02 PK Test Questions Flashcards Preview

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Flashcards in 02 PK Test Questions Deck (15):
1

What is the therapeutic range for Digoxin?

CHF: 0.5-0.9 mgc/L. AF: 0.5-2 mcg/L

2

What is the bioavailability like for Digoxin?

Tab (0.7), Elixir (0.8), Caps (1)

3

What is the half-life of Digoxin?

2 days

4

What is protein binding like with Digoxin?

Very little, 90% unbound

5

What is the therapeutic range for one daily AMG dosing?

Peak: 20-30mg/L, Trough: undetectable

6

What is the therapeutic range for conventional AMG dosing?

Peak: 5-8, Trough: < 2mg/L

7

What is the therapeutic range for Vanco?

Target trough: 5-20 (4-5x MIC). Concentration INDEPENDENT bactericidal activity

8

When is a loading dose usually required?

If the LD is 10% greater than the MD

9

What should be monitored while on AMG or Vanco?

Obtain BUN/Scr 2-3 times weekly. Obtain CBC weekly

10

How can AMGs doses be rounded?

To the nearest 20

11

How can Vanco doses be rounded?

Usually in increments of 250mg for practicality

12

What is the therapeutic range for Phenytoin?

10-20mg/L

13

What is the ABW formula?

IBW + 0.4(TBW-IBW)

14

What is the therapeutic plasma concentration for Carbamazepine?

4-12mg/L

15

What is a quick formula to figure out the loading dose for Digoxin?

(Cp(V))/F