease)
Endotoxins
Lipids and polysaccharides related by lysis of gram negative bacteria
Causes destruction of growth factors, receptors, tissue components
Decrease collagen deposition and cross linking, affecting tensile strength
Associated w/ surgical wound dehiscence
Extotoxins
Proteins related by both gram positive and negative bacteria during proliferation —> generalized tissue necrosis at wound surface
Biofilms
Structured community of bacteria cells enclosed in self produced polysacchardie matrix
Quorum sensing
Comm processes among cells in biofilm —> perceive how many other bacteria are in close proximity, regulation of many different processes
Disadvantage of biofilm
Resistance to anti microbial, abx, phagocytes Ability to enter into latent states Increasing species diversity Persister cells Altered gene expression
Biofilm tax
Wound cleansing/irritation Serial debridement Cadexomer iodine Flouroquinolone abx Pulsed, low dose abx Xylitol Lactoferrin
Biofilm irrigation
35 ml syringe w/ 18 gauge angiocatheter 8-12 psi
Water as effective as normal saline except immunocompormised or poor water quality
Hydrotherapy
Pulsed lovage w/ or w/out suction
Whirlpool
Softening necrotic tissue, reduce bioburden, remove debris, promot granulation, treatments of tunnels and undermining