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Question 1

What are examples of single chain TKRs?

Answer 1

Single Chain TKRs (Inactive State):

EGF (Epidermal Growth Factor)
FGFR (Fibroblast Growth Factor Receptor)
NGF (Nerve Growth Factor Receptor)
PDGR (Platelet-Derived Growth Factor Receptor)
VEGF (Vascular Endothelial Growth Factor Receptor)

Anything that has growth factor except IGF-1

Question 2

What are examples of two chain TKRs?

Answer 2

Two Chain TKRs (Inactive State):

Insulin Receptor
IGF-1 Receptor (Insulin-like Growth Factor 1 Receptor)

Question 3

What is the structure of the extracellular domain of TKR’s?

Answer 3

Cysteine-Rich Domain: Helps stabilize the structure of the receptor.

Fibronectin-like Domain: Provides additional structural support and plays a role in cell adhesion.

Immunoglobulin-like Domain: Similar to antibodies, it plays a key role in the receptor’s ability to bind ligands with high specificity.

Question 4

What is the meaning of signaling transduction?

Answer 4

Signaling cascade

Question 5

What are Src’s?

Answer 5

Non receptor tyrosine kinases

Question 6

What is the structure of Srcs?

Answer 6

C-terminal

SH domains

T-terminal