Flashcards in XIV - The Kidneys and Its Collecting System (with pics) Deck (154)
Pathogenesis: Excessive complement activation, with autoantibodies against C3 CONVERTASE, which lead to uncontrolled cleavage of C3 and activation of the pathway.
Dense deposit disease (TOPNOTCH) Robbins Basic Pathology, 9th ed. P.527
How do you differentiate the three main causes of crescenteric glomerulonephritis from one another (Anti-GBM-mediated, Immune complex-mediated, and pauci-immune)?
Anti-GBM on IF shows LINEAR IgG and C3 deposits; Immune-complex mediated on IF shows granular pattern; pauci-immune on IF shows NO deposits (TOPNOTCH) Robbins Basic Pathology, 9th ed. P.532-533
Pathognomonic gross feature of papillary necrosis.
Gray-white to yellow necrosis of the apical two thirds of the pyramids. Remember also the three predisposing conditions: Diabetes, urinary tract obstruction, and analgesic abuse. (TOPNOTCH) Robbins Basic Pathology, 9th ed. P.535