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Flashcards in 10 - Bone Dz Deck (11):
1

how long does bone remodeling take?

4-8 mo

2

regulatory fn of: RANKL, OPG, TGFbeta1

RANKL activates osteoclasts
OPG (osteoprotegerin) competitively binds RANKL to inhibit activation of osteoclasts
TGFbeta1 inhibits osteoclasts and promotes osteoblasts

3

3 common fracture sites in osteoporosis

spine
hip
wrist

4

med class that makes osteoporosis worse

corticosteroids

5

what is an abnl bone density?

more than one SD below young adult female reference mean (osteopenia), osteoporosis when >2.5 SD below

6

tx for osteoporosis (7)

Ca + vit D
bisphosphonates *1st line
teriparatide (can't be used w/ bisphosphonates)
SERMs (raloxifene)
HRT
calcitonin
denosumab

7

bisphosphonates mech

block GTPase from binding to osteoclast cell membrane > cant make ruffled border > impaired resorption

8

markers to look for for paget's dz

urinary and serum N-telopeptide (signals inc bone resorption)

9

tx of paget's

bisphosphonates

10

underlying problem of osteopetrosis

dec osteoclast activity

11

marker for osteopetrosis

osteoclast derived TRAP (tartrate resistant acid phosphatase) elevated