Flashcards in 02 PK Test Questions Deck (15):
What is the therapeutic range for Digoxin?
CHF: 0.5-0.9 mgc/L. AF: 0.5-2 mcg/L
What is the bioavailability like for Digoxin?
Tab (0.7), Elixir (0.8), Caps (1)
What is the half-life of Digoxin?
What is protein binding like with Digoxin?
Very little, 90% unbound
What is the therapeutic range for one daily AMG dosing?
Peak: 20-30mg/L, Trough: undetectable
What is the therapeutic range for conventional AMG dosing?
Peak: 5-8, Trough: < 2mg/L
What is the therapeutic range for Vanco?
Target trough: 5-20 (4-5x MIC). Concentration INDEPENDENT bactericidal activity
When is a loading dose usually required?
If the LD is 10% greater than the MD
What should be monitored while on AMG or Vanco?
Obtain BUN/Scr 2-3 times weekly. Obtain CBC weekly
How can AMGs doses be rounded?
To the nearest 20
How can Vanco doses be rounded?
Usually in increments of 250mg for practicality
What is the therapeutic range for Phenytoin?
What is the ABW formula?
IBW + 0.4(TBW-IBW)
What is the therapeutic plasma concentration for Carbamazepine?