Zika Virus

Question 1

Transmission of Zika virus

Answer 1

1. Mosquitos
2. Vertical
3. Sex

Question 2

Symptoms of Zika Virus

Answer 2

1. Most are asymptomatic
2. Incubation 2-14 days
3. Fever, rash, conjunctivitis, arthralgia, malaise, headache

Question 3

Differentials if history of travel (Zika)

Answer 3

Dengue, malaria, chikungunya

Question 4

Management of potential Zika virus exposure (periconception or pregnancy)

Answer 4

1. Early specialist advice
2. If exposure ≤2 weeks ago
   a. symptomatic: urine zika PCR + IgG + IgM, repeat in 2 weeks if neg
   b. asymptomatic: collect samples for testing and hold for future testing, repeat in 2 weeks
3. If exposure 2-4 weeks ago perform tests, no need to repeat
4. If exposure >4 weeks ago perform Ig M and IgG only
5. Refer to MFM if anything positive

Question 5

Congenital Zika Virus signs

Answer 5

• Severe microcephaly
• Decreased brain tissue with subcortical calcifications
• Eye abnormalities (macular scarring, retinal focal pigmentation)
• Hypertonia
• Joint abnormalities (arthogryposis, talipes)
• Other (dysphagia, seizures, other eye findings, disrupted brain development or absent brain structures)
  Long term sequale not yet defined

Question 6

Treatment for Zika

Answer 6

None