Year 2 Pharmacology Flashcards Preview

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Flashcards in Year 2 Pharmacology Deck (85)
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1

Amoxicillin

beta lactam antibiotic
broad spectrum

2

Methicillin

beta lactam antibiotic
gram positive

3

cefuroxime

transpeptidase inhibitor
broad spectrum antibiotic

4

benzylpenicillin

beta lactam
gram positive

5

oxytetracycline

30s inhibitor
broad spectrum

6

erythromycin

50s inhibitor
broad spectrum

7

Gentamycin

30s/50s inhibitor
aminoglycoside
broad spectrum
oto- and nephro-toxicity

8

Rifampicin

RNA polymerase inhibitor
broad spectrum
TB

9

Trimethoprim

DHF reductase inhibitor
UTI

10

Suxamethoxazole

PABA analogule
UTI

11

Vancomycin

peptidoglycan inhibitor
interferes with cell wall production
drug of last resort

12

Collistin

Polymixin
membrane detergent

13

Ciprafloxacin

broad spectrum
topoisomerase II inhibitor

14

Fusidic Acid

EF-G inhibitor
creams and eye drops

15

Aciclovir

DNA polymerase inhibitor
nucleotide analogue competes with endogenous nucloetide

16

Amantidine

viral ion channle disruptor - this prevents viral uncoating

17

Amprenavir

protease inhibitor

18

Phenoxymethylpenicillin

transpeptidase inhibitor
gram positive

19

Zidovudine

nucloside reverse transcriptase inhibitor

20

Clotrimazole

antifungal
prevents production of ergosterol

21

Fluconazole

antifungal
prevents the production of ergosterol

22

Nystatin

antifungal
binds to ergosterol therefore causes formation of pores

23

Amphoteraxcin

antifungal
binds to ergosterol therefore causes the formation of pores

24

Pyrimethamine

Antimalarial
inhibits DHF reductase
prevents schizoint division

25

Quinine

Antimalarial
Inhibits Haem polymerase; prevents parasite detoxification of blood
also used to treat Crohn's disease (unclear mechanism)

26

Artemether

Antimalarial
results in the formation of oxygen free radicals which damage infected red blood cells

27

Griseofulvin

fungal mitosis inhibitor

28

Clobetasone

steroid

29

Decarbazine

alkylating chemotherapy agent

30

Cyclophosphamide

alkylating chemotherapy agent

31

Rituximab

B cell CD20 antibody
used to treat blood cancers

32

Doxorubicin

anthracycline antibiotic
inhibits topoisomerase II
chemotherapy agent

33

Pacitaxal

microtubule stabilisation agent
prevents mitosis
used to treat advanced ovarian and breast cancers

34

5-flurouracil

competes with endogenous nucleotides for encorporation into DNA
prevents DNA replication

35

Etoposide

inhibits topoisomerase II
chemotherapy agent

36

Vinblastine

tubulin polymerase inhibitor
destabilises the mitotic spindle

37

Imatinib

tyrosine kinase inhibitor
used to treat CML

38

Tretinoin

vitamin A analogue
used to treat skin conditions and promyelocytic leukaemia

39

Cisplatin

alkylating chemotherapy agent

40

what is the suffix of ACE inhibitors

-IPRIL

41

Amiloride

inhibits ENaC

42

furosemide

loop diuretic
inhibits NKCC2

43

thiazide diuretic

inhibits NCC

44

mannitol

osmotic load diuretic

45

doxazosin

alpha-1 adrenoreceptor antagonist

46

Spironolactone

aldosterone antagonist
potassium sparing diuretic

47

Acetazolamide

inhibits carbonic anhydrase

48

Phenobarbitol

barbituate
GABA agonist

49

Desogestrel
Etonogestrel
Levonorgestrel

synthetic versions of progesterone
Contraception

50

Oxytocin

used to induce labour
stimulates uterine contraction

51

Dinoprostone

Prostaglandin E2
used to induce labour

52

Azathioprine

inhibits purine synthesis
used to treat autoimmune conditions

53

Diclofenac

NSAID

54

Celecoxib

selective COX2 inhibitor

55

Sulfasalazine

immunosuppressant
used to treat autoimmune conditions (RA, IBD)

56

Ciclosporin

Immunosuppressant; inhibits calcineurin

57

Salcatonin

Calcitonin preparation
Osteoporosis

58

Raloxifine

SERM
HRT; osteoporosis

59

Alendronate

Bisphosphonate
Osteoporosis

60

Isoflurane

Inhaled anaesthetic agent

61

Propofol

intravenous anaesthetic

62

Lamotrigine

sodium channel inhibitor
used to treat epilepsy

63

Phenytoin

sodium channel inhibitor
used to treat epilepsy
not used for absence seizures

64

Carbamezipine

sodium channel inhibitor
used to treat epilepsy

65

Valproate

inhibits GABA transaminase therefore potentiates the action of GABA
epilepsy

66

ethosuximide

Ca channel inhibitor
absence seizures

67

donepezil

acetycholinesterase inhibitor
alzheimers

68

memantine

NMDA antagonist (reduces glutamate toxicity)
alzheimer's

69

Salbutamol

SABA
beta 2 agonist

70

salmeterol

LABA
beta 2 agonist

71

formeterol

LABA
beta 2 agonist

72

montelukast

Leukotriene receptor antagonist
asthma

73

Ipratropium
Tiotropium

anticholinergic bronchodilator
COPD

74

Lidocaine

sodium channel blocker (Class I antiarrhythmic)
slows rate of depolarisation

75

Atenolol

beta blocker
class II antiarrythmic

76

Amiodarone

potassium channel blocker
class III antiarrythmic
prolongs repolarisation and refractory period

77

Verapamil

calcium channel blocker
class IV antiarrythmic
shortens plataeu

78

Chlorpromazine

Dopamine antagonist
antiemetic

79

Allopurinol

purine antagonist
used to treat gout

80

Kaolin

adsorption agent (adsorbs water)
Anti-diarrhoea drug

81

Isphagia Husk

bulk forming laxative
adds to bulk therefore aids peristalsis

82

Lactulose

osmotic laxative

83

Bisacodyl

laxative

84

Atropine

antimuscarinic used to abolish reflex vagal cardiac slowing/asystole and bradycardia
may lessen degree of partial heart block
stimulates AV node

85

Adenosine

slows conduction though the AV node
used to see if tachycardia is supraventricular (will abolish) or ventricular (no effect)