Noncompartmental PK analysis

Question 1

MRT of a drug would mean the ___ time one drug molecule spends in the body from ___ to ___

Answer 1

• average
• dosing to elimination

Question 2

AUC: Superposition principle

After multiple doses, AUCss,0-𝜏 is equal to ___ irrespective of peak shapes

Answer 2

AUCsingle dose, 0-∞

Question 3

one-compartment model

MRT: Approaches for its estimation

Estimation from elimination rate constant, k

Answer 3

Question 4

After IV administration, Drug A and Drug B show MRT values of 1 and 5 hr,
respectively. Which drug is eliminated faster?
* Drug A
* Drug B
* Not enough info is given

Answer 4

Drug A

Question 5

The volume of distribution observed after the drug has distributed into
the tissues is the

Answer 5

Vdss

Question 6

MRT, AUMC, AUC, CL, and Vdss are ___ PK parameters

Answer 6

noncompartmental

Question 7

practice question

Answer 7

True to all

Question 8

noncompartmental vs compartmental

Each approach is useful and ___

Answer 8

limited

Question 9

noncompartmental. characteristics

• Minimal number of ___ (minimizes bias)
• Will work for many type of data (descriptive)
• Can compare across ___
• Limited in information about ___ processes
• No assumptions about ___ into body or segmented
  processes in the body (holistic)
• Poor relating to specific ___ function
• Sometimes, favored approach due to lack of ___

Answer 9

• assumptions
• data sets/drugs
• secondary
• distribution
• organ
• assumptions

Question 10

compartmental characteristics

• Fits data for a ___ case
• Better accounts for ___ processes
• Provides better insight into “fate of ___”
• Driven by data and by ___
• Capability to predict ___ for certain time point

Answer 10

• specific
• biological
• drug
• assumptions
• concentrations