04.21 - CHF Pharm (Ostrom) Flashcards
(85 cards)
Tx for Stage A CHF
Preventive Measures, ACEi’s and ARB’s
___ is a vasodilator that acts directly on vascular SM
Hydralazine
2 “other” Considerations for Diuretic Tx in CHF
ACEi’s and ARB’s also have diuretic effects; Spirinolactone, Eplerenone have benefits beyond diuretic effect
3 BB’s approved for CHF
Metoprolol, Carvedilol, Bisoprolol (Carved Bison Meat)
3 most common AE’s of ACEi’s
First dose hypotension, Na depletion, Dry Cough
3 most common AE’s of Aliskerin
First dose hypotension, Hyperkalemia, Angioedema
3 most common AE’s of ARB’s
First dose hypotension, Hyperkalemia, Hepatic Dysfunction
4 Drugs that interact with Digoxin
Quinidine, Amiodarone, Verapamil, Diuretics
ACEi effect on Bradykinin
Increase levels due to inhibitor of metabolism
ACEi’s end in
pril
Advantage of ACEi’s
Little effect on lipids or sexual function
Advantage of Milrinone over Dobutamine
Milrinone doesn’t desensitize receptors
Aldosterone and AngII combine to stimulate
fibrosis in cardiac tissue
Angiotensin Receptor Antagonists end in
tan
Arterial Vasodilators alone may what change in Frank-Starling Curve
Left and Upward
Arterial Vasodilators work best when combined with
Inotrope and Diuretic
At what stage do you add beta blockers
B (NYHA I)
At what stage do you add Diuretic, Digoxin
C (NYHA II, III)
BB approved for CHF only in Europe
Nebivolol
BB least likely to induce increase TPR cause by reflex vasoconstriction
Carvedilol: alpha1 antagonist
BB that potentiates NO in vasculature; approved for HTN but not CHF
Nevivolol
Benefit of Nesiritide is comparable to
IV nitroglycerin but hypotension may persist longer
Can hemodynamic drugs slow progression of CHF?
No
Diuretics effects on Preload, CO
Reduce Preload, Do NOT increase CO
