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🦠MICROBIOLOGY🦠 > 1-Respiratory Viruses (influenza, rabies, corona) > Flashcards

1-Respiratory Viruses (influenza, rabies, corona) Flashcards

1
Q

TAXONOMY OF FLUE/influenza

A

Orthomyxoviridae
Influenza

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2
Q

TAXONOMY OF RABIES

A

Rabdoviridae vesiculovirus /Lyssavirus

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3
Q

TAXONOMY OF CORONA VIRUS

A

coronaviridae coronavirus

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4
Q

morphology of flue virus

A
  • spherical shape
    -complex virus (enveloped/supra-capsid)
  • 8 segments of single stranded RNA (-ve).

*2 surface glycoproteins.
-hemagglutinin (H) =adhesion
-neuraminidase (N) = penetration

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5
Q

morphology of coronavirus

A
  • spherical shape
    -complex virus (enveloped/supra-capsid)
  • single stranded RNA (+ve) (double strain); (unsegmented)
  • surface antigens
    -spike protein (S) = adhesion.
    -(N) protein = penetration
    -M (matrix) protein (inside supra-capsid) = replication
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6
Q

morphology of rabies

A
  • bullet-shape
    -complex virus (enveloped/supra-capsid)
  • single stranded Helical RNA (-ve)
  • surface antigens
    -G protein = Binding.
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7
Q

cultivation of corona virus

A

no. thank you

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8
Q

cultivation of flu

A

-chicken embryos.
-cell lines (usually that from gate of infection)

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9
Q

cultivation of rabies

A

-warm-blooded animals (mice)
-chicken embryo

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10
Q

antigenic properties (+ virulence factors) of flu

A
  • H Antigen*
  • N Antigen*
  • M Antigen

*(factors of virulence)
- H (for adhesion)
- N (for penetration)

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11
Q

antigenic properties (+ virulence factors) of rabies

A

*(factors of virulence)
- G Antigen (=BINDING)
- M (matrix) protein (=replication)
- NS ( nonstructural) Protein
- RNA Polymerase (viral genome replication and transcription.)

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12
Q

antigenic properties (+ virulence factors) of coronavirus

A

*-S spikes (for adhesion)
*-N antigen= penetration
*-M (matrix) protein = for replication

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13
Q

pathogenicity of flue

A
  • source =sick person
  • trans. method =
    1)air borne & air drop
    2)contact mechanism
  • gate = mucus of upper resp. tract

pathogenesis:
(cytopathogenic)
- H antigen attaches to CM of mucosal cells in upper resp. tract. N antigen. helps penetrate it, viral RNA is replicated.
- followed by cellular destruction due to its cytopathic action,
-Regeneration of epithelium is slow, leaving the resp. system susceptible to bacterial superinfections.

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14
Q

clinical manifestations of flue

A
  • high temp
  • sore throat
  • muscle ache
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15
Q

pathogenicity of coronavirus

A
  • source = sick person
  • trans. method = 1)air borne 2) alimentary 3)contact
  • gate = mucus of upper resp. tract
  • pathogenesis: (cytopathogenic)
  • s antigen attaches, n antigen penetrates, m protein replicates viral genome
    -(cytopathic) host cell rupture to release newly replicated virus
  • they infect closer cells (goes to intestines, CNS,PNS, brain, heart)
  • neurons proliferate slowly , so eventually NS system destroyed.
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16
Q

clinical manifestations of coronavirus

A
  • loss of smell and taste senses
  • post-covid complications; (heart & neurological issues) like= memory loss, tachycardia / high BP
  • respiratory complications; (like pneumonia & lack of O2)
17
Q

pathogenicity of rabies

A
  • source = wild animals (1- dogs, wolves, fox) - 2)rodents 3)cats
  • trans. method = CONTACT of contaminated saliva from animal BITE (with the open wound)
  • gate = muscles, nerve endings at wound area.
  • pathogenesis: (cytopathogenic)
  • virus enters tissues from saliva of the bite
  • replicates in nearby muscle and nerve tissues
  • (cytopathic) kills host cell during replication and moving onto the next and so
  • affects nerves, CNS, PNS
18
Q

clinical manifestations of rabies

A
  • paralysis of the limbs (arms, legs)
  • tingling sensations in fingertips
  • hallucinations
  • pain in swallowing , thus hydrophobia
  • photophobia
19
Q

treatment of coronavirus

A

anti-covid preparation

20
Q

prophylaxis of coronavirus

A

(recombinant vaccine)

21
Q

lab diagnosis of coronavirus

A

-ELISA
-PCR

22
Q

lab diagnosis of rabies

A

-ELISA, PCR
- antigen detection by immunofluorescence (IF).

23
Q

lab diagnosis of flu

A
  • PCR
  • ELISA
  • CFT
24
Q

treatment of flu

A
  • anti-viral drugs
  • Immunomodulators
25
Q

prophylaxis of flu

A

(subunit) vaccine
or (live) vaccine

26
Q

treatment of rabies

A
  • only local wound treatment
  • immediate post-exposure prophylaxis; with anti-rabies vaccine & immmuno-globulin injections (-passive immunity)
27
Q

prophylaxis of rabies

A

preexposure vaccine

🦠MICROBIOLOGY🦠 (8 decks)

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