XXIII - The Nervous System (with pics) Flashcards Preview

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Flashcards in XXIII - The Nervous System (with pics) Deck (213)
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Although any type of cell within the CNS can be infected with CMV, the virus tends to localize at what particular area in the brain?

Paraventricular subependymal regions(TOPNOTCH)


What is the principal neurologic manifestation of Von Hippel Lindau Disease?

Cerebellar capillary hemangioblastoma(TOPNOTCH)


Antoni A and Antoni B patterns of growth are seen in what tumors of the CNS? SEE SLIDE 23.24.

Schwannoma. In Antoni A areas, cells align to produce nuclear palisading, with alternating bands of nuclear and anuclear areas called VEROCAY BODIES. (TOPNOTCH) Robbins Basic Pathology, 9th ed, p 807.


Morphology: Histologic appearance similar to anaplastic astrocytoma with the additional feature of necrosis and vascular or endothelial cell proliferation. SEE SLIDE 23.25

Glioblastoma multiforme(TOPNOTCH)


Pseudopalisading. SEE SLIDE 23.25

Glioblastoma multiforme(TOPNOTCH)


Glomeruloid body

Glioblastoma multiforme(TOPNOTCH)


Lesion of what area of the brain appear to be the best correlate of the memory disturbance and confabulation seen in Korsakoff syndrome?

Medial dorsal nucleus of the thalamus(TOPNOTCH)


The spinal cord shows loss of axons and gliosis in the posterior columns, the distal portions of the corticospinal tracts, and the spinocerebellar tracts.

Friedreich Ataxia(TOPNOTCH)


The abnormalities are predominantly in the cerebellum,with loss of Purkinje and granule cells; there is also degeneration of the dorsal columns, spinocerebellar tracts and anterior horn cells and a peripheral neuropathy

Ataxia Telangiectasia(TOPNOTCH)


Gross morphology: pallor of the substantia nigra and locus ceruleus

Parkinson Disease(TOPNOTCH)


Gross morphology: the brain shows pronounced, frequently asymmetric, atrophy of the frontal and temporal lobes with conspicuous sparing of the posterior two thirds of the superior temporal gyrus

Pick Disease(TOPNOTCH)


What are the 3 major microscopic abnormalities of Alzheimer disease?

Neuritic/Senile PlaquesNeurofibrillary tanglesAmyloid angiopathy. SEE SLIDE 23.11. (TOPNOTCH)


What is the principal clinical manifestation of Alzheimer disease?



What is the most common cause of dementia in the elderly?

Alzheimer Disease(TOPNOTCH)


Gross morphology: Variable degree of cortical atrophy with widening of the cerebral sulci that is most pronounced in the frontal, temporal, and parietal lobes with compensatory ventricular enlargement (hydrocephalus ex vacuo)

Alzheimer Disease(TOPNOTCH)


Neurotic plaques are focal, spherical collection of dilated, tortuous, silver staining neuritic processes often around a central amyloid core, which may be surrounded by clear halo, and can be stained with Congo red. SEE SLIDE 23.11. What is the most predominant component of this plaque core?

AB peptide(TOPNOTCH)


Neurofibrillary tangles are bundles of filaments in the cytoplasm of the neurons that displace or encircle the nucleus. SEE SLIDE 23.11. What is the major component of this structure?

Tau proteins(TOPNOTCH)


Hirano bodies. SEE SLIDE 23.11

Alzheimer's disease (TOPNOTCH)


What is the principal neurologic manifestation of Von Hippel Lindau Disease?

Cerebellar capillary hemangioblastoma(TOPNOTCH)


Patients with Von Hippel Lindau Disease has the propensity to develop what type of carcinom?

Renal Cell Carcinoma(TOPNOTCH)


These are firm areas of the cortex that, in contrast to the softer adjacent cortex, have been likened to potatoes and are composed of haphazardly arranged neurons that lack the normal laminar organization of neocortex.

Cortical hamartomas or "tubers' of Tuberous Sclerosis (TOPNOTCH)


Malignant Peripheral Nerve Sheath Tumor (MPNST, Malignant Schwannoma) is strongly associated with what type of Familial Tumor Syndrome?

Neurofibromatosis Type 1(TOPNOTCH)


What are the 5 most common carcinoma that metastasize to the brain?

Lung, breast, Melanoma, Kidney, and GIT. (TOPNOTCH)


What is the most common CNS neoplasm in immunosuppressed patients, including those with AIDS and immunosuppression after transplantaion?

Primary CNS Lymphoma(TOPNOTCH)


Morphology: Characterized by amild to moderate increase in the number of glial cell nuclei, somewhat variable nuclear pleomorphism, and an interveing feltwork of fine, GFAP positive astrocytic cell processes that give the background a fibrillary appearance.

Well differentiated fibrillary astrocytomas(TOPNOTCH)


Morphology: Perivascular pseudorosettes SEE SLIDE 23.26



Morphology: The anterior roots of the spinal cord are thin; the precentral gyrus may be atrophic and demonstrates a reduction the number of anterior horn neurons throughout the length of the spinal cord with associated reactive gliosis. Remaining neurons often contain Bunina bdoies and PAS positive cytoplasmic inclusions.

Amyotorphic Lateral Sclerosis(TOPNOTCH)


Morphology: composed of bipolar cells with long, thin "hairlike" processes that are GFAP- Positive; Rosenthal fibers, eosinophilic granular bodies, and microcysts are often present. SEE SLIDE 23.27.

Pilocytic Astrocytoma (TOPNOTCH)


Morphology: Characterized by areas of stromal response with collagen and reticulin deposition and nodules of cells forming "pale islands" that have more neuropil and lack the reticulin deposition

Desmoplastic variant of Medulloblastoma(TOPNOTCH)


Gross morphology: the brain is small and shows striking atrophy of the caudate nucleus and the putamen. The globus pallidus may be atrophied secondarily, and the lateral and third ventricles are dilated.

Huntington Disease(TOPNOTCH)