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By:
Reagan Smith
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Decks in this class (14)
IV Bolus - 1
Pharmacokinetics pk 1,
Optimal drug therapy 2,
Iv bolus 3
35
cards
Drug Distribution - 2
__ concentration gradient __ satu...,
Paracellular transport is for hyd...,
__ concentration gradient 3
36
cards
Constant rate regimen -3
The drug is administered systemic...,
Constant plasma concentration can...,
Iv bolus dose is eliminated ___ w...
15
cards
Oral PK - 4
What is f 1,
Why is it technically wrong to us...,
___ delays and reduces the magnit...
11
cards
Hepatic Drug Metabolism - 5
Blood flows out of the liver thro...,
Bile composition and function 2,
Hepatocyte responsibilities 3
23
cards
F/CL - 6
Absolute vs relative bioavailabil...,
Example if the absolute bioavaila...,
Larger ___ means that the body is...
16
cards
Bioavailability and Clearance - 7
Total clearance is equal to 1,
Extraction ratio e 2,
Q represents 3
7
cards
Multiple Dose PK/dosing regimen
Less frequent dosing ie larger le...,
Less frequent dosing ie larger le...,
T or f higher dose is expected to...
6
cards
Multicompartmental PK
One compartment model 1,
Why do we need a multi compartmen...,
The two compartment model is 3
16
cards
Noncompartmental PK analysis
Mrt of a drug would mean the __ t...,
After multiple doses aucss 0 is e...,
Mrt approaches for its estimation 3
10
cards
Metabolite PK
Metabolites can affect pk of a __...,
What is the metabolite of zidovud...,
Most effects of metabolites are _...
14
cards
Transporters
Example of efflux transporter 1,
Uptake transporters 2 2,
Oatp organic __ trasporting prote...
28
cards
Biologics PK handout
Generally derived from __ material 1,
Examples of biologics 2,
Monoclonal antibodies 3
31
cards
Nonlinear Pharmacokinetics
Drug concentrations are __ to the...,
Examples of saturable processes g...,
__ transport in the gut wall 3
18
cards
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PHRM 835
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