XV - The Oral Cavity and the GI Tract Flashcards Preview

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Flashcards in XV - The Oral Cavity and the GI Tract Deck (141)
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121

What are the two key pathogenic abnormalities seen in Idiopathic Inflammatory Bowel disease?

Strong immune response against normal flora and defects in epithelial barrier function(TOPNOTCH)

122

Gross morphology: intestinal wall is rubbery and thick, as a consequence of edema, inflammation, fibrosis and hypertrophy of the muscularis propria

Crohn disease(TOPNOTCH)

123

Morphology: small intestinal mucosa laden with distended macrophages in the lamina propria which are PAS positive and contains numerous bacilli and diastase resistant granules

Whipple disease(TOPNOTCH)

124

Intestinal lipodystrophy is associated with what disease entity?

Whipple disase(TOPNOTCH)

125

Morphology: diffuse severe atrophy and blunting of villi, with a chronic inflammatory infiltrate in the lamina propria

Celiac disease(TOPNOTCH)

126

Morphology: focal crypt cell necrosis or apoptosis with minimal to absent inflammatory cell response in the lamina propria

Acute GVHD(TOPNOTCH)

127

Morphology: marked blunting of the small intestinal villi with a mixed inflammatory infiltrate resembling the atrophic stage of celiac disease

Giardiasis(TOPNOTCH)

128

Morphology: superficial erosion of the mucosa and an adherent pseudomembrane of fibrin, mucus, and inflammatory debris

Pseudomembranous colitis(TOPNOTCH)

129

Morphology: small intestinal mucosa usually exhibits modestly shortened villi and infiltration of the lamina propria by lymphocytes

Viral gastroenteritis(TOPNOTCH)

130

What virus affecting the GIT can produce a flat mucosa resembling celiac sprue?

Rotavirus(TOPNOTCH)

131

Morphology: characterized by the absence of ganglion cells and ganglia in the muscle wall and submucosa of the affected segment

Congenital Aganglionic Megacolon(TOPNOTCH)

132

Stercoral ulcers are seen in what disease entity?

Congenital aganglionic megacolon(TOPNOTCH)

133

The majority of these tumors are positive for c-KIT (CD 117)

Gastrointestinal Stromal Tumor(TOPNOTCH)

134

What is the most common site of gastric carcinoma?

Pylorus and anthrum 50%-60%(TOPNOTCH)

135

What is the most favored site of gastric carcinoma?

lesser curvature of the anthropyloric region(TOPNOTCH)

136

What is the morphologic feature of gastric carcinoma that has the greatest impact on clinical outcome?

Depth of invasion(TOPNOTCH)

137

This is a variant of gastric carcinoma composed of neoplastic intestinal glands resembling those of colonic adnocarcinoma and the neoplastic cells contain apical mucin vacuoles and abundant mucin may be present in gland lumens

Intestinal type(TOPNOTCH)

138

This is a variant of gastric carcinoma which is composed of gastric type mucous cells, which generally do not form glands, but rather permeate the mcosa and wall as scattered individual cells or small clusters in an infiltrative growth pattern

Diffuse type(TOPNOTCH)

139

What is the most common type of gastric polyp?

Hyperplastic polyp(TOPNOTCH)

140

In gastritis, histologically, what signifies an active inflammation?

Presence of neutrophils above the basement membrane.(TOPNOTCH)

141

H. pylori infection in duodenal ulcers is present in about how many percent of patients?

Virtually ALL (70% in patients with gastric ulcer(TOPNOTCH)