Multicompartmental PK Flashcards
One compartment model
* The body acts like a ___ homogenous compartment and drug rapidly distributes uniformly in it
* The drug is in rapid ___ between the blood and the tissues
* Changes in the plasma concentration of drug will result in ___ changes in tissue drug levels
- single
- equilibrium
- proportional
Why do we need a multi-compartment model?
Blood flow to each tissue varies
The Two Compartment Model is
* ___ - exponential
* ___ - phasic
Bi
Distribution phase: ___ also occurs, but distribution into the ___ compartment governs the slope
- elimination
- tissue
Elimination phase: elimination from the ___ compartment governs the slope
central
two compartment model
- α represents the ___ rate constant
- β represents the ___ rate constant
- distribution
- elimination
A, α, B, and β are all ___ constants
macro
k12, k21, and k10 are all ___ constants
micro
- k12 represents elimination from ___ to ___
- k21 represents elimination from ___ to ___
- k10 represnts elimnation from ___
- central to peripheral
- peripheral to central
- central
distribution half-life = ___
0.693/α
terminal half-life =
0.693/β
This is an example of a ___ compartmental model
one
This is an example of a ___ compartmental model
two
Vdβ represents
the volume of distribution in the β-phase (post-distribution/terminal phase)
Vc < Vdβ
- Vc represents the ___ volume of distribution
- Vp represents ___ volume of distribution
- central
- peripheral
practice question
- true
- true
- false
- true
