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HYMS Pharmacology > Year 2 Pharmacology > Flashcards

Year 2 Pharmacology Flashcards

(85 cards)

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1
Q

Amoxicillin

A

beta lactam antibiotic

broad spectrum

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2
Q

Methicillin

A

beta lactam antibiotic

gram positive

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3
Q

cefuroxime

A

transpeptidase inhibitor

broad spectrum antibiotic

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4
Q

benzylpenicillin

A

beta lactam

gram positive

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5
Q

oxytetracycline

A

30s inhibitor

broad spectrum

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6
Q

erythromycin

A

50s inhibitor

broad spectrum

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7
Q

Gentamycin

A

30s/50s inhibitor
aminoglycoside
broad spectrum
oto- and nephro-toxicity

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8
Q

Rifampicin

A

RNA polymerase inhibitor
broad spectrum
TB

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9
Q

Trimethoprim

A

DHF reductase inhibitor

UTI

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10
Q

Suxamethoxazole

A

PABA analogule

UTI

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11
Q

Vancomycin

A

peptidoglycan inhibitor
interferes with cell wall production
drug of last resort

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12
Q

Collistin

A

Polymixin

membrane detergent

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13
Q

Ciprafloxacin

A

broad spectrum

topoisomerase II inhibitor

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14
Q

Fusidic Acid

A

EF-G inhibitor

creams and eye drops

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15
Q

Aciclovir

A

DNA polymerase inhibitor

nucleotide analogue competes with endogenous nucloetide

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16
Q

Amantidine

A

viral ion channle disruptor - this prevents viral uncoating

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17
Q

Amprenavir

A

protease inhibitor

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18
Q

Phenoxymethylpenicillin

A

transpeptidase inhibitor

gram positive

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19
Q

Zidovudine

A

nucloside reverse transcriptase inhibitor

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20
Q

Clotrimazole

A

antifungal

prevents production of ergosterol

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21
Q

Fluconazole

A

antifungal

prevents the production of ergosterol

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22
Q

Nystatin

A

antifungal

binds to ergosterol therefore causes formation of pores

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23
Q

Amphoteraxcin

A

antifungal

binds to ergosterol therefore causes the formation of pores

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24
Q

Pyrimethamine

A

Antimalarial
inhibits DHF reductase
prevents schizoint division

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25
Quinine
Antimalarial Inhibits Haem polymerase; prevents parasite detoxification of blood also used to treat Crohn's disease (unclear mechanism)
26
Artemether
Antimalarial | results in the formation of oxygen free radicals which damage infected red blood cells
27
Griseofulvin
fungal mitosis inhibitor
28
Clobetasone
steroid
29
Decarbazine
alkylating chemotherapy agent
30
Cyclophosphamide
alkylating chemotherapy agent
31
Rituximab
B cell CD20 antibody | used to treat blood cancers
32
Doxorubicin
anthracycline antibiotic inhibits topoisomerase II chemotherapy agent
33
Pacitaxal
microtubule stabilisation agent prevents mitosis used to treat advanced ovarian and breast cancers
34
5-flurouracil
competes with endogenous nucleotides for encorporation into DNA prevents DNA replication
35
Etoposide
inhibits topoisomerase II | chemotherapy agent
36
Vinblastine
tubulin polymerase inhibitor | destabilises the mitotic spindle
37
Imatinib
tyrosine kinase inhibitor | used to treat CML
38
Tretinoin
vitamin A analogue | used to treat skin conditions and promyelocytic leukaemia
39
Cisplatin
alkylating chemotherapy agent
40
what is the suffix of ACE inhibitors
-IPRIL
41
Amiloride
inhibits ENaC
42
furosemide
loop diuretic | inhibits NKCC2
43
thiazide diuretic
inhibits NCC
44
mannitol
osmotic load diuretic
45
doxazosin
alpha-1 adrenoreceptor antagonist
46
Spironolactone
aldosterone antagonist | potassium sparing diuretic
47
Acetazolamide
inhibits carbonic anhydrase
48
Phenobarbitol
barbituate | GABA agonist
49
Desogestrel Etonogestrel Levonorgestrel
synthetic versions of progesterone | Contraception
50
Oxytocin
used to induce labour | stimulates uterine contraction
51
Dinoprostone
Prostaglandin E2 | used to induce labour
52
Azathioprine
inhibits purine synthesis | used to treat autoimmune conditions
53
Diclofenac
NSAID
54
Celecoxib
selective COX2 inhibitor
55
Sulfasalazine
immunosuppressant | used to treat autoimmune conditions (RA, IBD)
56
Ciclosporin
Immunosuppressant; inhibits calcineurin
57
Salcatonin
Calcitonin preparation | Osteoporosis
58
Raloxifine
SERM | HRT; osteoporosis
59
Alendronate
Bisphosphonate | Osteoporosis
60
Isoflurane
Inhaled anaesthetic agent
61
Propofol
intravenous anaesthetic
62
Lamotrigine
sodium channel inhibitor | used to treat epilepsy
63
Phenytoin
sodium channel inhibitor used to treat epilepsy not used for absence seizures
64
Carbamezipine
sodium channel inhibitor | used to treat epilepsy
65
Valproate
inhibits GABA transaminase therefore potentiates the action of GABA epilepsy
66
ethosuximide
Ca channel inhibitor | absence seizures
67
donepezil
acetycholinesterase inhibitor | alzheimers
68
memantine
``` NMDA antagonist (reduces glutamate toxicity) alzheimer's ```
69
Salbutamol
SABA | beta 2 agonist
70
salmeterol
LABA | beta 2 agonist
71
formeterol
LABA | beta 2 agonist
72
montelukast
Leukotriene receptor antagonist | asthma
73
Ipratropium | Tiotropium
anticholinergic bronchodilator | COPD
74
Lidocaine
sodium channel blocker (Class I antiarrhythmic) | slows rate of depolarisation
75
Atenolol
``` beta blocker class II antiarrythmic ```
76
Amiodarone
``` potassium channel blocker class III antiarrythmic prolongs repolarisation and refractory period ```
77
Verapamil
``` calcium channel blocker class IV antiarrythmic shortens plataeu ```
78
Chlorpromazine
Dopamine antagonist | antiemetic
79
Allopurinol
purine antagonist | used to treat gout
80
Kaolin
``` adsorption agent (adsorbs water) Anti-diarrhoea drug ```
81
Isphagia Husk
bulk forming laxative | adds to bulk therefore aids peristalsis
82
Lactulose
osmotic laxative
83
Bisacodyl
laxative
84
Atropine
antimuscarinic used to abolish reflex vagal cardiac slowing/asystole and bradycardia may lessen degree of partial heart block stimulates AV node
85
Adenosine
slows conduction though the AV node | used to see if tachycardia is supraventricular (will abolish) or ventricular (no effect)

HYMS Pharmacology (2 decks)

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