091614 epidermis Flashcards Preview

Musculoskeletal, Skin > 091614 epidermis > Flashcards

Flashcards in 091614 epidermis Deck (24):
1

layers of epidermis from superficial to deep

stratum corneum
stratum granulosum
stratum spinosum
stratum basale

2

basal stem cells in the epidermis give rise to keratinocytes how?

divide to form one daughter cell and a transient amplifying cell

transient amplif cell will divide a few more times before it moves up into the stratum spinosum

3

what layer makes up most of the epidermis

spinous layer

4

what does the stratum spinosum do?

makes keratin

5

hemidesmosome

connection btwn basal cell and ECM

has keratin intermediate filaments on intracellular side

6

what is the importance of the keratin intermediate filaments in the epidermis

they allow for formation of a network through all the keratinocytes

7

keratin structure

one type I acidic keratin combines with a type II basic keratin to form a heterodimer

heterodimers combine to form tetramers

tetramers are combined to form protofilaments, which then combine to form intermediate filaments

8

true or false: keratin types vary in different locations in the body

true

9

what kinds of granules are the stratum granulosum

keratohyalin granules (filaggrin, involucrin, loricrin)

lamellar granules or Odland bodies (ceramides, cholesterol, fatty acids, hydrolytic enzymes)

10

corneocytes lack what?

nucleus and organelles

11

how are corneocytes held together

corneodesmosomes

12

which sites have no stratum corneum

oral, genital, ocular mucosa

13

which sites have thin cornified layer

face
genitalia

14

how does stratum corneum shed?

by hydrolytic enzymes that were in the lamellar granules of stratum granulosum

15

bricks and mortar

corneocytes have this structure
the bricks are the cornified enveloped of proteins

the mortar is the surrounding lipid envelope

16

pemphigus vulgaris

acquired
autoimmune bullous (blisters) disease
auto antibodies to desmosomal proteins (desmoglein 1 and 3)

intraepidermal blistering

17

clinical features of pemphigus vulgaris

flaccid, easily ruptured bullae
oral and mucosal lesions
positive NIkolsky's sign (fragile epidermis so by rubbing, can expand the erosion)

18

treatment for pemphigus vulgaris

prednisone
azathioprine
mycophenolate mofetil
rituximab

19

ichthyosis vulgaris

autosomal dominant genetic condition
mutations in profillaggrin gene (defective filaggrin protein)

1 in 250 ppl affected

20

clinical features of icthyosis vulgaris

fish scales especially on shins
dry skin
hyperlinear palms

21

associations of ichthyosis vulgaris

atopic dermatitis
allergic rhinitis
food allergies
asthma

22

UV-A penetrates what layer of the skin
what does it cause?

dermis
causes tanning and wrinkles

23

which types of UV light can cause cancer?

both UVA and UVB

24

MED

minimal erythemia dose, which is the minimum amt of UVB that causes skin redness at 24 hours